| URN | urn:agi-llid:5601 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1015 |
| Name | Mapk9 |
| Description | mitogen-activated protein kinase 9 |
| Notes | kinase activated by cellular stress and tumour necrosis factor (TNF)-alpha [RGD] |
| Ariadne Ontology | JNK |
|---|---|
| Secreted proteins |
| GO Molecular Function | transcription factor binding |
|---|---|
| mitogen-activated protein kinase kinase kinase binding | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| JUN kinase activity | |
| cysteine-type endopeptidase activator activity involved in apoptotic process |
| GO Cellular Component | nucleoplasm |
|---|---|
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosolic part | |
| cytosol | |
| nucleus |
| GO Biological Process | positive regulation of apoptotic signaling pathway |
|---|---|
| regulation of JNK cascade | |
| signal transduction by phosphorylation | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of prostaglandin biosynthetic process | |
| positive regulation of protein phosphorylation | |
| regulation of protein ubiquitination | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of cell morphogenesis involved in differentiation | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein phosphorylation | |
| JUN phosphorylation | |
| phosphorylation | |
| cellular response to growth factor stimulus | |
| cellular response to interleukin-1 | |
| cellular response to tumor necrosis factor | |
| cellular response to lipopolysaccharide | |
| cellular response to UV | |
| release of cytochrome c from mitochondria | |
| neuron projection development | |
| innate immune response | |
| response to stress | |
| response to organic substance | |
| response to drug | |
| response to toxin | |
| response to cadmium ion | |
| response to amine stimulus | |
| response to mechanical stimulus | |
| positive regulation of chemokine production | |
| positive regulation of gene expression | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| positive regulation of prostaglandin secretion | |
| central nervous system development | |
| protein targeting to mitochondrion |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EctodysplasinR -> AP-1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| FrizzledR -> JUN/PAX2 signaling | |
| TGFBR -> AP-1 signaling | |
| TLR -> AP-1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| GNRHR -> ELK-SRF signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| EphrinB -> JUN signaling | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| FASLG Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| GNRH2 Expression Targets | |
| AREG/AP-1 Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| HBEGF/TP53 Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/TP53 Expression Target | |
| TGFA/TP53 Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| GNRH1 Expression Targets | |
| S1P Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| WNT5A Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| BTC/AP-1/ATF/CREB Expression Targets | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | JNK |
|---|---|
| positive regulation of apoptotic signaling pathway | |
| regulation of JNK cascade | |
| signal transduction by phosphorylation | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of prostaglandin biosynthetic process | |
| positive regulation of protein phosphorylation | |
| regulation of protein ubiquitination | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of cell morphogenesis involved in differentiation | |
| positive regulation of apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein phosphorylation | |
| JUN phosphorylation | |
| phosphorylation | |
| cellular response to growth factor stimulus | |
| cellular response to interleukin-1 | |
| cellular response to tumor necrosis factor | |
| cellular response to lipopolysaccharide | |
| cellular response to UV | |
| release of cytochrome c from mitochondria | |
| neuron projection development | |
| innate immune response | |
| response to stress | |
| response to organic substance | |
| response to drug | |
| response to toxin | |
| response to cadmium ion | |
| response to amine stimulus | |
| response to mechanical stimulus | |
| positive regulation of chemokine production | |
| positive regulation of gene expression | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| positive regulation of prostaglandin secretion | |
| central nervous system development | |
| protein targeting to mitochondrion | |
| transcription factor binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| JUN kinase activity | |
| cysteine-type endopeptidase activator activity involved in apoptotic process | |
| nucleoplasm | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosolic part | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| Source | Curated |
|---|---|
| GO component | |
| RGD modified | |
| ResNet |
| MedScan ID | 5601 |
|---|
| Hugo ID | 6886 |
|---|
| Human chromosome position | 5q35 |
|---|
| LocusLink ID | 5601 |
|---|---|
| 26420 | |
| 50658 | |
| 19100 | |
| 103866 | |
| 50657 | |
| 534125 | |
| 562552 |
| Alias | JNK2 |
|---|---|
| SAPK | |
| p54a | |
| JNK2A | |
| JNK2B | |
| PRKM9 | |
| JNK-55 | |
| SAPK1a | |
| JNK2BETA | |
| p54aSAPK | |
| JNK2ALPHA | |
| mitogen-activated protein kinase 9 | |
| MAPK 9 | |
| Jun kinase | |
| MAP kinase 9 | |
| c-Jun kinase 2 | |
| c-Jun N-terminal kinase 2 | |
| stress-activated protein kinase 1a | |
| stress-activated protein kinase JNK2 | |
| AI851083 | |
| RP23-10G21.6 | |
| JNK/SAPK alpha | |
| mitogen activated protein kinase 9 | |
| protein kinase, mitogen-activated 9 | |
| p54-alpha | |
| SAPK-alpha | |
| stress activated protein kinase alpha II | |
| OTTMUSP00000005725 | |
| OTTHUMP00000161543 | |
| OTTHUMP00000161542 | |
| MK09_HUMAN | |
| mitogen-activated protein kinase 9 isoform JNK2 alpha2 | |
| MK09 | |
| OTTMUSP00000005727 | |
| protein kinase mitogen-activated 9 | |
| OTTMUSP00000005726 | |
| MAPK9 | |
| OTTMUSP00000005728 | |
| c-Jun kinase II | |
| c-Jun N-terminal kinase II | |
| JNK/SAPK | |
| Jun kinase 2 | |
| Jun kinase II | |
| kinase JNK2 | |
| Stress-activated protein kinase JNK2 | |
| protein kinase mitogen-activated 9 (MAP kinase) | |
| IL23R | |
| interleukin-23 receptor | |
| MAPK9. | |
| protein kinase JNK2 | |
| LOC562552 | |
| chromosome | |
| scaffold | |
| similar to MGC116516 protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 602896 |
|---|---|
| OMIM:602896 |
| Unigene ID | Hs.484371 |
|---|---|
| Mm.68933 | |
| Rn.9910 | |
| Rn.177202 | |
| Hs.654461 | |
| Hs.348446 | |
| Bt.52287 | |
| Dr.34373 |
| KEGG ID | hsa:5601 |
|---|---|
| mmu:26420 | |
| rno:50658 |
| Swiss-Prot Accession | P45984 |
|---|---|
| Q5NCK7 | |
| Q8C094 | |
| Q9WTU6 | |
| Q5NCK8 | |
| D4A5V8 | |
| Q6P727 | |
| P49186 | |
| A8K0S3 | |
| B5BU66 | |
| B5M0B4 | |
| D3DWQ8 | |
| D3DWQ9 | |
| Q15708 | |
| Q15710 | |
| Q15711 | |
| Q8N5C5 | |
| Q5NCK9 | |
| Q5NCL5 | |
| Q8C097 | |
| Q8VDD2 | |
| Q9WTU4 | |
| Q9WTU5 | |
| Q3V398 |
| EC Number | 2.7.11.24 |
|---|---|
| 2.7.1.- | |
| 2.7.1.37 |
| GO ID | 0005524 |
|---|---|
| 0004705 | |
| 0008134 | |
| 0007254 | |
| 0007258 | |
| 0002755 | |
| 0002756 | |
| 0035666 | |
| 0008063 | |
| 0045087 | |
| 0010628 | |
| 0010744 | |
| 0051090 | |
| 0046686 | |
| 0006950 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0005829 | |
| 0005739 | |
| 0005654 | |
| 0004707 | |
| 0008656 | |
| 0016301 | |
| 0031435 | |
| 0000166 | |
| 0004672 | |
| 0004674 | |
| 0016740 | |
| 0016772 | |
| 0006919 | |
| 0034644 | |
| 0031175 | |
| 0016310 | |
| 0043065 | |
| 2001235 | |
| 0010770 | |
| 0032722 | |
| 0043280 | |
| 0045429 | |
| 0051770 | |
| 0031394 | |
| 0032308 | |
| 0001934 | |
| 0045893 | |
| 0006468 | |
| 0046328 | |
| 0031396 | |
| 0001836 | |
| 0042493 | |
| 0023014 | |
| 0005737 | |
| 0044445 | |
| 0005622 | |
| 0005634 | |
| 0071363 | |
| 0071347 | |
| 0071222 | |
| 0071356 | |
| 0007417 | |
| 0006626 | |
| 0014075 | |
| 0009612 | |
| 0010033 | |
| 0009636 | |
| 0031558 | |
| 0051773 | |
| 0045941 | |
| 0051789 | |
| 0034097 | |
| 0032496 | |
| 0005515 | |
| 0004713 | |
| 0016020 | |
| 0004682 | |
| 0004691 |
| PIR ID | S43968 |
|---|---|
| A55480 | |
| S71102 |
| Swiss-Prot ID | MK09_RAT |
|---|---|
| MK09_HUMAN | |
| MK09_MOUSE | |
| D3DWQ8_HUMAN | |
| Q8C094_MOUSE | |
| D3DWQ9_HUMAN | |
| Q5NCK8_MOUSE | |
| B5M0B4_HUMAN | |
| Q5NCK7_MOUSE | |
| A8K0S3_HUMAN | |
| B5BU66_HUMAN | |
| Q5NCK9_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Plasma membrane |
| IPI ID | IPI00191806 |
|---|---|
| IPI00231634 | |
| IPI00024673 | |
| IPI00220382 | |
| IPI00220383 | |
| IPI00303550 | |
| IPI00123875 | |
| IPI00223339 | |
| IPI00223340 | |
| IPI00223342 | |
| IPI00913982 | |
| IPI00653963 | |
| IPI00777753 |
| Mouse chromosome position | 11 |
|---|---|
| 11 B1.2 |
| Rat chromosome position | 10q22 |
|---|
| Homologene ID | 55685 |
|---|
| MGI ID | 1346862 |
|---|---|
| 2144306 | |
| 1202396 |
| RGD ID | 628847 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 5q35 |
|---|
| Microarray ID | 101362_at |
|---|---|
| 203218_at | |
| 1421877_at |
| FunctionalClass | ATP binding |
|---|---|
| JUN kinase | |
| MAP kinase | |
| nucleotide binding | |
| protein binding | |
| protein serine/threonine kinase | |
| transferase | |
| kinase | |
| protein kinase | |
| protein-tyrosine kinase | |
| cAMP-dependent protein kinase | |
| protein kinase CK2 |
| Mus musculus Chromosome position | 11 B1.3 |
|---|---|
| 11 B1.2 | |
| 11 |
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Colorectal cancer | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Focal adhesion | |
| GnRH signaling pathway | |
| Insulin signaling pathway | |
| MAPK signaling pathway | |
| Pancreatic cancer | |
| Toll-like receptor signaling pathway | |
| Type II diabetes mellitus | |
| Wnt signaling pathway |
| Rattus norvegicus Chromosome position | 10q22 |
|---|
| Bos taurus Chromosome position | 7 |
|---|