| URN | urn:agi-llid:6416 |
|---|---|
| Total Entities | 0 |
| Connectivity | 611 |
| Name | Map2k4 |
| Description | mitogen activated protein kinase kinase 4 |
| Notes | This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. |
| Ariadne Ontology | MKK4-7 |
|---|
| GO Molecular Function | mitogen-activated protein kinase kinase kinase binding |
|---|---|
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase activity | |
| JUN kinase kinase activity |
| GO Cellular Component | perikaryon |
|---|---|
| cytoplasm | |
| cytosol | |
| dendrite cytoplasm | |
| nucleus | |
| axon part |
| GO Biological Process | activation of JUN kinase activity |
|---|---|
| signal transduction | |
| MAPK cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| positive regulation of DNA replication | |
| positive regulation of protein phosphorylation | |
| positive regulation of apoptotic process | |
| positive regulation of neuron apoptotic process | |
| protein phosphorylation | |
| phosphorylation | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| innate immune response | |
| response to stress |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EctodysplasinR -> AP-1 signaling | |
| TNFRSF6 -> HSF1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| NGFR -> MEF signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| FrizzledR -> JUN/PAX2 signaling | |
| Notch -> TCF3 signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR -> AP-1 signaling | |
| IL1R -> STAT3 signaling | |
| TLR -> AP-1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| GDNF -> HSF1 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| GNRHR -> ELK-SRF signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| EphrinB -> JUN signaling | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| FASLG Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| Fibronectin Expression Targets | |
| Thrombopoietin/SPI1 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| GNRH2 Expression Targets | |
| AREG/AP-1 Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| HBEGF/TP53 Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/TP53 Expression Target | |
| TGFA/TP53 Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| VEGFC/ATF Expression Target | |
| GDNF/HSF1 Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| AREG/CREB/CREBBP Expression Targets | |
| EREG/CREB Expression Target | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFC/CREB Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| ANGPT1/CREB/CREBBP Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| GNRH1 Expression Targets | |
| S1P Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| IL16/ATF/CREB/CREBBP Expression Target | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| CD80/ATF/CREB/CREBBP Expression Targets | |
| CD86/ATF/CREB/CREBBP Expression Targets | |
| CD72/CREB/CREBBP Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| IL1A Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| NOTCH Expression Targets | |
| WNT5A Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| BTC/AP-1/ATF/CREB Expression Targets | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | MKK4-7 |
|---|---|
| activation of JUN kinase activity | |
| signal transduction | |
| MAPK cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| positive regulation of DNA replication | |
| positive regulation of protein phosphorylation | |
| positive regulation of apoptotic process | |
| positive regulation of neuron apoptotic process | |
| protein phosphorylation | |
| phosphorylation | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| innate immune response | |
| response to stress | |
| mitogen-activated protein kinase kinase kinase binding | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase activity | |
| JUN kinase kinase activity | |
| perikaryon | |
| cytoplasm | |
| cytosol | |
| dendrite cytoplasm | |
| nucleus | |
| axon part |
| Source | Curated |
|---|---|
| RGD modified | |
| ResNet |
| MedScan ID | 6416 |
|---|
| Hugo ID | 6844 |
|---|
| Human chromosome position | 17p12 |
|---|---|
| 17p11.2 |
| LocusLink ID | 6416 |
|---|---|
| 26398 | |
| 287398 | |
| 20367 | |
| 526469 | |
| 403052 |
| Alias | JNKK |
|---|---|
| MEK4 | |
| MKK4 | |
| SEK1 | |
| JNKK1 | |
| SERK1 | |
| MAPKK4 | |
| PRKMK4 | |
| SAPKK1 | |
| SAPKK-1 | |
| dual specificity mitogen-activated protein kinase kinase 4 | |
| MEK 4 | |
| MAPKK 4 | |
| SAPK kinase 1 | |
| MAPK/ERK kinase 4 | |
| SAPK/ERK kinase 1 | |
| MAP kinase kinase 4 | |
| JNK-activated kinase 1 | |
| JNK activating kinase 1 | |
| JNK-activating kinase 1 | |
| c-Jun N-terminal kinase kinase 1 | |
| stress-activated protein kinase kinase 1 | |
| RP23-340L19.1 | |
| JNKK 1 | |
| JNK kinase 1 | |
| SAPK/Erk/kinase 1 | |
| mitogen activated protein kinase kinase 4, variant 1 | |
| SKK1 | |
| MAPK/ERK kinase IV | |
| OTTMUSP00000006102 | |
| mitogen-activated protein kinase kinase IV | |
| mitogen activated protein kinase kinase 4 | |
| SAPK kinase I | |
| SEK I | |
| SERK I | |
| SAPK/ERK kinase I | |
| JNK kinase | |
| c-Jun N- terminal kinase kinase I | |
| Dual specificity mitogen-activated protein kinase kinase IV | |
| JNK activating kinase I | |
| JNK-activated kinase I | |
| MAPK kinase 4 | |
| JNKK I | |
| MAPK kinase IV | |
| c-Jun N- terminal kinase kinase 1 | |
| MAP kinase kinase IV | |
| Map2k4 | |
| mitogen-activated protein kinase kinase 4 | |
| PRKMK4s | |
| MAPKK4s | |
| HEK8 | |
| dual specificity mitogen-activated protein kinase kinase 4 | |
| chromosome | |
| scaffold | |
| zMKK4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 601335 |
|---|---|
| OMIM:601335 |
| Unigene ID | Hs.514681 |
|---|---|
| Mm.412922 | |
| Rn.198875 | |
| Rn.19653 | |
| Hs.134106 | |
| Mm.27491 | |
| Bt.23717 | |
| Dr.82506 |
| KEGG ID | hsa:6416 |
|---|---|
| mmu:26398 | |
| rno:287398 |
| Swiss-Prot Accession | P45985 |
|---|---|
| P47809 | |
| Q543X6 | |
| Q4KSH6 | |
| B2R7N7 | |
| B3KYB2 | |
| D3DTS5 | |
| Q5U0B8 | |
| Q6FHX4 | |
| Q6P9H2 | |
| Q6PIE6 | |
| Q8K2U0 |
| EC Number | 2.7.12.2 |
|---|---|
| 2.7.1.- |
| GO ID | 0005524 |
|---|---|
| 0004672 | |
| 0004674 | |
| 0004713 | |
| 0007254 | |
| 0002755 | |
| 0002756 | |
| 0035666 | |
| 0008063 | |
| 0006915 | |
| 0071260 | |
| 0045087 | |
| 0007165 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0005829 | |
| 0005634 | |
| 0008545 | |
| 0004708 | |
| 0016301 | |
| 0031435 | |
| 0000166 | |
| 0016740 | |
| 0016772 | |
| 0000165 | |
| 0007257 | |
| 0016310 | |
| 0045740 | |
| 0043065 | |
| 0043525 | |
| 0001934 | |
| 0006468 | |
| 0006950 | |
| 0033267 | |
| 0005737 | |
| 0032839 | |
| 0043204 | |
| 0005515 |
| PIR ID | I38901 |
|---|---|
| S52423 |
| Swiss-Prot ID | MP2K4_HUMAN |
|---|---|
| MP2K4_MOUSE | |
| D3DTS5_HUMAN | |
| Q543X6_MOUSE | |
| Q4KSH6_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00024674 |
|---|---|
| IPI00942214 | |
| IPI00112335 | |
| IPI00369884 | |
| IPI00794157 | |
| IPI00875050 | |
| IPI00649311 |
| Mouse chromosome position | 11 33.0 cM |
|---|
| Rat chromosome position | 10q24 |
|---|
| Homologene ID | 48159 |
|---|
| MGI ID | 1346869 |
|---|---|
| 107199 |
| RGD ID | 1307040 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 17p11.2 |
|---|
| Microarray ID | 99960_at |
|---|---|
| 1426233_at |
| FunctionalClass | ATP binding |
|---|---|
| nucleotide binding | |
| protein binding | |
| protein serine/threonine kinase | |
| protein-tyrosine kinase | |
| transferase | |
| kinase | |
| protein kinase |
| Mus musculus Chromosome position | 11 33.0 cM |
|---|
| KEGG pathway | Fc epsilon RI signaling pathway |
|---|---|
| GnRH signaling pathway | |
| MAPK signaling pathway | |
| Toll-like receptor signaling pathway | |
| ErbB signaling pathway |
| Rattus norvegicus Chromosome position | 10q24 |
|---|
| Bos taurus Chromosome position | 19 |
|---|