| URN | urn:agi-llid:4296 |
|---|---|
| Total Entities | 0 |
| Connectivity | 278 |
| Name | Map3k11 |
| Description | mitogen-activated protein kinase kinase kinase 11 |
| Notes | The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. |
| Ariadne Ontology | MAP3K |
|---|
| GO Molecular Function | mitogen-activated protein kinase kinase binding |
|---|---|
| mitogen-activated protein kinase kinase kinase binding | |
| Rac GTPase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase kinase activity | |
| JUN kinase kinase kinase activity |
| GO Cellular Component | microtubule |
|---|---|
| centrosome | |
| cytoplasm | |
| cytoskeleton |
| GO Biological Process | cell proliferation |
|---|---|
| microtubule-based process | |
| cell death | |
| G1 phase of mitotic cell cycle | |
| positive regulation of JNK cascade | |
| activation of JNKK activity | |
| regulation of JNK cascade | |
| positive regulation of JUN kinase activity | |
| activation of JUN kinase activity | |
| activation of MAPK activity | |
| JNK cascade | |
| positive regulation of apoptotic process | |
| positive regulation of neuron apoptotic process | |
| protein phosphorylation | |
| protein autophosphorylation | |
| phosphorylation |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| FrizzledR -> JUN/PAX2 signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| Fibronectin Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| VEGFC/ATF Expression Target | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| AREG/CREB/CREBBP Expression Targets | |
| EREG/CREB Expression Target | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFC/CREB Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| ANGPT1/CREB/CREBBP Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| IL16/ATF/CREB/CREBBP Expression Target | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| CD80/ATF/CREB/CREBBP Expression Targets | |
| CD86/ATF/CREB/CREBBP Expression Targets | |
| CD72/CREB/CREBBP Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| WNT5A Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | MAP3K |
|---|---|
| cell proliferation | |
| microtubule-based process | |
| cell death | |
| G1 phase of mitotic cell cycle | |
| positive regulation of JNK cascade | |
| activation of JNKK activity | |
| regulation of JNK cascade | |
| positive regulation of JUN kinase activity | |
| activation of JUN kinase activity | |
| activation of MAPK activity | |
| JNK cascade | |
| positive regulation of apoptotic process | |
| positive regulation of neuron apoptotic process | |
| protein phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| mitogen-activated protein kinase kinase binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| Rac GTPase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein tyrosine kinase activity | |
| MAP kinase kinase kinase activity | |
| JUN kinase kinase kinase activity | |
| microtubule | |
| centrosome | |
| cytoplasm | |
| cytoskeleton |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| MedScan ID | 4296 |
|---|
| Hugo ID | 6850 |
|---|
| Human chromosome position | 11q13.1-q13.3 |
|---|
| LocusLink ID | 4296 |
|---|---|
| 26403 | |
| 309168 | |
| 17352 | |
| 76541 | |
| 514210 |
| Alias | MLK3 |
|---|---|
| PTK1 | |
| SPRK | |
| MLK-3 | |
| MEKK11 | |
| mitogen-activated protein kinase kinase kinase 11 | |
| mixed lineage kinase 3 | |
| protein-tyrosine kinase PTK1 | |
| SH3 domain-containing proline-rich kinase | |
| src-homology 3 domain-containing proline-rich kinase | |
| 2610017K16Rik | |
| mitogen activated protein kinase kinase kinase 11 | |
| RHOE | |
| MLK III | |
| PTK I | |
| protein-tyrosine kinase PTK I | |
| MLK IIIs | |
| MAPKKK 11 | |
| mixed lineage kinase III | |
| Map3k11 | |
| 2610017K16 | |
| MGC17114 | |
| Mitogen-associated protein kinase kinase kinase 11 | |
| RIKEN cDNA 2610017K16 gene | |
| SPK1 | |
| Similar to mitogen-activated protein kinase kinase kinase 11 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus |
| OMIM ID | 600050 |
|---|---|
| OMIM:600050 |
| Unigene ID | Hs.502872 |
|---|---|
| Mm.185026 | |
| Rn.28235 | |
| Hs.432787 | |
| Rn.145018 | |
| Bt.27525 |
| KEGG ID | hsa:4296 |
|---|---|
| mmu:26403 | |
| rno:309168 |
| Swiss-Prot Accession | Q16584 |
|---|---|
| Q80XI6 | |
| Q66HA1 | |
| Q80YF1 | |
| Q8K0M8 | |
| Q9JJ15 | |
| Q53H00 | |
| Q59F06 | |
| Q6P2G4 |
| EC Number | 2.7.11.25 |
|---|---|
| 2.7.10.1 | |
| 2.7.1.112 |
| GO ID | 0005524 |
|---|---|
| 0004706 | |
| 0048365 | |
| 0031434 | |
| 0031435 | |
| 0042803 | |
| 0004672 | |
| 0004674 | |
| 0004713 | |
| 0000080 | |
| 0007254 | |
| 0007257 | |
| 0000187 | |
| 0008219 | |
| 0008283 | |
| 0007017 | |
| 0046330 | |
| 0043507 | |
| 0043525 | |
| 0046777 | |
| 0006468 | |
| 0005813 | |
| 0005874 | |
| 0004709 | |
| 0016301 | |
| 0000166 | |
| 0016740 | |
| 0016772 | |
| 0007256 | |
| 0016310 | |
| 0043065 | |
| 0046328 | |
| 0005737 | |
| 0005856 | |
| 0051259 | |
| 0005625 | |
| 0005515 |
| PIR ID | A53800 |
|---|
| Swiss-Prot ID | M3K11_RAT |
|---|---|
| M3K11_MOUSE | |
| M3K11_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| cytoskeleton | |
| centrosome | |
| Nucleus |
| IPI ID | IPI00471828 |
|---|---|
| IPI00330731 | |
| IPI00000977 | |
| IPI00765044 |
| Mouse chromosome position | 19 0.5 cM |
|---|
| Rat chromosome position | 1q43 |
|---|
| Homologene ID | 37618 |
|---|
| MGI ID | 1346880 |
|---|---|
| 1095739 | |
| 1923791 |
| RGD ID | 1359261 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 11q13.1-q13.3 |
|---|
| Microarray ID | 161658_at |
|---|
| FunctionalClass | ATP binding |
|---|---|
| JUN kinase kinase kinase | |
| nucleotide binding | |
| protein binding | |
| protein homodimerization | |
| protein serine/threonine kinase | |
| protein-tyrosine kinase | |
| transferase | |
| kinase | |
| protein kinase |
| Mus musculus Chromosome position | 19 0.5 cM |
|---|
| Rattus norvegicus Chromosome position | 1q43 |
|---|
| Bos taurus Chromosome position | 29 |
|---|