| URN | urn:agi-llid:5599 |
|---|---|
| Total Entities | 0 |
| Connectivity | 4622 |
| Name | Mapk8 |
| Description | mitogen-activated protein kinase 8 |
| Notes | a stress-activated protein kinase [RGD] |
| Ariadne Ontology | JNK |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | histone deacetylase binding |
|---|---|
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| JUN kinase activity | |
| histone deacetylase regulator activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| perikaryon | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| dendrite cytoplasm | |
| nucleus | |
| axon part | |
| vesicle |
| GO Biological Process | positive regulation of microtubule polymerization |
|---|---|
| positive regulation of apoptotic signaling pathway | |
| signal transduction | |
| apoptotic signaling pathway | |
| signal transduction by phosphorylation | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of DNA replication | |
| regulation of histone deacetylation | |
| regulation of transcription, DNA-dependent | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of cell migration | |
| positive regulation of apoptotic process | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| JUN phosphorylation | |
| phosphorylation | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| neuron projection development | |
| innate immune response | |
| response to stress | |
| response to hydrogen peroxide | |
| response to cadmium ion | |
| response to steroid hormone stimulus | |
| response to heat | |
| response to osmotic stress | |
| inflammatory response | |
| response to UV | |
| positive regulation of determination of dorsal identity | |
| positive regulation of gene expression | |
| regulation of gene expression | |
| positive regulation of deacetylase activity | |
| regulation of protein localization | |
| determination of dorsal identity | |
| ossification | |
| negative regulation of protein binding |
| Pathway | Apoptosis |
|---|---|
| FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling | |
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EctodysplasinR -> AP-1 signaling | |
| TNFRSF6 -> HSF1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| FrizzledR -> JUN/PAX2 signaling | |
| Notch -> TCF3 signaling | |
| TGFBR -> AP-1 signaling | |
| TLR -> AP-1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| GDNF -> HSF1 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| GNRHR -> ELK-SRF signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| EphrinB -> JUN signaling | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| FASLG Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| Thrombopoietin/SPI1 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| GNRH2 Expression Targets | |
| AREG/AP-1 Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| HBEGF/TP53 Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/TP53 Expression Target | |
| TGFA/TP53 Expression Targets | |
| GDNF/HSF1 Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| GNRH1 Expression Targets | |
| S1P Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| NOTCH Expression Targets | |
| WNT5A Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| BTC/AP-1/ATF/CREB Expression Targets | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | JNK |
|---|---|
| positive regulation of microtubule polymerization | |
| positive regulation of apoptotic signaling pathway | |
| signal transduction | |
| apoptotic signaling pathway | |
| signal transduction by phosphorylation | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of DNA replication | |
| regulation of histone deacetylation | |
| regulation of transcription, DNA-dependent | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of cell migration | |
| positive regulation of apoptotic process | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| JUN phosphorylation | |
| phosphorylation | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| neuron projection development | |
| innate immune response | |
| response to stress | |
| response to hydrogen peroxide | |
| response to cadmium ion | |
| response to steroid hormone stimulus | |
| response to heat | |
| response to osmotic stress | |
| inflammatory response | |
| response to UV | |
| positive regulation of determination of dorsal identity | |
| positive regulation of gene expression | |
| regulation of gene expression | |
| positive regulation of deacetylase activity | |
| regulation of protein localization | |
| determination of dorsal identity | |
| ossification | |
| negative regulation of protein binding | |
| histone deacetylase binding | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| JUN kinase activity | |
| histone deacetylase regulator activity | |
| nucleoplasm | |
| perikaryon | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| dendrite cytoplasm | |
| nucleus | |
| axon part | |
| vesicle | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| MedScan ID | 5599 |
|---|
| Hugo ID | 6881 |
|---|
| Human chromosome position | 10q11.22 |
|---|
| LocusLink ID | 5599 |
|---|---|
| 26419 | |
| 116554 | |
| 19098 | |
| 105560 | |
| 326419 | |
| 50656 | |
| 71973 | |
| 102478 | |
| 445436 | |
| 539941 | |
| 65236 |
| Alias | JNK |
|---|---|
| JNK1 | |
| PRKM8 | |
| SAPK1 | |
| JNK-46 | |
| JNK1A2 | |
| SAPK1c | |
| JNK21B1/2 | |
| mitogen-activated protein kinase 8 | |
| MAP kinase 8 | |
| JUN N-terminal kinase | |
| c-Jun N-terminal kinase 1 | |
| stress-activated protein kinase 1 | |
| stress-activated protein kinase 1c | |
| mitogen-activated protein kinase 8 isoform JNK1 beta2 | |
| mitogen-activated protein kinase 8 isoform JNK1 alpha1 | |
| AI849689 | |
| MAPK 8 | |
| JNK1 beta1 protein kinase | |
| mitogen activated protein kinase 8 | |
| protein kinase mitogen-activated 8 | |
| stress-activated protein kinase JNK1 | |
| p54 gamma | |
| SAPK gamma | |
| c-jun NH2-terminal kinase | |
| OTTMUSP00000019794 | |
| OTTMUSP00000019793 | |
| OTTMUSP00000019791 | |
| OTTMUSP00000019790 | |
| OTTHUMP00000019558 | |
| OTTHUMP00000019556 | |
| OTTHUMP00000019555 | |
| OTTHUMP00000019552 | |
| SAPK I | |
| PIR:A53063 | |
| protein kinase JNK I | |
| protein kinase JNK1 | |
| Stress-activated protein kinase JNK I | |
| mitogen activated protein kinase VIII | |
| protein kinase mitogen-activated VIII | |
| c-Jun N-terminal kinase | |
| c-Jun NH2-kinase | |
| c-Jun NH2-terminal kinase I | |
| c-Jun N-terminal kinase I | |
| JNK I | |
| JNK1 alpha protein kinase | |
| Jun NH2-terminal kinase 1 | |
| c-Jun NH2-terminal kinase 1 | |
| JNK1 alpha2 protein kinase | |
| MAPK8 | |
| Jun NH2-terminal kinase | |
| JNK1 beta protein kinase | |
| Jun NH2-terminal kinase I | |
| Stress-activated protein kinase JNK1 | |
| Stress-activated protein kinase JNK I | |
| RBPMS2 | |
| RNA-binding protein with multiple splicing 2 | |
| RNA-binding protein with multiple splicing II | |
| RBPMS2s | |
| similar to RIKEN cDNA 2400008B06 | |
| expressed sequence AI849689 | |
| JNK1alpha2 | |
| Pristane induced arthritis QTL 1 | |
| Pristane induced arthritis QTL I | |
| Pia I | |
| mitogen-activated protein kinase 8 transcript variant 2 | |
| Pia1 | |
| JNK1-alpha-1 | |
| chromosome | |
| scaffold | |
| zgc:112379 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 601158 |
|---|---|
| OMIM:601158 | |
| 61411 |
| Unigene ID | Hs.138211 |
|---|---|
| Mm.21495 | |
| Rn.4090 | |
| Rn.160441 | |
| Mm.441782 | |
| Hs.445864 | |
| Hs.522924 | |
| Hs.267445 | |
| Bt.14050 | |
| Dr.82505 |
| KEGG ID | hsa:5599 |
|---|---|
| mmu:26419 | |
| rno:116554 |
| Swiss-Prot Accession | P45983 |
|---|---|
| A1L4K2 | |
| Q544A0 | |
| Q91Y86 | |
| P49185 | |
| B5BTZ5 | |
| B7ZLV4 | |
| D3DX88 | |
| D3DX92 | |
| Q15709 | |
| Q15712 | |
| Q15713 | |
| Q308M2 | |
| Q7TSJ7 |
| EC Number | 2.7.11.24 |
|---|---|
| 2.7.1.- | |
| 2.7.1.37 | |
| 2.7.11.1 |
| GO ID | 0005524 |
|---|---|
| 0004705 | |
| 0042826 | |
| 0035033 | |
| 0004674 | |
| 0007254 | |
| 0007258 | |
| 0002755 | |
| 0002756 | |
| 0035666 | |
| 0008063 | |
| 0008633 | |
| 0006915 | |
| 0071260 | |
| 0045087 | |
| 0043066 | |
| 0032091 | |
| 0048011 | |
| 0001503 | |
| 0018105 | |
| 0018107 | |
| 0090045 | |
| 2000017 | |
| 0010628 | |
| 0031063 | |
| 0032880 | |
| 0051090 | |
| 0009411 | |
| 0046686 | |
| 0006950 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0005829 | |
| 0005739 | |
| 0005654 | |
| 0005634 | |
| 0004707 | |
| 0016301 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0048263 | |
| 0006954 | |
| 0031175 | |
| 0016310 | |
| 0045740 | |
| 2001235 | |
| 0030335 | |
| 0031116 | |
| 0006468 | |
| 0010468 | |
| 0006355 | |
| 0009408 | |
| 0042542 | |
| 0006970 | |
| 0007165 | |
| 0023014 | |
| 0033267 | |
| 0005737 | |
| 0032839 | |
| 0005622 | |
| 0043204 | |
| 0031982 | |
| 0043065 | |
| 0048545 | |
| 0008624 | |
| 0031558 | |
| 0006928 | |
| 0005515 | |
| 0004713 | |
| 0016469 | |
| 0046933 | |
| 0046961 | |
| 0004682 | |
| 0004691 | |
| 0015986 | |
| 0050775 |
| PIR ID | S43970 |
|---|---|
| S71097 | |
| S71099 |
| Swiss-Prot ID | MK08_MOUSE |
|---|---|
| MK08_RAT | |
| MK08_HUMAN | |
| Q544A0_MOUSE | |
| D3DX92_HUMAN | |
| D3DX88_HUMAN | |
| A1L4K2_HUMAN | |
| B5BTZ5_HUMAN | |
| B7ZLV4_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Extracellular |
| IPI ID | IPI00129682 |
|---|---|
| IPI00191803 | |
| IPI00003145 | |
| IPI00024672 | |
| IPI00220305 | |
| IPI00220306 | |
| IPI00854859 | |
| IPI00646929 | |
| IPI00639865 | |
| IPI00857698 | |
| IPI00775848 | |
| IPI00775931 | |
| IPI00775897 | |
| IPI00776030 | |
| IPI00764183 |
| Mouse chromosome position | 14 |
|---|---|
| 14 B |
| Rat chromosome position | 16p16 |
|---|
| Homologene ID | 56760 |
|---|
| MGI ID | 1346861 |
|---|---|
| 1328367 | |
| 2145699 | |
| 2143015 |
| RGD ID | 621506 |
|---|---|
| 61411 |
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 10q11.22 |
|---|
| Microarray ID | 100391_at |
|---|---|
| 104047_at | |
| 1440856_at | |
| 1457936_at |
| FunctionalClass | ATP binding |
|---|---|
| JUN kinase | |
| MAP kinase | |
| nucleotide binding | |
| protein binding | |
| protein serine/threonine kinase | |
| transferase | |
| hydrogen-transporting ATP synthase activity, rotational mechanism | |
| hydrogen-transporting ATPase activity, rotational mechanism | |
| kinase | |
| protein kinase | |
| protein-tyrosine kinase | |
| cAMP-dependent protein kinase | |
| protein kinase CK2 | |
| hydrogen ion transporting ATP synthase activity, rotational mechanism | |
| hydrogen ion transporting ATPase activity, rotational mechanism |
| Mus musculus Chromosome position | 14 B |
|---|---|
| 9 | |
| 14 |
| KEGG pathway | Insulin signaling pathway |
|---|---|
| Type II diabetes mellitus | |
| Focal adhesion | |
| Wnt signaling pathway | |
| Toll-like receptor signaling pathway | |
| MAPK signaling pathway | |
| Adipocytokine signaling pathway | |
| Colorectal cancer | |
| Fc epsilon RI signaling pathway | |
| GnRH signaling pathway | |
| Pancreatic cancer | |
| ErbB signaling pathway |
| Rattus norvegicus Chromosome position | 16p16 |
|---|
| Hugo Symbol | MAPK8 |
|---|
| Bos taurus Chromosome position | 28 |
|---|