| URN | urn:agi-llid:5879 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2276 |
| Name | Rac1 |
| Description | ras-related C3 botulinum toxin substrate 1 |
| Notes | The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. |
| Ariadne Ontology | Rac-CDC42 |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | GTP-dependent protein binding |
|---|---|
| enzyme binding | |
| thioesterase binding | |
| protein kinase binding | |
| Rab GTPase binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity |
| GO Cellular Component | membrane |
|---|---|
| Golgi membrane | |
| phagocytic cup | |
| extrinsic to plasma membrane | |
| ruffle membrane | |
| plasma membrane | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle | |
| melanosome | |
| lamellipodium |
| GO Biological Process | cell proliferation |
|---|---|
| viral reproduction | |
| regulation of defense response to virus by virus | |
| cell adhesion | |
| cellular component movement | |
| regulation of small GTPase mediated signal transduction | |
| positive regulation of Rho protein signal transduction | |
| intracellular signal transduction | |
| apoptotic signaling pathway | |
| small GTPase mediated signal transduction | |
| Rac protein signal transduction | |
| Wnt receptor signaling pathway, planar cell polarity pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of DNA replication | |
| regulation of hydrogen peroxide metabolic process | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| negative regulation of receptor-mediated endocytosis | |
| T cell costimulation | |
| positive regulation of lamellipodium assembly | |
| positive regulation of actin filament polymerization | |
| regulation of cell migration | |
| epithelial cell morphogenesis | |
| substrate adhesion-dependent cell spreading | |
| auditory receptor cell morphogenesis | |
| dendrite morphogenesis | |
| dopaminergic neuron differentiation | |
| platelet activation | |
| GTP catabolic process | |
| phagocytosis, engulfment | |
| engulfment of apoptotic cell | |
| cell-matrix adhesion | |
| cell motility | |
| cell migration | |
| mast cell chemotaxis | |
| cerebral cortex radially oriented cell migration | |
| embryonic olfactory bulb interneuron precursor migration | |
| apoptotic process | |
| actin cytoskeleton organization | |
| actin filament organization | |
| actin filament polymerization | |
| localization within membrane | |
| cell-cell junction organization | |
| ruffle assembly | |
| lamellipodium assembly | |
| cytoskeleton organization | |
| ruffle organization | |
| dendrite development | |
| chemotaxis | |
| axon guidance | |
| response to wounding | |
| inflammatory response | |
| hyperosmotic response | |
| negative regulation of interleukin-23 production | |
| regulation of respiratory burst | |
| anatomical structure morphogenesis | |
| anatomical structure arrangement | |
| cochlea morphogenesis | |
| blood coagulation | |
| endocytosis | |
| bone resorption |
| Pathway | Tight Junction Assembly (Claudins) |
|---|---|
| Tight Junction Assembly (JAMs) | |
| Adherens Junction Assembly (Cadherins) | |
| Adherens Junction Assembly (Nectin) | |
| FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling | |
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| FrizzledR -> JUN/PAX2 signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| FcIgER -> ELK-SRF signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| IL1R -> STAT3 signaling | |
| IL1R -> NF-kB signaling | |
| AGER -> CREB/SP1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| KIT -> MITF signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| GDNF -> HSF1 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| EDG2 -> ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| ROS and RNS in Regulation of Vasoconstriction and Vasodilation | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| ROS in Triggering Vascular Inflammation | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| TLR1/2/6 Expression Targets | |
| Fibronectin Expression Targets | |
| CD247 Expression Targets | |
| FCGR3A Expression Targets | |
| Dopamine/Gi Expression Targets | |
| S100A Expression Targets | |
| S100B Expression Targets | |
| S100P Expression Target | |
| HMGB1 Expression Targets | |
| TTR Expression Targets | |
| AREG/AP-1 Expression Targets | |
| AREG/NFATC Expression Target | |
| BTC/NFATC Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| HBEGF/MEF/MYOD Expression Target | |
| HBEGF/TP53 Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/MEF/MYOD Expression Targets | |
| NRG1/TP53 Expression Target | |
| TGFA/MEF/MYOD/NFATC Expression Targets | |
| TGFA/TP53 Expression Targets | |
| GDNF/HSF1 Expression Targets | |
| IGF2/MEF/MYOD Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| CTGF/NCOR2 Expression Target | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| AREG/CREB/CREBBP Expression Targets | |
| AREG/NCOR2 Expression Targets | |
| EGF/NCOR2 Expression Target | |
| EREG/CREB Expression Target | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF1/NCOR2 Expression Target | |
| FGF2/NCOR2 Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| FGF23/NCOR2 Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFC/CREB Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| VEGFA/NCOR2 Expression Target | |
| ANGPT1/CREB/CREBBP Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| FIGF/NCOR2 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| IL16/ATF/CREB/CREBBP Expression Target | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| CD80/ATF/CREB/CREBBP Expression Targets | |
| CD86/ATF/CREB/CREBBP Expression Targets | |
| CD72/CREB/CREBBP Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| IL1A Expression Targets | |
| WNT5A Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| LPA Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| BTC/AP-1/ATF/CREB Expression Targets | |
| p38 MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| the planar cell polarity Wnt signaling pathway | |
| Wnt signaling, the planar cell polarity pathway | |
| p38 MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | Rac-CDC42 |
|---|---|
| cell proliferation | |
| viral reproduction | |
| regulation of defense response to virus by virus | |
| cell adhesion | |
| cellular component movement | |
| regulation of small GTPase mediated signal transduction | |
| positive regulation of Rho protein signal transduction | |
| intracellular signal transduction | |
| apoptotic signaling pathway | |
| small GTPase mediated signal transduction | |
| Rac protein signal transduction | |
| Wnt receptor signaling pathway, planar cell polarity pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of DNA replication | |
| regulation of hydrogen peroxide metabolic process | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| negative regulation of receptor-mediated endocytosis | |
| T cell costimulation | |
| positive regulation of lamellipodium assembly | |
| positive regulation of actin filament polymerization | |
| regulation of cell migration | |
| epithelial cell morphogenesis | |
| substrate adhesion-dependent cell spreading | |
| auditory receptor cell morphogenesis | |
| dendrite morphogenesis | |
| dopaminergic neuron differentiation | |
| platelet activation | |
| GTP catabolic process | |
| phagocytosis, engulfment | |
| engulfment of apoptotic cell | |
| cell-matrix adhesion | |
| cell motility | |
| cell migration | |
| mast cell chemotaxis | |
| cerebral cortex radially oriented cell migration | |
| embryonic olfactory bulb interneuron precursor migration | |
| apoptotic process | |
| actin cytoskeleton organization | |
| actin filament organization | |
| actin filament polymerization | |
| localization within membrane | |
| cell-cell junction organization | |
| ruffle assembly | |
| lamellipodium assembly | |
| cytoskeleton organization | |
| ruffle organization | |
| dendrite development | |
| chemotaxis | |
| axon guidance | |
| response to wounding | |
| inflammatory response | |
| hyperosmotic response | |
| negative regulation of interleukin-23 production | |
| regulation of respiratory burst | |
| anatomical structure morphogenesis | |
| anatomical structure arrangement | |
| cochlea morphogenesis | |
| blood coagulation | |
| endocytosis | |
| bone resorption | |
| GTP-dependent protein binding | |
| enzyme binding | |
| thioesterase binding | |
| protein kinase binding | |
| Rab GTPase binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity | |
| membrane | |
| Golgi membrane | |
| phagocytic cup | |
| extrinsic to plasma membrane | |
| ruffle membrane | |
| plasma membrane | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle | |
| melanosome | |
| lamellipodium | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| MedScan ID | 5879 |
|---|
| Hugo ID | 9801 |
|---|
| Human chromosome position | 7p22 |
|---|
| LocusLink ID | 5879 |
|---|---|
| 19353 | |
| 363875 | |
| 100781 | |
| 171377 | |
| 52352 | |
| 281440 | |
| 327204 | |
| 393898 |
| Alias | MIG5 |
|---|---|
| Rac-1 | |
| TC-25 | |
| p21-Rac1 | |
| ras-related C3 botulinum toxin substrate 1 | |
| ras-like protein TC25 | |
| cell migration-inducing gene 5 protein | |
| AL023026 | |
| D5Ertd559e | |
| rho family, small GTP binding protein Rac1 | |
| ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1) | |
| TC25 | |
| rac1c | |
| RAS-related C3 botulinum substrate I | |
| ras-related C3 botulinum toxin substrate 1 isoform Rac I | |
| rho family, small GTP binding Rac | |
| RAS-related C3 botulinum substrate 1 | |
| ras-related C3 botulinum toxin substrate 1 isoform Rac1 | |
| ras-related C3 botulinum toxin substrate 1 isoform Rac1b | |
| ras-related C3 botulinum toxin substrate I | |
| small gtp binding protein rac1 | |
| Rac1B | |
| OTTMUSP00000022620 | |
| rho family, small GTP binding protein Rac I | |
| LOC136000 | |
| DNA segment, Chr 5, ERATO Doi 559, expressed | |
| GTP-binding protein rac1 | |
| LOC155330 | |
| MGC111543 | |
| migration-inducing gene 5 | |
| Rac(V12) | |
| GTP-binding protein rac I | |
| Rac1 | |
| migration-inducing protein 5 | |
| Rac I | |
| RAC1_HUMAN | |
| p21-Rac I | |
| migration-inducing protein V | |
| ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | |
| Ras-like protein TC25 | |
| expressed sequence AL023026 | |
| isoform rac1b | |
| rac1b splicing isoform | |
| splicing isoform rac1b | |
| MGC55823 | |
| chromosome | |
| fd16e02 | |
| scaffold | |
| wu:fd16e02 | |
| zgc:55823 | |
| zgc:55917 | |
| zgc:86934 | |
| RAC related | |
| RAC related (21.5 kD) | |
| RAC related (21.5 kD) (ced-10) | |
| ced-10 | |
| similar to CEll Death abnormality CED-10 | |
| similar to CEll Death abnormality CED-10, RAC related (21.5 kD) (ced-10) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 602048 |
|---|
| Unigene ID | Hs.413812 |
|---|---|
| Mm.292510 | |
| Mm.469963 | |
| Mm.475073 | |
| Rn.29157 | |
| Mm.342177 | |
| Mm.466548 | |
| Mm.74208 | |
| Hs.632900 | |
| Hs.633454 | |
| Hs.551925 | |
| Mm.432479 | |
| Bt.75763 | |
| Dr.117150 | |
| Dr.4711 |
| KEGG ID | hsa:5879 |
|---|---|
| mmu:19353 | |
| rno:363875 |
| Swiss-Prot Accession | A4D2P1 |
|---|---|
| P63000 | |
| A4D2P0 | |
| P63001 | |
| Q6RUV5 | |
| O95501 | |
| P15154 | |
| Q3Y4D3 | |
| Q5JAA8 | |
| Q9BTB4 | |
| Q59FQ0 | |
| Q3TLP8 | |
| Q8BPG5 | |
| Q8C4N8 | |
| Q9D859 | |
| Q923X0 | |
| AAB22206 |
| GO ID | 0005525 |
|---|---|
| 0030742 | |
| 0003924 | |
| 0019899 | |
| 0031996 | |
| 0031295 | |
| 0060071 | |
| 0030041 | |
| 0048532 | |
| 0009653 | |
| 0006915 | |
| 0002093 | |
| 0007411 | |
| 0007596 | |
| 0007155 | |
| 0048870 | |
| 0045216 | |
| 0007160 | |
| 0006928 | |
| 0021799 | |
| 0090103 | |
| 0048813 | |
| 0071542 | |
| 0021831 | |
| 0043652 | |
| 0003382 | |
| 0006972 | |
| 0006954 | |
| 0035556 | |
| 0030032 | |
| 0051668 | |
| 0032707 | |
| 0048261 | |
| 0048011 | |
| 0030168 | |
| 0035025 | |
| 0030838 | |
| 0010592 | |
| 0043552 | |
| 0030334 | |
| 0050690 | |
| 0010310 | |
| 0060263 | |
| 0051056 | |
| 0009611 | |
| 0097178 | |
| 0031529 | |
| 0007264 | |
| 0034446 | |
| 0016032 | |
| 0005829 | |
| 0019897 | |
| 0030027 | |
| 0042470 | |
| 0001891 | |
| 0005886 | |
| 0032587 | |
| 0017137 | |
| 0000166 | |
| 0019901 | |
| 0006184 | |
| 0030036 | |
| 0007015 | |
| 0045453 | |
| 0016477 | |
| 0008283 | |
| 0006935 | |
| 0007010 | |
| 0016358 | |
| 0006897 | |
| 0002551 | |
| 0006911 | |
| 0045740 | |
| 0000139 | |
| 0042995 | |
| 0005737 | |
| 0016023 | |
| 0031410 | |
| 0005622 | |
| 0016020 | |
| 0016601 | |
| 0008624 | |
| 0023034 | |
| 0005624 | |
| 0005515 | |
| 0015031 | |
| 0050775 | |
| 0005579 |
| PIR ID | A34788 |
|---|---|
| A60347 |
| Swiss-Prot ID | RAC1_HUMAN |
|---|---|
| RAC1_RAT | |
| RAC1_MOUSE | |
| A4D2P0_HUMAN | |
| A4D2P1_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Melanosome | |
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00010271 |
|---|---|
| IPI00219675 | |
| IPI00422092 | |
| IPI00761613 | |
| IPI00555566 | |
| IPI00394837 | |
| IPI00127408 | |
| IPI00780227 |
| Mouse chromosome position | 5 82.0 cM |
|---|
| Rat chromosome position | 12p11 |
|---|
| Homologene ID | 69035 |
|---|
| MGI ID | 97845 |
|---|---|
| 2141016 | |
| 1261850 |
| RGD ID | 619755 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 7p22 |
|---|
| Microarray ID | 101555_at |
|---|
| FunctionalClass | GTP binding |
|---|---|
| GTP-dependent protein binding | |
| GTPase | |
| nucleotide binding | |
| protein binding |
| Mus musculus Chromosome position | 5 82.0 cM |
|---|---|
| 5 |
| KEGG pathway | Adherens junction |
|---|---|
| Axon guidance | |
| B cell receptor signaling pathway | |
| Colorectal cancer | |
| Fc epsilon RI signaling pathway | |
| Focal adhesion | |
| Leukocyte transendothelial migration | |
| MAPK signaling pathway | |
| Natural killer cell mediated cytotoxicity | |
| Pancreatic cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| Toll-like receptor signaling pathway | |
| VEGF signaling pathway | |
| Wnt signaling pathway |
| Rattus norvegicus Chromosome position | 12p11 |
|---|
| Bos taurus Chromosome position | 25 |
|---|