| URN | urn:agi-llid:998 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1549 |
| Name | Cdc42 |
| Description | cell division cycle 42 homolog (S. cerevisiae) |
| Notes | small GTPase; involved in formation of cellular asymmetry [RGD] |
| Ariadne Ontology | Rac-CDC42 |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | GTP-dependent protein binding |
|---|---|
| apolipoprotein A-I receptor binding | |
| thioesterase binding | |
| protein kinase binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity |
| GO Cellular Component | membrane |
|---|---|
| Golgi membrane | |
| microtubule organizing center | |
| spindle midzone | |
| mitotic spindle | |
| apical part of cell | |
| midbody | |
| plasma membrane | |
| cell periphery | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| secretory granule | |
| cytoskeleton | |
| neuron projection | |
| filopodium | |
| neuronal cell body |
| GO Biological Process | establishment or maintenance of cell polarity |
|---|---|
| regulation of attachment of spindle microtubules to kinetochore | |
| organelle transport along microtubule | |
| regulation of mitosis | |
| positive regulation of cell cycle cytokinesis | |
| epithelial-mesenchymal cell signaling | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of epidermal growth factor receptor signaling pathway | |
| positive regulation of MAPK cascade | |
| positive regulation of JNK cascade | |
| small GTPase mediated signal transduction | |
| Rho protein signal transduction | |
| canonical Wnt receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of DNA replication | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| regulation of protein kinase activity | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| positive regulation of synapse structural plasticity | |
| positive regulation of hair follicle cell proliferation | |
| T cell costimulation | |
| positive regulation of muscle cell differentiation | |
| positive regulation of pseudopodium assembly | |
| positive regulation of neuron apoptotic process | |
| regulation of exocytosis | |
| positive regulation of intracellular protein transport | |
| regulation of filopodium assembly | |
| cell differentiation | |
| keratinocyte development | |
| muscle cell differentiation | |
| macrophage differentiation | |
| neuron fate determination | |
| GTP catabolic process | |
| cell-cell adhesion | |
| epithelial cell-cell adhesion | |
| establishment of cell polarity | |
| establishment or maintenance of apical-basal cell polarity | |
| actin cytoskeleton organization | |
| actin filament organization | |
| actin filament branching | |
| actin filament bundle assembly | |
| cellular protein localization | |
| nucleus localization | |
| adherens junction organization | |
| filopodium assembly | |
| Golgi organization | |
| response to glucose stimulus | |
| axon guidance | |
| negative regulation of gene expression | |
| negative regulation of protein complex assembly | |
| positive regulation of gene expression | |
| regulation of protein metabolic process | |
| regulation of protein stability | |
| regulation of protein catabolic process | |
| positive regulation of metalloenzyme activity | |
| keratinization | |
| submandibular salivary gland formation | |
| epidermis morphogenesis | |
| hair follicle morphogenesis | |
| sprouting angiogenesis | |
| hair follicle placode formation | |
| cardiac conduction system development | |
| nervous system development | |
| multicellular organism growth | |
| heart contraction | |
| blood coagulation | |
| endosomal transport | |
| establishment of Golgi localization | |
| nuclear migration | |
| regulation of protein heterodimerization activity |
| Pathway | Actin Cytoskeleton Assembly |
|---|---|
| Tight Junction Assembly (Claudins) | |
| Tight Junction Assembly (JAMs) | |
| Adherens Junction Assembly (Cadherins) | |
| Adherens Junction Assembly (Nectin) | |
| Endosomal Recycling | |
| FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling | |
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| AGER -> CREB/SP1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| KIT -> MITF signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| GDNF -> HSF1 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| TLR1/2/6 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| S100A Expression Targets | |
| S100B Expression Targets | |
| S100P Expression Target | |
| HMGB1 Expression Targets | |
| TTR Expression Targets | |
| AREG/AP-1 Expression Targets | |
| AREG/NFATC Expression Target | |
| BTC/NFATC Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| HBEGF/MEF/MYOD Expression Target | |
| HBEGF/TP53 Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/MEF/MYOD Expression Targets | |
| NRG1/TP53 Expression Target | |
| TGFA/MEF/MYOD/NFATC Expression Targets | |
| TGFA/TP53 Expression Targets | |
| VEGFA/NFATC Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| VEGFC/ATF Expression Target | |
| GDNF/HSF1 Expression Targets | |
| IGF2/MEF/MYOD Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| CTGF/NCOR2 Expression Target | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| AREG/CREB/CREBBP Expression Targets | |
| AREG/NCOR2 Expression Targets | |
| EGF/NCOR2 Expression Target | |
| EREG/CREB Expression Target | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF1/NCOR2 Expression Target | |
| FGF2/NCOR2 Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| FGF23/NCOR2 Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFC/CREB Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| VEGFA/NCOR2 Expression Target | |
| ANGPT1/CREB/CREBBP Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| FIGF/NCOR2 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| IL16/ATF/CREB/CREBBP Expression Target | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| CD80/ATF/CREB/CREBBP Expression Targets | |
| CD86/ATF/CREB/CREBBP Expression Targets | |
| CD72/CREB/CREBBP Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| BTC/AP-1/ATF/CREB Expression Targets | |
| p38 MAPK signaling pathway | |
| altered insulin secretion pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | Rac-CDC42 |
|---|---|
| establishment or maintenance of cell polarity | |
| regulation of attachment of spindle microtubules to kinetochore | |
| organelle transport along microtubule | |
| regulation of mitosis | |
| positive regulation of cell cycle cytokinesis | |
| epithelial-mesenchymal cell signaling | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of epidermal growth factor receptor signaling pathway | |
| positive regulation of MAPK cascade | |
| positive regulation of JNK cascade | |
| small GTPase mediated signal transduction | |
| Rho protein signal transduction | |
| canonical Wnt receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of DNA replication | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| regulation of protein kinase activity | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| positive regulation of synapse structural plasticity | |
| positive regulation of hair follicle cell proliferation | |
| T cell costimulation | |
| positive regulation of muscle cell differentiation | |
| positive regulation of pseudopodium assembly | |
| positive regulation of neuron apoptotic process | |
| regulation of exocytosis | |
| positive regulation of intracellular protein transport | |
| regulation of filopodium assembly | |
| cell differentiation | |
| keratinocyte development | |
| muscle cell differentiation | |
| macrophage differentiation | |
| neuron fate determination | |
| GTP catabolic process | |
| cell-cell adhesion | |
| epithelial cell-cell adhesion | |
| establishment of cell polarity | |
| establishment or maintenance of apical-basal cell polarity | |
| actin cytoskeleton organization | |
| actin filament organization | |
| actin filament branching | |
| actin filament bundle assembly | |
| cellular protein localization | |
| nucleus localization | |
| adherens junction organization | |
| filopodium assembly | |
| Golgi organization | |
| response to glucose stimulus | |
| axon guidance | |
| negative regulation of gene expression | |
| negative regulation of protein complex assembly | |
| positive regulation of gene expression | |
| regulation of protein metabolic process | |
| regulation of protein stability | |
| regulation of protein catabolic process | |
| positive regulation of metalloenzyme activity | |
| keratinization | |
| submandibular salivary gland formation | |
| epidermis morphogenesis | |
| hair follicle morphogenesis | |
| sprouting angiogenesis | |
| hair follicle placode formation | |
| cardiac conduction system development | |
| nervous system development | |
| multicellular organism growth | |
| heart contraction | |
| blood coagulation | |
| endosomal transport | |
| establishment of Golgi localization | |
| nuclear migration | |
| regulation of protein heterodimerization activity | |
| GTP-dependent protein binding | |
| apolipoprotein A-I receptor binding | |
| thioesterase binding | |
| protein kinase binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity | |
| membrane | |
| Golgi membrane | |
| microtubule organizing center | |
| spindle midzone | |
| mitotic spindle | |
| apical part of cell | |
| midbody | |
| plasma membrane | |
| cell periphery | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| secretory granule | |
| cytoskeleton | |
| neuron projection | |
| filopodium | |
| neuronal cell body | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| MedScan ID | 998 |
|---|---|
| 12540 | |
| 635133 |
| Hugo ID | 1736 |
|---|
| Human chromosome position | 1p36.1 |
|---|
| LocusLink ID | 998 |
|---|---|
| 12540 | |
| 64465 | |
| 100285 | |
| 100196 | |
| 281676 | |
| 532712 | |
| 336839 | |
| 393605 | |
| 553175 |
| Alias | G25K |
|---|---|
| CDC42Hs | |
| RP1-224A6.5 | |
| cell division control protein 42 homolog | |
| G25K GTP-binding protein | |
| GTP-binding protein, 25kD | |
| growth-regulating protein | |
| small GTP binding protein CDC42 | |
| dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) | |
| dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) | |
| AI747189 | |
| AU018915 | |
| RP23-246F18.2 | |
| cell division cycle 42 homolog | |
| Rho GTPase Cdc42 | |
| G25P | |
| G25K GTP-binding protein, placental isoform | |
| G25P_HUMAN | |
| GTP-binding G25K, placental | |
| OTTHUMP00000002926 | |
| cell division cycle 42 isoform II | |
| OTTHUMP00000002834 | |
| 25 kDa GTP-binding protein | |
| cell division cycle 42 isoform I | |
| CDC42 | |
| Cdc42 Rho GTPase | |
| cell division cycle 42 | |
| cell division cycle 42 (GTP binding protein, 25kD) | |
| cell division cycle 42 (GTP binding protein, 25kDa) | |
| cell division cycle 42 homolog (S. cerevisiae) | |
| cell division cycle 42 isoform 1 | |
| cell division cycle 42 isoform 2 | |
| cell division cycle 42 (GTP binding protein) | |
| OTTMUSP00000010388 | |
| OTTHUMP00000002927 | |
| cell division cycle 42 (GTP-binding protein, 25kD) | |
| small GTP binding protein | |
| Cdc42 protein homolog | |
| MGC63918 | |
| cdc42a | |
| chromosome | |
| fb07d08 | |
| scaffold | |
| wu:fb07d08 | |
| zgc:63918 | |
| hypothetical protein MGC63918 | |
| ras-like protein Cdc42a |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 116952 |
|---|
| Unigene ID | Hs.467637 |
|---|---|
| Mm.1022 | |
| Mm.447553 | |
| Rn.228625 | |
| Rn.60067 | |
| Hs.690198 | |
| Mm.471693 | |
| Mm.323783 | |
| Mm.426418 | |
| Mm.381404 | |
| Hs.597524 | |
| Bt.56113 | |
| Dr.104797 |
| KEGG ID | hsa:998 |
|---|---|
| mmu:12540 | |
| rno:64465 |
| Swiss-Prot Accession | P60953 |
|---|---|
| P60766 | |
| Q8CFN2 | |
| P21181 | |
| P25763 | |
| Q7L8R5 | |
| Q9UDI2 | |
| A2A9U6 | |
| Q3THZ7 | |
| Q3TJK6 | |
| Q545V0 | |
| Q6P201 | |
| Q8BQ51 | |
| Q6P9Y3 | |
| Q71TW5 | |
| Q3UL78 | |
| Q99JI7 | |
| Q5JYX0 | |
| Q9UJM0 | |
| Q9UJM1 | |
| P50290 |
| EC Number | 3.6.5.1 |
|---|---|
| 3.6.5.2 | |
| 3.6.5.3 | |
| 3.6.5.4 |
| GO ID | 0005525 |
|---|---|
| 0030742 | |
| 0003924 | |
| 0034191 | |
| 0031435 | |
| 0019901 | |
| 0031996 | |
| 0006184 | |
| 0007030 | |
| 0031295 | |
| 0030036 | |
| 0051017 | |
| 0034332 | |
| 0007411 | |
| 0007596 | |
| 0060070 | |
| 0003161 | |
| 0034613 | |
| 0007173 | |
| 0090136 | |
| 0060684 | |
| 0051683 | |
| 0035088 | |
| 0007163 | |
| 0046847 | |
| 0031069 | |
| 0060789 | |
| 0060047 | |
| 0031424 | |
| 0003334 | |
| 0030225 | |
| 0035264 | |
| 0042692 | |
| 0042059 | |
| 0010629 | |
| 0031333 | |
| 0048664 | |
| 0007097 | |
| 0072384 | |
| 0045740 | |
| 0046330 | |
| 0071777 | |
| 0010628 | |
| 0071338 | |
| 0051149 | |
| 0033138 | |
| 0043552 | |
| 0031274 | |
| 0051988 | |
| 0051489 | |
| 0007088 | |
| 0042176 | |
| 0043497 | |
| 0045859 | |
| 0031647 | |
| 0051056 | |
| 0007264 | |
| 0000139 | |
| 0045177 | |
| 0005737 | |
| 0005829 | |
| 0030175 | |
| 0005815 | |
| 0030496 | |
| 0072686 | |
| 0043005 | |
| 0043025 | |
| 0005886 | |
| 0030141 | |
| 0051233 | |
| 0000166 | |
| 0007266 | |
| 0090135 | |
| 0007015 | |
| 0030154 | |
| 0016337 | |
| 0016197 | |
| 0048730 | |
| 0007399 | |
| 0051647 | |
| 0043410 | |
| 0090316 | |
| 0048554 | |
| 0043525 | |
| 0001934 | |
| 0051835 | |
| 0051246 | |
| 0002040 | |
| 0071944 | |
| 0042995 | |
| 0005856 | |
| 0005622 | |
| 0016020 | |
| 0030010 | |
| 0017157 | |
| 0009749 | |
| 0060661 | |
| 0051301 | |
| 0005515 | |
| 0001558 | |
| 0051318 | |
| 0015031 | |
| 0007049 | |
| 0000910 | |
| 0000074 | |
| 0005579 |
| PIR ID | A36382 |
|---|---|
| A39265 |
| Swiss-Prot ID | CDC42_HUMAN |
|---|---|
| CDC42_MOUSE | |
| CDC42_RAT |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm | |
| cytoskeleton | |
| centrosome | |
| spindle | |
| Midbody | |
| Plasma membrane |
| IPI ID | IPI00007189 |
|---|---|
| IPI00016786 | |
| IPI00113849 | |
| IPI00120193 | |
| IPI00285606 | |
| IPI00388289 | |
| IPI00642590 |
| Mouse chromosome position | 4 66.75 cM |
|---|
| Rat chromosome position | 5q36 |
|---|
| Homologene ID | 123986 |
|---|---|
| 1357 |
| MGI ID | 106211 |
|---|---|
| 2140354 | |
| 2140443 |
| RGD ID | 71043 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 1p36.1 |
|---|
| Microarray ID | 94105_at |
|---|---|
| 1435807_at |
| FunctionalClass | GTP binding |
|---|---|
| GTPase | |
| nucleotide binding | |
| protein binding | |
| GTP-dependent protein binding |
| Mus musculus Chromosome position | 4 66.75 cM |
|---|---|
| 4 |
| KEGG pathway | Adherens junction |
|---|---|
| Axon guidance | |
| Focal adhesion | |
| GnRH signaling pathway | |
| Leukocyte transendothelial migration | |
| MAPK signaling pathway | |
| Pancreatic cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| T cell receptor signaling pathway | |
| Tight junction | |
| VEGF signaling pathway |
| Rattus norvegicus Chromosome position | 5q36 |
|---|
| Bos taurus Chromosome position | 2 |
|---|