| URN | urn:agi-llid:4216 |
|---|---|
| Total Entities | 0 |
| Connectivity | 126 |
| Name | Map3k4 |
| Description | mitogen activated protein kinase kinase kinase 4 (predicted) |
| Notes | The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. |
| Ariadne Ontology | MAP3K |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| metal ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase kinase kinase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| perinuclear region of cytoplasm |
| GO Biological Process | activation of MAPKK activity |
|---|---|
| positive regulation of JUN kinase activity | |
| intracellular protein kinase cascade | |
| MAPK cascade | |
| JNK cascade | |
| chorionic trophoblast cell differentiation | |
| protein phosphorylation | |
| phosphorylation | |
| response to stress | |
| regulation of gene expression | |
| male germ-line sex determination | |
| placenta development | |
| determination of dorsal identity |
| Pathway | c-Jun N-terminal kinases MAPK signaling pathway |
|---|---|
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | MAP3K |
|---|---|
| activation of MAPKK activity | |
| positive regulation of JUN kinase activity | |
| intracellular protein kinase cascade | |
| MAPK cascade | |
| JNK cascade | |
| chorionic trophoblast cell differentiation | |
| protein phosphorylation | |
| phosphorylation | |
| response to stress | |
| regulation of gene expression | |
| male germ-line sex determination | |
| placenta development | |
| determination of dorsal identity | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase kinase kinase activity | |
| cytoplasm | |
| perinuclear region of cytoplasm |
| Source | Curated |
|---|---|
| RGD modified | |
| ResNet |
| MedScan ID | 4216 |
|---|---|
| 21364 |
| Hugo ID | 6856 |
|---|
| Human chromosome position | 6q26 |
|---|
| LocusLink ID | 4216 |
|---|---|
| 26407 | |
| 308106 | |
| 21364 | |
| 17272 | |
| 27882 | |
| 511779 | |
| 30495 | |
| 325488 | |
| 334747 | |
| 561337 | |
| 570131 |
| Alias | MTK1 |
|---|---|
| MEKK4 | |
| MAPKKK4 | |
| PRO0412 | |
| RP3-473J16.4 | |
| mitogen-activated protein kinase kinase kinase 4 | |
| MEKK 4 | |
| MEK kinase 4 | |
| MAP three kinase 1 | |
| MAP/ERK kinase kinase 4 | |
| MAPK/ERK kinase kinase 4 | |
| predicted protein of HQ0412 | |
| SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of | |
| dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) | |
| Tas | |
| RP17 | |
| Mek4b | |
| Rp17a | |
| D17Rp17 | |
| D17Rp17e | |
| mKIAA0213 | |
| T-associated sex reversal | |
| mitogen activated protein kinase kinase kinase 4 | |
| mitogen-activated protein kinase kinase kinase IV | |
| MTK I | |
| OTTHUMP00000017559 | |
| OTTHUMP00000017560 | |
| MEK kinase IV | |
| SSK2/SSK22 MAP kinase kinase kinase, , homolog of | |
| DNA segment, Chr 17, Roswell Park-17, expressed | |
| RP3-473J16.1 | |
| FLJ42439 | |
| homolog of yeast SSK2/SSK22 MAP kinase kinase kinase | |
| KIAA0213 | |
| MAP three kinase I | |
| MAP/ERK kinase kinase 4 isoform a | |
| MAP/ERK kinase kinase 4 isoform b | |
| MAP/ERK kinase kinase IV | |
| Map3k4 | |
| MAPK/ ERK kinase kinase 4 | |
| MAPK/ ERK kinase kinase IV | |
| mitogen activated protein kinase kinase kinase 4 (predicted) | |
| cb135 | |
| fa02f11 | |
| wu:fa02f11 | |
| chromosome | |
| fc83c01 | |
| scaffold | |
| wu:fc83c01 | |
| LOC561337 | |
| similar to mitogen-activated protein kinase kinase kinase 4 isoform b | |
| LOC570131 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 602425 |
|---|
| Unigene ID | Hs.390428 |
|---|---|
| Mm.28587 | |
| Rn.66100 | |
| Mm.386946 | |
| Bt.48616 | |
| Dr.109650 | |
| Dr.75420 | |
| Dr.106221 |
| KEGG ID | hsa:4216 |
|---|---|
| mmu:26407 | |
| rno:308106 |
| Swiss-Prot Accession | Q9P1M2 |
|---|---|
| Q9Y6R4 | |
| O08648 | |
| D3ZGU6 | |
| O08649 | |
| O70124 | |
| Q6PDG6 | |
| A6H8W0 | |
| B7ZLD3 | |
| B9EG75 | |
| Q5VTT8 | |
| Q5VTT9 | |
| Q92612 | |
| Q9H408 | |
| Q3UZV9 | |
| Q60671 | |
| Q80U64 | |
| Q8K4X6 | |
| Q9CRU1 |
| EC Number | 2.7.11.25 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004709 | |
| 0046872 | |
| 0004672 | |
| 0007254 | |
| 0000186 | |
| 0007243 | |
| 0019100 | |
| 0043507 | |
| 0006950 | |
| 0005737 | |
| 0048471 | |
| 0016301 | |
| 0000166 | |
| 0004674 | |
| 0016740 | |
| 0016772 | |
| 0060718 | |
| 0048263 | |
| 0016310 | |
| 0001890 | |
| 0006468 | |
| 0010468 | |
| 0000165 | |
| 0000287 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0004713 |
| PIR ID | T03022 |
|---|
| Swiss-Prot ID | M3K4_MOUSE |
|---|---|
| M3K4_HUMAN | |
| Q9P1M2_HUMAN | |
| Q6PDG6_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| perinuclear region |
| IPI ID | IPI00623304 |
|---|---|
| IPI00875136 | |
| IPI00186536 | |
| IPI00386260 | |
| IPI00873480 | |
| IPI00647525 | |
| IPI00119175 | |
| IPI00230708 | |
| IPI00359194 | |
| IPI00870607 |
| Mouse chromosome position | 17 8.42 cM |
|---|---|
| 17 6.5 cM |
| Rat chromosome position | 1q11 |
|---|
| Homologene ID | 31346 |
|---|
| MGI ID | 1346875 |
|---|---|
| 109592 | |
| 90953 |
| RGD ID | 1311192 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 6q26 |
|---|
| Microarray ID | 104272_s_at |
|---|---|
| 161568_f_at |
| FunctionalClass | ATP binding |
|---|---|
| MAP kinase kinase kinase | |
| magnesium ion binding | |
| nucleotide binding | |
| protein serine/threonine kinase | |
| transferase | |
| kinase | |
| metal ion binding | |
| protein kinase | |
| protein-tyrosine kinase |
| Mus musculus Chromosome position | 17 6.5 cM |
|---|
| KEGG pathway | MAPK signaling pathway |
|---|---|
| GnRH signaling pathway |
| Rattus norvegicus Chromosome position | 1q11 |
|---|
| Bos taurus Chromosome position | 9 |
|---|