| URN | urn:agi-llid:5602 |
|---|---|
| Total Entities | 0 |
| Connectivity | 288 |
| Name | Mapk10 |
| Description | mitogen activated protein kinase 10 |
| Notes | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Ariadne Ontology | JNK |
|---|---|
| Secreted proteins |
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| transferase activity | |
| kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| JUN kinase activity | |
| MAP kinase kinase activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| plasma membrane | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus |
| GO Biological Process | activation of MAPK activity |
|---|---|
| signal transduction | |
| signal transduction by phosphorylation | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| protein phosphorylation | |
| JUN phosphorylation | |
| phosphorylation | |
| innate immune response |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EctodysplasinR -> AP-1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| FrizzledR -> JUN/PAX2 signaling | |
| TGFBR -> AP-1 signaling | |
| TLR -> AP-1 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| EDG3/5 -> AP-1/ELK-SRF signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| EphrinB -> JUN signaling | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| WNT7A Expression Targets | |
| WNT1 Expression Targets | |
| WNT4 Expression Targets | |
| WNT3A Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| FASLG Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| AREG/AP-1 Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| HBEGF/TP53 Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/TP53 Expression Target | |
| TGFA/TP53 Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| FLT3LG/AP-1/CREB/CREBBP Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| HBEGF/CREB/MYC Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF8/AP-1/CREB/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF18/AP-1/CREB Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGFB/AP-1/CREB/MYC Expression Target | |
| PDGFD/AP-1 Expression Targets | |
| ANGPT2/AP-1/CREBBP/MYC Expression Targets | |
| FIGF/AP-1 Expression Target | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| S1P Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| WNT5A Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| BTC/AP-1/ATF/CREB Expression Targets | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway |
| Group | JNK |
|---|---|
| activation of MAPK activity | |
| signal transduction | |
| signal transduction by phosphorylation | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| regulation of sequence-specific DNA binding transcription factor activity | |
| protein phosphorylation | |
| JUN phosphorylation | |
| phosphorylation | |
| innate immune response | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase activity | |
| JUN kinase activity | |
| MAP kinase kinase activity | |
| nucleoplasm | |
| plasma membrane | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 5602 |
|---|
| Hugo ID | 6872 |
|---|
| Human chromosome position | 4q22.1-q23 |
|---|
| LocusLink ID | 5602 |
|---|---|
| 26414 | |
| 25272 | |
| 20368 |
| Alias | JNK3 |
|---|---|
| JNK3A | |
| PRKM10 | |
| SAPK1b | |
| p493F12 | |
| p54bSAPK | |
| mitogen-activated protein kinase 10 | |
| MAPK 10 | |
| MAP kinase 10 | |
| MAP kinase p49 3F12 | |
| JNK3 alpha protein kinase | |
| c-Jun N-terminal kinase 3 | |
| stress-activated protein kinase 1b | |
| stress activated protein kinase beta | |
| stress-activated protein kinase JNK3 | |
| Serk2 | |
| JNK3B1 | |
| JNK3B2 | |
| SAPK(beta) | |
| C230008H04Rik | |
| SAPK/Erk/kinase 2 | |
| JNK3 beta1 protein kinase | |
| JNK3 beta2 protein kinase | |
| mitogen activated protein kinase 10 | |
| SAPb | |
| SAPKC | |
| p54-beta | |
| SAPK-beta | |
| p49SAPK | |
| p49MAPK | |
| OTTMUSP00000018412 | |
| OTTMUSP00000018411 | |
| OTTMUSP00000018410 | |
| OTTMUSP00000018409 | |
| OTTMUSP00000017557 | |
| OTTHUMP00000161182 | |
| p54b SAPK | |
| OTTHUMP00000161183 | |
| protein kinase mitogen-activated 10 | |
| SAPK/Erk/kinase II | |
| OTTHUMP00000161181 | |
| MGC50974 | |
| stress activated protein kinase JNK3 | |
| FLJ33785 | |
| C230008H04 | |
| c-Jun kinase 3 | |
| c-Jun kinase III | |
| MK10 | |
| FLJ12099 | |
| OTTHUMP00000161180 | |
| JNK3 alpha2 protein kinase | |
| MAPK10 | |
| c-Jun N-terminal kinase III | |
| MK10_HUMAN | |
| kinase alpha-2 | |
| JNK3A2 | |
| JNK3A1 | |
| MAP kinase | |
| Stress-activated protein kinase JNK3 | |
| kinase alpha-2 | |
| MAP kinase p49 3F12 | |
| RIKEN cDNA C230008H04 gene | |
| PRKM10s | |
| MAPK10s | |
| JNK3-alpha-1 | |
| JNK3alpha1 | |
| stress activated kinase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602897 |
|---|---|
| 606369 | |
| OMIM:602897 |
| Unigene ID | Hs.125503 |
|---|---|
| Mm.39253 | |
| Mm.472459 | |
| Rn.9911 | |
| Hs.723352 | |
| Mm.265834 | |
| Hs.25209 |
| KEGG ID | hsa:5602 |
|---|---|
| mmu:26414 | |
| rno:25272 |
| Swiss-Prot Accession | P53779 |
|---|---|
| A8MWW6 | |
| Q8C9D4 | |
| Q80W82 | |
| Q61831 | |
| B0VXR6 | |
| P49187 | |
| A6NFS3 | |
| A6NG28 | |
| B3KQ94 | |
| Q15707 | |
| Q49AP1 | |
| A8MUN8 | |
| Q499Y8 | |
| Q3TQZ7 | |
| Q80W80 | |
| Q80W81 | |
| Q8BQV0 |
| EC Number | 2.7.11.24 |
|---|---|
| 2.7.1.37 | |
| 2.7.1.- |
| GO ID | 0005524 |
|---|---|
| 0004705 | |
| 0004708 | |
| 0007254 | |
| 0002755 | |
| 0002756 | |
| 0035666 | |
| 0008063 | |
| 0000187 | |
| 0045087 | |
| 0051090 | |
| 0007165 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0005829 | |
| 0005739 | |
| 0005654 | |
| 0005886 | |
| 0016301 | |
| 0000166 | |
| 0004674 | |
| 0016740 | |
| 0007258 | |
| 0016310 | |
| 0006468 | |
| 0023014 | |
| 0005737 | |
| 0004707 | |
| 0005634 | |
| 0004672 | |
| 0005515 | |
| 0004713 | |
| 0004682 | |
| 0004691 |
| PIR ID | S43969 |
|---|---|
| S71104 |
| Swiss-Prot ID | MK10_RAT |
|---|---|
| MK10_HUMAN | |
| A6NG28_HUMAN | |
| A8MUN8_HUMAN | |
| B3KQ94_HUMAN | |
| Q80W82_MOUSE | |
| Q8C9D4_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane | |
| Nucleus |
| IPI ID | IPI00191810 |
|---|---|
| IPI00003148 | |
| IPI00023547 | |
| IPI00376687 | |
| IPI00148567 | |
| IPI00762375 | |
| IPI00775773 | |
| IPI00873275 | |
| IPI00795397 | |
| IPI00224039 | |
| IPI00623629 | |
| IPI00406158 | |
| IPI00776102 | |
| IPI00780268 |
| Mouse chromosome position | 5 |
|---|---|
| 5 E5 |
| Rat chromosome position | 14p22 |
|---|
| Homologene ID | 56439 |
|---|
| MGI ID | 1346863 |
|---|---|
| 107554 |
| RGD ID | 3663 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| KEGG pathway | Insulin signaling pathway |
|---|---|
| Type II diabetes mellitus | |
| Focal adhesion | |
| Wnt signaling pathway | |
| Toll-like receptor signaling pathway | |
| MAPK signaling pathway | |
| Adipocytokine signaling pathway |