| URN | urn:agi-llid:23079 |
|---|---|
| Connectivity | 9 |
| Name | Tln2 |
| Description | talin 2 |
| Notes | This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq] |
| Pathway | integrin mediated signaling pathway |
|---|---|
| integrin mediated signaling pathway |
| GO Molecular Function | structural molecule activity |
|---|---|
| structural constituent of cytoskeleton | |
| actin binding | |
| insulin receptor binding |
| GO Cellular Component | synapse |
|---|---|
| membrane | |
| plasma membrane | |
| ruffle | |
| cytoplasm | |
| cytoskeleton | |
| actin cytoskeleton | |
| cell junction | |
| cell-cell junction | |
| focal adhesion |
| GO Biological Process | cell adhesion |
|---|---|
| cytoskeletal anchoring at plasma membrane | |
| cell-cell junction assembly |
| Ariadne Ontology | Actin-based cytoskeleton assembly |
|---|
| Group | Actin-based cytoskeleton assembly |
|---|---|
| synapse | |
| structural molecule activity | |
| cell adhesion | |
| cytoskeletal anchoring at plasma membrane | |
| cell-cell junction assembly | |
| structural constituent of cytoskeleton | |
| actin binding | |
| insulin receptor binding | |
| membrane | |
| plasma membrane | |
| ruffle | |
| cytoplasm | |
| cytoskeleton | |
| actin cytoskeleton | |
| cell junction | |
| cell-cell junction | |
| focal adhesion |
| MedScan ID | 23079 |
|---|
| Hugo ID | 15447 |
|---|
| Human chromosome position | 15q15-q21 |
|---|
| LocusLink ID | 23079 |
|---|---|
| 83660 | |
| 70549 | |
| 315776 |
| Alias | ILWEQ |
|---|---|
| KIAA0320 | |
| DKFZp451B1011 | |
| DKFZp686I0976 | |
| DKFZp686K0979 | |
| talin-2 | |
| AI507121 | |
| AI787438 | |
| AL118320 | |
| MGC100340 | |
| mKIAA0320 | |
| 5730421P04Rik | |
| RGD1565416 | |
| talin 2 | |
| 5730421P04 | |
| LOC197002 | |
| LOC434411 | |
| LOC639214 | |
| talin II | |
| TLN2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607349 |
|---|
| Mouse chromosome position | 9 |
|---|
| GO ID | 0003779 |
|---|---|
| 0005158 | |
| 0005200 | |
| 0005198 | |
| 0007155 | |
| 0007043 | |
| 0007016 | |
| 0015629 | |
| 0005911 | |
| 0005737 | |
| 0005925 | |
| 0005886 | |
| 0001726 | |
| 0045202 | |
| 0030054 | |
| 0005856 | |
| 0016020 |
| Rat chromosome position | 8q24 |
|---|
| Swiss-Prot Accession | Q9Y4G6 |
|---|---|
| Q3TN69 | |
| Q68FD6 | |
| Q71LX4 | |
| Q8CDM9 | |
| Q3TKJ2 | |
| Q6PB69 | |
| Q8CHG4 | |
| Q9CS79 | |
| Q8BWK0 | |
| A6NLB8 |
| Unigene ID | Hs.569438 |
|---|---|
| Hs.610975 | |
| Mm.33645 |
| KEGG ID | hsa:83660 |
|---|---|
| mmu:70549 | |
| rno:315776 |
| Swiss-Prot ID | TLN2_MOUSE |
|---|---|
| TLN2_HUMAN | |
| Q68FD6_MOUSE | |
| Q8CDM9_MOUSE | |
| Q3TN69_MOUSE |
| Cell Localization | Cell junction |
|---|---|
| focal adhesion | |
| synapse | |
| Cell membrane | |
| Cytoplasm | |
| cytoskeleton |
| IPI ID | IPI00421218 |
|---|---|
| IPI00219299 | |
| IPI00752419 | |
| IPI00318182 | |
| IPI00405522 | |
| IPI00229647 | |
| IPI00387880 | |
| IPI00569296 | |
| IPI00768415 | |
| IPI00370137 |
| Homologene ID | 56692 |
|---|
| RGD ID | 1565416 |
|---|
| MGI ID | 1917799 |
|---|