| URN | urn:agi-llid:54751 |
|---|---|
| Connectivity | 37 |
| Name | Fblim1 |
| Description | filamin binding LIM protein 1 |
| Notes | This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] |
| Pathway | integrin mediated signaling pathway |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| zinc ion binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cell cortex | |
| cytosol | |
| cytoskeleton | |
| cell junction | |
| focal adhesion |
| GO Biological Process | cell adhesion |
|---|---|
| regulation of cell shape |
| Ariadne Ontology | ECM-Cell adhesion proteins |
|---|
| Group | ECM-Cell adhesion proteins |
|---|---|
| cell adhesion | |
| regulation of cell shape | |
| metal ion binding | |
| zinc ion binding | |
| cytoplasm | |
| cell cortex | |
| cytosol | |
| cytoskeleton | |
| cell junction | |
| focal adhesion |
| MedScan ID | 54751 |
|---|
| Hugo ID | 24686 |
|---|
| Human chromosome position | 1p36.21 |
|---|
| LocusLink ID | 54751 |
|---|---|
| 74202 | |
| 362650 |
| Alias | CAL |
|---|---|
| FBLP1 | |
| FBLP-1 | |
| DKFZp434G171 | |
| RP11-169K16.5 | |
| filamin-binding LIM protein 1 | |
| migfilin | |
| CSX-associated LIM | |
| OTTHUMP00000003118 | |
| OTTHUMP00000003120 | |
| MIG2-interacting protein | |
| filamin-binding LIM protein-1 | |
| mitogen-inducible 2 interacting protein | |
| mitogen-inducible 2-interacting protein | |
| Gt10 | |
| 2410043F08Rik | |
| RP23-291H3.1 | |
| OTTMUSP00000011062 | |
| OTTMUSP00000011063 | |
| MGC105665 | |
| 2410043F08 | |
| fblim1 | |
| FBLP I | |
| filamin-binding LIM protein I | |
| OTTHUMP00000003119 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607747 |
|---|
| Mouse chromosome position | 4 |
|---|
| GO ID | 0046872 |
|---|---|
| 0008270 | |
| 0007155 | |
| 0008360 | |
| 0005938 | |
| 0030054 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0005925 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | Q8WUP2 |
|---|---|
| Q5VVD3 | |
| Q5VVD6 | |
| Q3TDK3 | |
| Q71FD7 | |
| Q5U1Y3 | |
| B3KNY0 | |
| Q5VVE0 | |
| Q5VVE1 | |
| Q8IX23 | |
| Q96T00 | |
| Q9UFD6 | |
| Q99J35 |
| PIR ID | T42678 |
|---|
| Unigene ID | Hs.530101 |
|---|---|
| Mm.286536 | |
| Rn.2851 |
| KEGG ID | hsa:54751 |
|---|---|
| mmu:74202 | |
| rno:362650 |
| Swiss-Prot ID | FBLI1_HUMAN |
|---|---|
| FBLI1_MOUSE | |
| Q3TDK3_MOUSE | |
| Q5U1Y3_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| cell cortex | |
| Cell junction | |
| focal adhesion | |
| cytoskeleton | |
| Extracellular |
| IPI ID | IPI00290638 |
|---|---|
| IPI00291238 | |
| IPI00386562 | |
| IPI00114860 | |
| IPI00776395 | |
| IPI00567649 | |
| IPI00646795 | |
| IPI00647013 | |
| IPI00649806 | |
| IPI00647976 | |
| IPI00648253 | |
| IPI00648500 | |
| IPI00648789 | |
| IPI00648559 | |
| IPI00828755 | |
| IPI00649956 | |
| IPI00649699 | |
| IPI00359130 |
| Homologene ID | 56774 |
|---|
| RGD ID | 1359551 |
|---|
| MGI ID | 1921452 |
|---|