| URN | urn:agi-llid:8440 |
|---|---|
| Connectivity | 52 |
| Name | Nck2 |
| Description | non-catalytic region of tyrosine kinase adaptor protein 2 (predicted) |
| Notes | This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| Pathway | EphrinB -> JUN signaling |
|---|---|
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway |
| GO Molecular Function | cytoskeletal adaptor activity |
|---|---|
| receptor signaling complex scaffold activity | |
| kinase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| endoplasmic reticulum | |
| vesicle membrane |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| signal transduction | |
| regulation of epidermal growth factor receptor activity | |
| regulation of translation | |
| positive regulation of T cell proliferation | |
| positive regulation of actin filament polymerization | |
| T cell activation | |
| cell migration | |
| actin filament organization | |
| signal complex assembly | |
| lamellipodium assembly | |
| epidermal growth factor receptor signaling pathway |
| Group | negative regulation of cell proliferation |
|---|---|
| signal transduction | |
| regulation of epidermal growth factor receptor activity | |
| regulation of translation | |
| positive regulation of T cell proliferation | |
| positive regulation of actin filament polymerization | |
| T cell activation | |
| cell migration | |
| actin filament organization | |
| signal complex assembly | |
| lamellipodium assembly | |
| epidermal growth factor receptor signaling pathway | |
| cytoskeletal adaptor activity | |
| receptor signaling complex scaffold activity | |
| kinase activity | |
| cytoplasm | |
| endoplasmic reticulum | |
| vesicle membrane |
| MedScan ID | 8440 |
|---|
| Hugo ID | 7665 |
|---|
| Human chromosome position | 2q12 |
|---|
| LocusLink ID | 8440 |
|---|---|
| 17974 | |
| 316369 |
| Alias | GRB4 |
|---|---|
| NCKbeta | |
| cytoplasmic protein NCK2 | |
| SH2/SH3 adaptor protein NCK-beta | |
| noncatalytic region of tyrosine kinase, beta | |
| 4833426I10Rik | |
| non-catalytic region of tyrosine kinase adaptor protein 2 | |
| OTTMUSP00000023150 | |
| OTTMUSP00000023151 | |
| 4833426I10 | |
| AK014949 | |
| BC011071 | |
| BC034255 | |
| LOC115075 | |
| NCK adapter protein 2 | |
| NCK adapter protein II | |
| NCK adaptor protein 2 | |
| NCK adaptor protein II | |
| NCK2 | |
| NCK2 adapter protein | |
| NCK2 adaptor protein | |
| NM_010879 | |
| non-catalytic region of tyrosine kinase adapter protein 2 | |
| non-catalytic region of tyrosine kinase adapter protein II | |
| non-catalytic region of tyrosine kinase adaptor protein II | |
| SH2/SH3 adapter protein NCK-beta | |
| SH2/SH3 adaptor protein NCK-beta | |
| RIKEN cDNA 4833426I10 gene | |
| hypothetical gene supported by NM_010879, BC034255, AK014949, BC011071 | |
| non-catalytic region of tyrosine kinase adaptor protein 2 (predicted) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604930 |
|---|
| Mouse chromosome position | 1 |
|---|---|
| 1 C1 |
| GO ID | 0008093 |
|---|---|
| 0030159 | |
| 0042110 | |
| 0007015 | |
| 0016477 | |
| 0007173 | |
| 0030032 | |
| 0008285 | |
| 0042102 | |
| 0030838 | |
| 0007176 | |
| 0006417 | |
| 0007172 | |
| 0007165 | |
| 0005737 | |
| 0005783 | |
| 0012506 | |
| 0016301 | |
| 0005515 | |
| 0007242 |
| Rat chromosome position | 9q22 |
|---|
| Swiss-Prot Accession | O43639 |
|---|---|
| Q53T91 | |
| Q53TG4 | |
| O55033 | |
| Q8BQ28 | |
| Q78U92 | |
| Q9BWN9 | |
| Q9UIC3 | |
| D3DVK1 |
| Unigene ID | Hs.529244 |
|---|---|
| Mm.389903 | |
| Mm.476455 | |
| Rn.9067 | |
| Hs.707062 | |
| Mm.439923 | |
| Mm.233951 |
| KEGG ID | hsa:8440 |
|---|---|
| mmu:17974 | |
| rno:316369 |
| Swiss-Prot ID | NCK2_HUMAN |
|---|---|
| D3DVK1_HUMAN | |
| Q8BQ28_MOUSE | |
| O55033_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum | |
| Plasma membrane |
| IPI ID | IPI00306531 |
|---|---|
| IPI00309413 | |
| IPI00464976 | |
| IPI00108258 | |
| IPI00211891 |
| Homologene ID | 20794 |
|---|
| RGD ID | 1305965 |
|---|
| MGI ID | 1306821 |
|---|