| URN | urn:agi-llid:9270 |
|---|---|
| Connectivity | 45 |
| Name | Itgb1bp1 |
| Description | integrin beta 1 binding protein 1 |
| Notes | The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. [provided by RefSeq] |
| Pathway | FibronectinR -> ICAP-1A/MYC signaling |
|---|---|
| integrin mediated signaling pathway |
| GO Molecular Function | protein C-terminus binding |
|---|---|
| integrin binding |
| GO Cellular Component | membrane |
|---|---|
| ruffle | |
| lamellipodium | |
| cytoplasm | |
| cytosol |
| GO Biological Process | regulation of cell adhesion |
|---|---|
| intracellular protein kinase cascade | |
| cell migration | |
| cell-matrix adhesion | |
| integrin-mediated signaling pathway |
| Ariadne Ontology | ITG |
|---|
| Group | ITG |
|---|---|
| regulation of cell adhesion | |
| intracellular protein kinase cascade | |
| cell migration | |
| cell-matrix adhesion | |
| integrin-mediated signaling pathway | |
| protein C-terminus binding | |
| integrin binding | |
| membrane | |
| ruffle | |
| lamellipodium | |
| cytoplasm | |
| cytosol |
| MedScan ID | 9270 |
|---|
| Hugo ID | 23927 |
|---|
| Human chromosome position | 2p25.2 |
|---|
| LocusLink ID | 9270 |
|---|---|
| 16413 | |
| 298914 |
| Alias | ICAP1 |
|---|---|
| ICAP1A | |
| ICAP1B | |
| ICAP-1A | |
| ICAP-1B | |
| ICAP-1alpha | |
| DKFZp686K08158 | |
| integrin beta-1-binding protein 1 | |
| ICAP-1 | |
| bodenin | |
| OTTHUMP00000195586 | |
| OTTHUMP00000214081 | |
| OTTHUMP00000214084 | |
| OTTHUMP00000214085 | |
| OTTHUMP00000214088 | |
| integrin cytoplasmic domain-associated protein 1 | |
| integrin cytoplasmic domain-associated protein 1-beta | |
| integrin cytoplasmic domain-associated protein 1-alpha | |
| AI449260 | |
| AU019480 | |
| ITGB1BP1 | |
| Itgb1bp1_predicted | |
| bodenins | |
| ICAP I | |
| ICAP1alpha | |
| integrin beta 1 binding protein 1 | |
| integrin cytoplasmic domain-associated protein I | |
| ITGB1BP I | |
| LOC150980 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607153 |
|---|
| Mouse chromosome position | 12 |
|---|
| GO ID | 0016477 |
|---|---|
| 0007160 | |
| 0007243 | |
| 0005737 | |
| 0005829 | |
| 0030027 | |
| 0016020 | |
| 0001726 | |
| 0005178 | |
| 0008022 | |
| 0030155 | |
| 0007229 |
| Rat chromosome position | 6q16 |
|---|
| Swiss-Prot Accession | O14713 |
|---|---|
| Q53RS0 | |
| Q6IAZ8 | |
| O35671 | |
| Q3UGH2 | |
| B5DFL3 | |
| Q542A8 | |
| O14714 |
| Unigene ID | Hs.467662 |
|---|---|
| Mm.273333 | |
| Rn.29469 |
| KEGG ID | hsa:9270 |
|---|---|
| mmu:16413 | |
| rno:298914 |
| Swiss-Prot ID | ITBP1_MOUSE |
|---|---|
| ITBP1_HUMAN | |
| Q53RS0_HUMAN | |
| B5DFL3_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Plasma membrane |
| IPI ID | IPI00132866 |
|---|---|
| IPI00006265 | |
| IPI00219566 | |
| IPI00191226 | |
| IPI00853543 | |
| IPI00652430 |
| Homologene ID | 3496 |
|---|
| RGD ID | 1307810 |
|---|
| MGI ID | 1306802 |
|---|