| URN | urn:agi-llid:9345 |
|---|---|
| Connectivity | 37 |
| Name | Ilkap |
| Description | integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Notes | The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Pathway | integrin mediated signaling pathway |
|---|---|
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity |
| GO Cellular Component | protein serine-threonine phosphatase complex |
|---|---|
| cytoplasm |
| GO Biological Process | negative regulation of cell cycle |
|---|---|
| regulation of S phase of mitotic cell cycle | |
| protein amino acid dephosphorylation |
| Ariadne Ontology | Phosphatases |
|---|
| Group | Phosphatases |
|---|---|
| catalytic activity | |
| negative regulation of cell cycle | |
| regulation of S phase of mitotic cell cycle | |
| protein amino acid dephosphorylation | |
| hydrolase activity | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein serine-threonine phosphatase complex | |
| cytoplasm |
| MedScan ID | 9345 |
|---|
| Hugo ID | 15566 |
|---|
| Human chromosome position | 2q37.3 |
|---|
| LocusLink ID | 9345 |
|---|---|
| 80895 | |
| 67444 | |
| 64538 |
| Alias | MGC4846 |
|---|---|
| FLJ10181 | |
| PP2C-DELTA | |
| DKFZp434J2031 | |
| integrin-linked kinase-associated serine/threonine phosphatase 2C | |
| protein phosphatase 2c, delta isozyme | |
| 0710007A14Rik | |
| 1600009O09Rik | |
| PP2Cdelta | |
| protein phosphatase 2C | |
| 0710007A14 | |
| 1600009O09 | |
| AF095927 | |
| ILKAP | |
| integrin-linked kinase-associated phosphatase 2C | |
| Rattus norvegicus protein phosphatase 2C | |
| integrin-linked kinase-associated protein phosphatase 2C | |
| RIKEN cDNA 0710007A14 gene | |
| RIKEN cDNA 1600009O09 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 1 |
|---|---|
| 1 C5 |
| GO ID | 0016787 |
|---|---|
| 0046872 | |
| 0004722 | |
| 0045786 | |
| 0006470 | |
| 0007090 | |
| 0005737 | |
| 0008287 | |
| 0003824 | |
| 0004721 | |
| 0000287 | |
| 0030145 | |
| 0016301 | |
| 0007229 |
| Rat chromosome position | 9q36 |
|---|
| Swiss-Prot Accession | Q9H0C8 |
|---|---|
| Q8R0F6 | |
| Q9CS46 | |
| Q9Z0T2 | |
| Q9Z1Z6 | |
| Q05CC3 | |
| Q6P6U8 |
| Unigene ID | Hs.92033 |
|---|---|
| Mm.337240 | |
| Rn.6446 |
| KEGG ID | hsa:80895 |
|---|---|
| mmu:67444 | |
| rno:64538 |
| EC Number | 3.1.3.16 |
|---|
| Swiss-Prot ID | ILKAP_MOUSE |
|---|---|
| ILKAP_RAT | |
| ILKAP_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00396804 |
|---|---|
| IPI00828929 | |
| IPI00209353 | |
| IPI00006164 |
| Homologene ID | 31525 |
|---|
| RGD ID | 620128 |
|---|
| MGI ID | 1914694 |
|---|