| URN | urn:agi-llid:3987 |
|---|---|
| Connectivity | 80 |
| Name | Lims1 |
| Description | LIM and senescent cell antigen-like domains 1 |
| Notes | The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. [provided by RefSeq] |
| Pathway | integrin mediated signaling pathway |
|---|---|
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway |
| GO Molecular Function | protein domain specific binding |
|---|---|
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | protein complex |
|---|---|
| membrane | |
| plasma membrane | |
| cytosol | |
| cell junction | |
| focal adhesion |
| GO Biological Process | establishment or maintenance of cell polarity |
|---|---|
| cell aging | |
| chordate embryonic development | |
| cell-cell adhesion | |
| cell-matrix adhesion | |
| protein heterooligomerization |
| Ariadne Ontology | Focal junction assembly |
|---|
| Group | Focal junction assembly |
|---|---|
| establishment or maintenance of cell polarity | |
| cell aging | |
| chordate embryonic development | |
| cell-cell adhesion | |
| cell-matrix adhesion | |
| protein heterooligomerization | |
| protein domain specific binding | |
| metal ion binding | |
| zinc ion binding | |
| protein complex | |
| membrane | |
| plasma membrane | |
| cytosol | |
| cell junction | |
| focal adhesion |
| MedScan ID | 3987 |
|---|
| Hugo ID | 6616 |
|---|
| Human chromosome position | 2q12.3 |
|---|
| LocusLink ID | 3987 |
|---|---|
| 110829 | |
| 499443 |
| Alias | PINCH |
|---|---|
| PINCH1 | |
| LIM and senescent cell antigen-like-containing domain protein 1 | |
| PINCH-1 | |
| OTTHUMP00000203426 | |
| OTTHUMP00000203429 | |
| renal carcinoma antigen NY-REN-48 | |
| particularly interesting new Cys-His protein 1 | |
| Lims1l | |
| AI507642 | |
| AU021743 | |
| AW551584 | |
| 2310016J22Rik | |
| 4921524A02Rik | |
| C430041B13Rik | |
| OTTMUSP00000029919 | |
| OTTMUSP00000029921 | |
| LIM and senescent cell antigen-like domains 1-like | |
| RGD1560732 | |
| 2310016J22 | |
| 4921524A02 | |
| C430041B13 | |
| LIM and senescent cell antigen-like domains 1 | |
| LIM and senescent cell antigen-like domains I | |
| Lims I | |
| Lims1 | |
| LOC113680 | |
| MGC19129 | |
| OTTHUMP00000161608 | |
| Particularly interesting new Cys-His protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602567 |
|---|
| Mouse chromosome position | 10 30.0 cM |
|---|
| GO ID | 0046872 |
|---|---|
| 0008270 | |
| 0007569 | |
| 0030054 | |
| 0005829 | |
| 0005925 | |
| 0005886 | |
| 0016337 | |
| 0007160 | |
| 0043009 | |
| 0007163 | |
| 0051291 | |
| 0016020 | |
| 0043234 | |
| 0019904 | |
| 0005515 |
| Rat chromosome position | 20q11 |
|---|
| Swiss-Prot Accession | P48059 |
|---|---|
| Q99JW4 | |
| Q4ZJB3 | |
| Q9D7B2 | |
| C0KUC5 | |
| Q3UAT7 | |
| Q8BTR6 | |
| Q9D5T4 | |
| B2RAJ4 | |
| Q53TE0 | |
| Q9BS44 |
| PIR ID | JC2324 |
|---|
| Unigene ID | Hs.597715 |
|---|---|
| Hs.613268 | |
| Mm.57734 | |
| Mm.402697 | |
| Mm.443353 | |
| Rn.100399 |
| KEGG ID | hsa:3987 |
|---|---|
| mmu:110829 | |
| rno:499443 |
| Swiss-Prot ID | LIMS1_MOUSE |
|---|---|
| LIMS1_HUMAN | |
| C0KUC5_RAT |
| Cell Localization | Cell junction |
|---|---|
| focal adhesion | |
| Cell membrane | |
| Plasma membrane |
| IPI ID | IPI00108427 |
|---|---|
| IPI00788612 | |
| IPI00568559 | |
| IPI00872358 | |
| IPI00110120 | |
| IPI00858026 | |
| IPI00214561 |
| Homologene ID | 68428 |
|---|
| RGD ID | 1560732 |
|---|
| MGI ID | 1195263 |
|---|