| URN | urn:agi-llid:7094 |
|---|---|
| Connectivity | 191 |
| Name | Tln1 |
| Description | talin 1 |
| Notes | This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. |
| Pathway | integrin mediated signaling pathway |
|---|---|
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway |
| GO Molecular Function | structural molecule activity |
|---|---|
| structural constituent of cytoskeleton | |
| protein complex binding | |
| actin binding | |
| vinculin binding | |
| LIM domain binding | |
| insulin receptor binding | |
| integrin binding |
| GO Cellular Component | extracellular region |
|---|---|
| cell projection | |
| membrane | |
| plasma membrane | |
| ruffle | |
| cytoplasm | |
| intracellular membrane-bounded organelle | |
| cytosol | |
| centrosome | |
| cytoskeleton | |
| actin cytoskeleton | |
| ruffle membrane | |
| cell-cell junction | |
| focal adhesion |
| GO Biological Process | cell adhesion |
|---|---|
| cellular component movement | |
| muscle contraction | |
| cytoskeletal anchoring at plasma membrane | |
| cortical actin cytoskeleton organization | |
| cell-cell junction assembly | |
| cell-substrate junction assembly |
| Ariadne Ontology | Focal junction assembly |
|---|
| Group | Focal junction assembly |
|---|---|
| extracellular region | |
| structural molecule activity | |
| cell adhesion | |
| cellular component movement | |
| muscle contraction | |
| cytoskeletal anchoring at plasma membrane | |
| cortical actin cytoskeleton organization | |
| cell-cell junction assembly | |
| cell-substrate junction assembly | |
| structural constituent of cytoskeleton | |
| protein complex binding | |
| actin binding | |
| vinculin binding | |
| LIM domain binding | |
| insulin receptor binding | |
| integrin binding | |
| cell projection | |
| membrane | |
| plasma membrane | |
| ruffle | |
| cytoplasm | |
| intracellular membrane-bounded organelle | |
| cytosol | |
| centrosome | |
| cytoskeleton | |
| actin cytoskeleton | |
| ruffle membrane | |
| cell-cell junction | |
| focal adhesion |
| MedScan ID | 7094 |
|---|
| Hugo ID | 11845 |
|---|
| Human chromosome position | 9p13 |
|---|
| LocusLink ID | 7094 |
|---|---|
| 21894 | |
| 313494 |
| Alias | TLN |
|---|---|
| ILWEQ | |
| KIAA1027 | |
| RP11-112J3.1 | |
| talin-1 | |
| RP23-195K8.11 | |
| OTTMUSP00000007396 | |
| MGC116305 | |
| mKIAA1027 | |
| LOC313494 | |
| talin | |
| talin 1 | |
| talin I | |
| TLN I | |
| TLN1 | |
| talin 1s | |
| talin Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 186745 |
|---|
| Mouse chromosome position | 4 |
|---|---|
| 4 B1 |
| GO ID | 0030274 |
|---|---|
| 0003779 | |
| 0005158 | |
| 0005200 | |
| 0017166 | |
| 0007043 | |
| 0007044 | |
| 0006928 | |
| 0030866 | |
| 0007016 | |
| 0006936 | |
| 0005911 | |
| 0005813 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0005576 | |
| 0005925 | |
| 0043231 | |
| 0005886 | |
| 0001726 | |
| 0032587 | |
| 0005178 | |
| 0032403 | |
| 0005198 | |
| 0007155 | |
| 0015629 | |
| 0042995 | |
| 0016020 | |
| 0005515 | |
| 0005488 |
| Rat chromosome position | 5q22 |
|---|
| Swiss-Prot Accession | Q9Y490 |
|---|---|
| Q5TCU5 | |
| Q5TCU6 | |
| Q9H3E8 | |
| A2AIM8 | |
| Q0V930 | |
| Q3UHS6 | |
| Q80TM2 | |
| P26039 | |
| Q3TBC3 | |
| Q8C9Z8 | |
| Q3B7U7 | |
| Q498D4 | |
| A6NMY0 | |
| Q86YD0 | |
| Q9NZQ2 | |
| Q9UHH8 | |
| Q9UPX3 |
| Unigene ID | Hs.471014 |
|---|---|
| Mm.208601 | |
| Rn.7715 |
| KEGG ID | hsa:7094 |
|---|---|
| mmu:21894 | |
| rno:313494 |
| Swiss-Prot ID | TLN1_HUMAN |
|---|---|
| Q3UHS6_MOUSE | |
| Q0V930_MOUSE | |
| Q80TM2_MOUSE | |
| A2AIM8_MOUSE |
| Cell Localization | Cell projection |
|---|---|
| ruffle membrane | |
| Cytoplasm | |
| cytoskeleton | |
| Plasma membrane |
| IPI ID | IPI00298994 |
|---|---|
| IPI00929758 | |
| IPI00385946 | |
| IPI00642355 | |
| IPI00465786 | |
| IPI00648794 | |
| IPI00647984 | |
| IPI00648677 | |
| IPI00362014 |
| Homologene ID | 21267 |
|---|
| RGD ID | 1306247 |
|---|
| MGI ID | 1099832 |
|---|
| Source | Curated |
|---|