| URN | urn:agi-llid:3611 |
|---|---|
| Connectivity | 449 |
| Name | Ilk |
| Description | integrin linked kinase |
| Notes | serine/threonine kinase involved in intracellular signal transduction [RGD] |
| Pathway | integrin mediated signaling pathway |
|---|---|
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| nucleotide binding | |
| transferase activity | |
| protein domain specific binding | |
| SH3 domain binding | |
| integrin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity |
| GO Cellular Component | protein complex |
|---|---|
| membrane | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| dendritic shaft | |
| cytosol | |
| costamere | |
| stress fiber | |
| cell junction | |
| cell-cell junction | |
| focal adhesion | |
| terminal button | |
| axon |
| GO Biological Process | cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| cell aging | |
| myelin assembly | |
| positive regulation of axon extension | |
| positive regulation of dendrite morphogenesis | |
| positive regulation of axonogenesis | |
| positive regulation of myoblast differentiation | |
| substrate adhesion-dependent cell spreading | |
| neuron projection morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| regulation of cell growth | |
| cell cycle arrest | |
| regulation of signal transduction | |
| positive regulation of MAP kinase activity | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of MAPKKK cascade | |
| regulation of actin cytoskeleton organization | |
| negative regulation of protein kinase activity | |
| negative regulation of smooth muscle cell proliferation | |
| positive regulation of cell migration | |
| positive regulation of cell-matrix adhesion | |
| negative regulation of smooth muscle cell migration | |
| negative regulation of apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of cardiac muscle cell apoptosis | |
| cell-matrix adhesion | |
| establishment or maintenance of epithelial cell apical-basal polarity | |
| protein amino acid phosphorylation | |
| peptidyl-serine phosphorylation | |
| fibril organization | |
| protein heterooligomerization | |
| integrin-mediated signaling pathway |
| Ariadne Ontology | ILK |
|---|
| Group | ILK |
|---|---|
| cell proliferation | |
| positive regulation of cell proliferation | |
| cell aging | |
| myelin assembly | |
| positive regulation of axon extension | |
| positive regulation of dendrite morphogenesis | |
| positive regulation of axonogenesis | |
| positive regulation of myoblast differentiation | |
| substrate adhesion-dependent cell spreading | |
| neuron projection morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| regulation of cell growth | |
| cell cycle arrest | |
| regulation of signal transduction | |
| positive regulation of MAP kinase activity | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of MAPKKK cascade | |
| regulation of actin cytoskeleton organization | |
| negative regulation of protein kinase activity | |
| negative regulation of smooth muscle cell proliferation | |
| positive regulation of cell migration | |
| positive regulation of cell-matrix adhesion | |
| negative regulation of smooth muscle cell migration | |
| negative regulation of apoptosis | |
| negative regulation of neuron apoptosis | |
| negative regulation of cardiac muscle cell apoptosis | |
| cell-matrix adhesion | |
| establishment or maintenance of epithelial cell apical-basal polarity | |
| protein amino acid phosphorylation | |
| peptidyl-serine phosphorylation | |
| fibril organization | |
| protein heterooligomerization | |
| integrin-mediated signaling pathway | |
| signal transducer activity | |
| nucleotide binding | |
| transferase activity | |
| protein domain specific binding | |
| SH3 domain binding | |
| integrin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein complex | |
| membrane | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| dendritic shaft | |
| cytosol | |
| costamere | |
| stress fiber | |
| cell junction | |
| cell-cell junction | |
| focal adhesion | |
| terminal button | |
| axon |
| MedScan ID | 3611 |
|---|
| Hugo ID | 6040 |
|---|
| Human chromosome position | 11p15.5-p15.4 |
|---|
| LocusLink ID | 3611 |
|---|---|
| 16202 | |
| 170922 |
| Alias | P59 |
|---|---|
| ILK-2 | |
| DKFZp686F1765 | |
| integrin-linked protein kinase | |
| ILK-1 | |
| p59ILK | |
| integrin-linked kinase-2 | |
| 59 kDa serine/threonine-protein kinase | |
| ESTM24 | |
| AA511515 | |
| OTTMUSP00000031102 | |
| integrin binding protein kinase | |
| integrin linked kinase | |
| ILK2 | |
| 59 kDa serine/ threonine protein kinase | |
| ankyrin repeat containing serine-threonine protein kinase integrin-linked kinase | |
| EST AA511515 | |
| Ilk | |
| ILK I | |
| ILK II | |
| integrin-linked kinase | |
| integrin-linked kinase II | |
| Integrin-linked protein kinase 1 | |
| Integrin-linked protein kinase I | |
| P59 kinase | |
| ESTM24s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602366 |
|---|
| Mouse chromosome position | 7 |
|---|---|
| 7 E1 |
| GO ID | 0005524 |
|---|---|
| 0017124 | |
| 0005178 | |
| 0000166 | |
| 0004674 | |
| 0004871 | |
| 0016740 | |
| 0001658 | |
| 0007569 | |
| 0007050 | |
| 0008283 | |
| 0007160 | |
| 0045197 | |
| 0043206 | |
| 0007229 | |
| 0032288 | |
| 0010667 | |
| 0043524 | |
| 0006469 | |
| 0014912 | |
| 0048662 | |
| 0048812 | |
| 0018105 | |
| 0043406 | |
| 0043410 | |
| 0045773 | |
| 0030335 | |
| 0008284 | |
| 0001954 | |
| 0050775 | |
| 0045663 | |
| 0051897 | |
| 0006468 | |
| 0051291 | |
| 0032956 | |
| 0001558 | |
| 0009966 | |
| 0034446 | |
| 0030424 | |
| 0005911 | |
| 0043034 | |
| 0005737 | |
| 0005829 | |
| 0043198 | |
| 0005925 | |
| 0043025 | |
| 0005886 | |
| 0043234 | |
| 0001725 | |
| 0043195 | |
| 0016301 | |
| 0004672 | |
| 0043066 | |
| 0050772 | |
| 0030054 | |
| 0016020 | |
| 0019904 | |
| 0005515 | |
| 0004713 |
| Rat chromosome position | 1q33 |
|---|
| Swiss-Prot Accession | Q13418 |
|---|---|
| Q59FP4 | |
| O55222 | |
| Q99J82 | |
| P57043 | |
| Q68DZ3 | |
| Q78KK2 | |
| D3DQU0 |
| PIR ID | S68455 |
|---|
| Unigene ID | Hs.5158 |
|---|---|
| Hs.706355 | |
| Mm.274846 | |
| Rn.95042 | |
| Hs.708039 | |
| Hs.643525 |
| KEGG ID | hsa:3611 |
|---|---|
| mmu:16202 | |
| rno:170922 |
| EC Number | 2.7.11.1 |
|---|
| Swiss-Prot ID | ILK_HUMAN |
|---|---|
| ILK_RAT | |
| ILK_MOUSE | |
| D3DQU0_HUMAN |
| Cell Localization | Cell junction |
|---|---|
| focal adhesion | |
| Cell membrane | |
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00013219 |
|---|---|
| IPI00194728 | |
| IPI00116668 | |
| IPI00556543 | |
| IPI00857352 | |
| IPI00857189 |
| Homologene ID | 3318 |
|---|
| RGD ID | 620063 |
|---|
| MGI ID | 1195267 |
|---|
| Source | Curated |
|---|