Ariadne Genomics Inc. Itgb1bp1 ---- Krit1 Tln1 Itga Itga ---- Sharpin Fabp3 ---- Itga Fblim1 ---- filamins cell motility cell differentiation cell proliferation cell survival PIP2 Fblim1 ---| filamins kindlins (Fermt) Ilk Sharpin ---| Itgb Fabp3 Sharpin Fabp3 ---| Itgb Itgb Fblim1 Krit1 Itgb1bp1 ---| Itgb Itgb ---- Itgb1bp1 Itgb1bp1 filamins ---| Itgb filamins ---- Itgb Itgb ---> invasion Ptk2 RTK, others Itgb ---- Tln1 Itgb ---- Tln2 kindlins (Fermt) --+> Itgb Itgb ---- kindlins (Fermt) Itga ---> cell adhesion Itga ---> invasion invasion Ilk ---- Parvb Parva ---- Pxn Nck2 ---- RTK, others Ilk ---- Lims1 Ilk ---- Pxn Ilk ---- Parva Lims1 ---- Nck2 Ptk2 ---- RTK, others Ptk2 ---- Tln1 Ilk ---- Parvg Apbb1ip ---- Tln2 Apbb1ip ---- Tln1 Tln1 --+> Itgb Tln2 cell surface proteins Itgb ---> cell migration Itga ---> cell migration Itga ---> ECM assembly Itgb ---> ECM assembly RTK, others ---> invasion ECM assembly cell migration ECM proteins cell adhesion Itgb ---> cell adhesion Krit1 ---| Itgb1bp1 Tln2 --+> Itgb Pxn Ptk2 ---- Pxn Ilk ---- Lims2 Lims2 Lims1 Ilkap Ilkap ---| Ilk Parvb Parva Parvg Apbb1ip Nck2 Ilk ---- Itgb filamins