| URN | urn:agi-llid:53 |
|---|---|
| Connectivity | 8 |
| Name | Acp2 |
| Description | acid phosphatase 2, lysosomal |
| Notes | This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq] |
| Pathway | autophagy pathway |
|---|
| GO Molecular Function | hydrolase activity |
|---|---|
| phosphotyrosine binding | |
| acid phosphatase activity | |
| phosphoprotein phosphatase activity |
| GO Cellular Component | membrane |
|---|---|
| lysosomal lumen | |
| lysosomal membrane | |
| lysosome | |
| synaptosome | |
| integral to membrane |
| GO Biological Process | skeletal system development |
|---|---|
| synaptic transmission | |
| lysosome organization | |
| response to organic substance |
| Ariadne Ontology | Phosphatases |
|---|
| Group | Phosphatases |
|---|---|
| skeletal system development | |
| synaptic transmission | |
| lysosome organization | |
| response to organic substance | |
| hydrolase activity | |
| phosphotyrosine binding | |
| acid phosphatase activity | |
| phosphoprotein phosphatase activity | |
| membrane | |
| lysosomal lumen | |
| lysosomal membrane | |
| lysosome | |
| synaptosome | |
| integral to membrane |
| MedScan ID | 53 |
|---|
| Hugo ID | 123 |
|---|
| Human chromosome position | 11p11.2-p11.11 |
|---|
| LocusLink ID | 53 |
|---|---|
| 11432 | |
| 24162 |
| Alias | lysosomal acid phosphatase |
|---|---|
| LAP | |
| Acp-2 | |
| RP23-20F9.7 | |
| OTTMUSP00000015308 | |
| OTTMUSP00000044887 | |
| Acid phosphatase 2 lysozymal | |
| Acid phosphatase 2, lysozymal | |
| LMW-PTP-II low molecular weight phosphotyrosine protein phosphatase isozyme 2 | |
| acid phosphatase 2 | |
| acid phosphatase 2, lysosomal | |
| acid phosphatase II | |
| ACP2 | |
| LOC114969 | |
| LOC96117 | |
| lysosomal acid phosphatase 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 171650 |
|---|
| Mouse chromosome position | 2 52.0 cM |
|---|
| GO ID | 0003993 |
|---|---|
| 0016787 | |
| 0004721 | |
| 0001784 | |
| 0007040 | |
| 0010033 | |
| 0001501 | |
| 0016021 | |
| 0043202 | |
| 0005765 | |
| 0005764 | |
| 0016020 | |
| 0019717 | |
| 0007268 |
| Rat chromosome position | 3q24 |
|---|
| Swiss-Prot Accession | P11117 |
|---|---|
| A2AGR5 | |
| P24638 | |
| Q3U4F3 | |
| Q3UZN1 | |
| P20611 | |
| Q642D2 | |
| Q8QZT5 | |
| Q561W5 | |
| Q9BTU7 |
| PIR ID | A33395 |
|---|---|
| S14742 | |
| S06167 |
| Unigene ID | Hs.532492 |
|---|---|
| Mm.45570 | |
| Rn.9816 |
| KEGG ID | hsa:53 |
|---|---|
| mmu:11432 | |
| rno:24162 |
| EC Number | 3.1.3.2 |
|---|
| Swiss-Prot ID | PPAL_RAT |
|---|---|
| PPAL_MOUSE | |
| PPAL_HUMAN | |
| A2AGR5_MOUSE |
| Cell Localization | Lysosome membrane |
|---|---|
| Lysosome lumen | |
| Cytoplasm |
| IPI ID | IPI00201276 |
|---|---|
| IPI00154056 | |
| IPI00003807 | |
| IPI00909518 | |
| IPI00653175 | |
| IPI00777957 |
| Homologene ID | 1217 |
|---|
| RGD ID | 2021 |
|---|
| MGI ID | 87882 |
|---|