| URN | urn:agi-llid:9821 |
|---|---|
| Connectivity | 53 |
| Name | Rb1cc1 |
| Description | RB1-inducible coiled-coil 1 |
| Notes | The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq] |
| Pathway | autophagy pathway |
|---|
| GO Cellular Component | cytoplasm |
|---|---|
| pre-autophagosomal structure | |
| cytosol | |
| ULK1-ATG13-FIP200 complex | |
| nucleus |
| GO Biological Process | cell cycle |
|---|---|
| heart development | |
| liver development | |
| JNK cascade | |
| regulation of transcription | |
| positive regulation of protein amino acid phosphorylation | |
| negative regulation of apoptosis | |
| autophagy | |
| transcription | |
| autophagic vacuole assembly | |
| positive regulation of cell size |
| Group | cell cycle |
|---|---|
| heart development | |
| liver development | |
| JNK cascade | |
| regulation of transcription | |
| positive regulation of protein amino acid phosphorylation | |
| negative regulation of apoptosis | |
| autophagy | |
| transcription | |
| autophagic vacuole assembly | |
| positive regulation of cell size | |
| cytoplasm | |
| pre-autophagosomal structure | |
| cytosol | |
| ULK1-ATG13-FIP200 complex | |
| nucleus |
| MedScan ID | 9821 |
|---|
| Hugo ID | 15574 |
|---|
| Human chromosome position | 8q11 |
|---|
| LocusLink ID | 9821 |
|---|---|
| 12421 | |
| 312927 |
| Alias | CC1 |
|---|---|
| FIP200 | |
| RB1-inducible coiled-coil protein 1 | |
| 200 kDa FAK family kinase-interacting protein | |
| LaXp180 | |
| 2900055E04Rik | |
| 5930404L04Rik | |
| coiled coil forming protein 1 | |
| coiled-coil-forming protein 1 | |
| RBICC | |
| Kiaa0203 | |
| 200 kda fak family kinase-interacting protein fip200 | |
| 2900055E04 | |
| 5930404L04 | |
| cc1 protein | |
| coiled coil forming protein I | |
| DRAGOU14 | |
| likely ortholog of coiled coil forming protein 1 | |
| likely ortholog of coiled coil forming protein I | |
| likely ortholog of mouse coiled coil forming protein 1 | |
| likely ortholog of mouse coiled coil forming protein I | |
| mKIAA0203 | |
| RB1CC I | |
| RB1CC1 | |
| Rb1-inducible coiled coil protein 1 | |
| Rb1-inducible coiled coil protein I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606837 |
|---|---|
| 114480 |
| Mouse chromosome position | 1 |
|---|
| GO ID | 0007254 |
|---|---|
| 0000045 | |
| 0006914 | |
| 0007049 | |
| 0007507 | |
| 0001889 | |
| 0043066 | |
| 0045793 | |
| 0001934 | |
| 0045449 | |
| 0070969 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0000407 | |
| 0006350 |
| Rat chromosome position | 5q12 |
|---|
| Swiss-Prot Accession | Q8TDY2 |
|---|---|
| Q86YR4 | |
| Q9ESK9 | |
| Q6NZG0 | |
| Q8BT47 | |
| Q8CHH8 | |
| Q8WVU9 | |
| Q92601 | |
| Q3TXX2 | |
| Q61384 | |
| Q8BRY9 | |
| Q9JK14 |
| PIR ID | I48282 |
|---|
| Unigene ID | Hs.196102 |
|---|---|
| Mm.293811 | |
| Rn.33137 |
| KEGG ID | hsa:9821 |
|---|---|
| mmu:12421 | |
| rno:312927 |
| Swiss-Prot ID | RBCC1_HUMAN |
|---|---|
| RBCC1_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| cytosol | |
| Preautophagosomal structure |
| IPI ID | IPI00783392 |
|---|---|
| IPI00113372 | |
| IPI00794069 | |
| IPI00458733 | |
| IPI00366588 |
| Homologene ID | 7659 |
|---|
| RGD ID | 1309346 |
|---|
| MGI ID | 1341850 |
|---|