| URN | urn:agi-llid:8408 |
|---|---|
| Connectivity | 83 |
| Name | Ulk1 |
| Description | unc-51-like kinase 1 (C. elegans) |
| Notes | predicted to have similarity to C. elegans serine/threonine kinase UNC-51 [RGD] |
| Pathway | autophagy pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| protein complex binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity |
| GO Cellular Component | neuron projection |
|---|---|
| neuronal cell body | |
| cytoplasm | |
| pre-autophagosomal structure | |
| cytosol | |
| ULK1-ATG13-FIP200 complex | |
| autophagic vacuole | |
| cytoplasmic vesicle membrane | |
| membrane fraction |
| GO Biological Process | negative regulation of collateral sprouting |
|---|---|
| axon extension | |
| neuron projection regeneration | |
| axonogenesis | |
| cerebellar granule cell differentiation | |
| signal transduction | |
| neuron projection development | |
| Ras protein signal transduction | |
| regulation of autophagy | |
| receptor internalization | |
| radial glia guided migration of granule cell | |
| autophagy | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| autophagic vacuole assembly | |
| regulation of nerve growth factor receptor signaling pathway | |
| protein localization |
| Group | negative regulation of collateral sprouting |
|---|---|
| axon extension | |
| neuron projection regeneration | |
| axonogenesis | |
| cerebellar granule cell differentiation | |
| signal transduction | |
| neuron projection development | |
| Ras protein signal transduction | |
| regulation of autophagy | |
| receptor internalization | |
| radial glia guided migration of granule cell | |
| autophagy | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| autophagic vacuole assembly | |
| regulation of nerve growth factor receptor signaling pathway | |
| protein localization | |
| nucleotide binding | |
| transferase activity | |
| protein complex binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| neuron projection | |
| neuronal cell body | |
| cytoplasm | |
| pre-autophagosomal structure | |
| cytosol | |
| ULK1-ATG13-FIP200 complex | |
| autophagic vacuole | |
| cytoplasmic vesicle membrane | |
| membrane fraction |
| MedScan ID | 8408 |
|---|
| Hugo ID | 12558 |
|---|
| Human chromosome position | 12q24.3 |
|---|
| LocusLink ID | 8408 |
|---|---|
| 22241 | |
| 360827 |
| Alias | ATG1 |
|---|---|
| ATG1A | |
| UNC51 | |
| Unc51.1 | |
| FLJ38455 | |
| FLJ46475 | |
| serine/threonine-protein kinase ULK1 | |
| ATG1 autophagy related 1 homolog | |
| AU041434 | |
| mKIAA0722 | |
| unc-51-like kinase 1 | |
| serine/threonine-protein kinase Unc51.1 | |
| KIAA0722 | |
| LOC288726 | |
| Serine/threonine-protein kinase ULK I | |
| Ulk I | |
| Ulk1 | |
| unc-51 (C. elegans)-like kinase 1 | |
| unc-51 (C. elegans)-like kinase I | |
| Unc-51 like kinase 1 | |
| Unc-51 like kinase 1 (C. elegans) | |
| unc-51 -like kinase I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603168 |
|---|
| Mouse chromosome position | 5 |
|---|
| GO ID | 0005524 |
|---|---|
| 0000166 | |
| 0032403 | |
| 0004674 | |
| 0016740 | |
| 0007265 | |
| 0048675 | |
| 0021707 | |
| 0048671 | |
| 0031175 | |
| 0046777 | |
| 0006468 | |
| 0008104 | |
| 0021933 | |
| 0031623 | |
| 0010506 | |
| 0051386 | |
| 0007165 | |
| 0070969 | |
| 0005776 | |
| 0005737 | |
| 0030659 | |
| 0005829 | |
| 0005624 | |
| 0043005 | |
| 0043025 | |
| 0000407 | |
| 0016301 | |
| 0004672 | |
| 0006914 | |
| 0007409 | |
| 0031102 | |
| 0000045 |
| Rat chromosome position | 12q16 |
|---|
| Swiss-Prot Accession | O75385 |
|---|---|
| O70405 | |
| Q3U0V5 | |
| Q3U350 | |
| Q3UFT4 | |
| Q6PB82 | |
| Q80TT3 | |
| Q8K0Q7 | |
| Q9UQ28 | |
| Q6PGB2 |
| PIR ID | JW0051 |
|---|
| Unigene ID | Hs.47061 |
|---|---|
| Mm.271898 | |
| Rn.24509 |
| KEGG ID | hsa:8408 |
|---|---|
| mmu:22241 | |
| rno:360827 |
| EC Number | 2.7.11.1 |
|---|
| Swiss-Prot ID | ULK1_HUMAN |
|---|---|
| ULK1_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| cytosol | |
| Preautophagosomal structure |
| IPI ID | IPI00289357 |
|---|---|
| IPI00752067 | |
| IPI00384800 | |
| IPI00792161 | |
| IPI00467843 | |
| IPI00869638 |
| Homologene ID | 2640 |
|---|
| RGD ID | 1589743 |
|---|
| MGI ID | 1270126 |
|---|