Ariadne Genomics Inc. Lamp members SNARE, ESCRT, Rabs Atg4 members Atg9 members LC3 conjugation system Atg12 conjugation system Pik3c3 Pik3r4 Atg14 Rb1cc1 Ulk1 mTOR signaling pathway PtdIns3P Atg4 members ---> LC3 conjugation system starvation ---| mTOR signaling pathway nutrient-rich --+> mTOR signaling pathway starvation nutrient-rich Becn1 ---- Uvrag Ulk2 --+> Atg13 Ulk1 --+> Rb1cc1 Becn1 class III PI3K complex Becn1 ---- Rubicon mTOR signaling pathway ---| Ulk1 mTOR signaling pathway ---| Ulk2 Rubicon Uvrag Atg12 conjugation system ---> LC3 conjugation system Acp2 ---> degradation Acp2 degradation Lamp members ---> degradation Ulk2 Atg13 Atg13 ---- Rb1cc1 Pik3c3 ---> PtdIns3P PE Ulk/Atg13/Atg17 complex class III PI3K complex ---> Atg12 conjugation system