| URN | urn:agi-llid:183 |
|---|---|
| Connectivity | 2483 |
| Name | Agt |
| Description | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| Notes | The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq] |
| Pathway | AngiotensinR -> CREB/ELK-SRF/TP53 signaling |
|---|---|
| AngiotensinR -> STAT signaling | |
| renin-angiotensin system signaling pathway | |
| angiotensin II signaling pathway | |
| angiotensin II signaling pathway via AT1 receptor |
| GO Molecular Function | hormone activity |
|---|---|
| growth factor activity | |
| angiotensin receptor binding | |
| type 1 angiotensin receptor binding | |
| type 2 angiotensin receptor binding | |
| acetyltransferase activator activity | |
| serine-type endopeptidase inhibitor activity | |
| alpha1-adrenergic receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| soluble fraction | |
| cytoplasmic part |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| regulation of cell proliferation | |
| hormone metabolic process | |
| cell-cell signaling | |
| blood vessel development | |
| kidney development | |
| smooth muscle cell differentiation | |
| establishment of blood-nerve barrier | |
| positive regulation of macrophage derived foam cell differentiation | |
| branching involved in ureteric bud morphogenesis | |
| positive regulation of multicellular organism growth | |
| positive regulation of cytokine production | |
| blood vessel remodeling | |
| excretion | |
| positive regulation of cardiac muscle hypertrophy | |
| regulation of vasoconstriction | |
| regulation of natriuresis | |
| regulation of long-term neuronal synaptic plasticity | |
| natriuresis | |
| renin-angiotensin regulation of aldosterone production | |
| renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure | |
| brain renin-angiotensin system | |
| regulation of blood volume by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| peristalsis | |
| regulation of blood vessel size | |
| vasoconstriction | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| astrocyte activation | |
| regulation of cell growth | |
| negative regulation of cell growth | |
| extracellular matrix organization | |
| oxygen and reactive oxygen species metabolic process | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| positive regulation of MAPKKK cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| positive regulation of cholesterol esterification | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of fatty acid biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of fibroblast proliferation | |
| positive regulation of endothelial cell migration | |
| positive regulation of apoptosis | |
| negative regulation of neuron apoptosis | |
| regulation of norepinephrine secretion | |
| cell-matrix adhesion | |
| cellular sodium ion homeostasis | |
| smooth muscle cell proliferation | |
| response to muscle activity involved in regulation of muscle adaptation | |
| response to cold | |
| response to salt stress | |
| positive regulation of inflammatory response | |
| drinking behavior | |
| positive regulation of organ growth | |
| low-density lipoprotein particle remodeling | |
| cell surface receptor linked signaling pathway | |
| nitric oxide mediated signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| ovarian follicle rupture | |
| regulation of blood pressure | |
| positive regulation of catalytic activity | |
| positive regulation of NAD(P)H oxidase activity | |
| activation of phospholipase C activity |
| Ariadne Ontology | Neuromodulator |
|---|
| Group | Neuromodulator |
|---|---|
| extracellular region | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| hormone metabolic process | |
| cell-cell signaling | |
| blood vessel development | |
| kidney development | |
| smooth muscle cell differentiation | |
| establishment of blood-nerve barrier | |
| positive regulation of macrophage derived foam cell differentiation | |
| branching involved in ureteric bud morphogenesis | |
| positive regulation of multicellular organism growth | |
| positive regulation of cytokine production | |
| blood vessel remodeling | |
| excretion | |
| positive regulation of cardiac muscle hypertrophy | |
| regulation of vasoconstriction | |
| regulation of natriuresis | |
| regulation of long-term neuronal synaptic plasticity | |
| natriuresis | |
| renin-angiotensin regulation of aldosterone production | |
| renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure | |
| brain renin-angiotensin system | |
| regulation of blood volume by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| peristalsis | |
| regulation of blood vessel size | |
| vasoconstriction | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| astrocyte activation | |
| regulation of cell growth | |
| negative regulation of cell growth | |
| extracellular matrix organization | |
| oxygen and reactive oxygen species metabolic process | |
| positive regulation of phosphoinositide 3-kinase cascade | |
| positive regulation of MAPKKK cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| positive regulation of cholesterol esterification | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of fatty acid biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of fibroblast proliferation | |
| positive regulation of endothelial cell migration | |
| positive regulation of apoptosis | |
| negative regulation of neuron apoptosis | |
| regulation of norepinephrine secretion | |
| cell-matrix adhesion | |
| cellular sodium ion homeostasis | |
| smooth muscle cell proliferation | |
| response to muscle activity involved in regulation of muscle adaptation | |
| response to cold | |
| response to salt stress | |
| positive regulation of inflammatory response | |
| drinking behavior | |
| positive regulation of organ growth | |
| low-density lipoprotein particle remodeling | |
| cell surface receptor linked signaling pathway | |
| nitric oxide mediated signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| ovarian follicle rupture | |
| regulation of blood pressure | |
| positive regulation of catalytic activity | |
| positive regulation of NAD(P)H oxidase activity | |
| activation of phospholipase C activity | |
| hormone activity | |
| growth factor activity | |
| angiotensin receptor binding | |
| type 1 angiotensin receptor binding | |
| type 2 angiotensin receptor binding | |
| acetyltransferase activator activity | |
| serine-type endopeptidase inhibitor activity | |
| alpha1-adrenergic receptor activity | |
| extracellular space | |
| soluble fraction | |
| cytoplasmic part |
| MedScan ID | 183 |
|---|
| Hugo ID | 333 |
|---|
| Human chromosome position | 1q42-q43 |
|---|
| LocusLink ID | 183 |
|---|---|
| 11606 | |
| 24179 |
| Alias | ANHU |
|---|---|
| FLJ92595 | |
| FLJ97926 | |
| SERPINA8 | |
| angiotensinogen | |
| serpin A8 | |
| angiotensin I | |
| angiotensin II | |
| pre-angiotensinogen | |
| alpha-1 antiproteinase, antitrypsin | |
| serine (or cysteine) proteinase inhibitor | |
| AngII | |
| Aogen | |
| AI265500 | |
| angiotensin ll | |
| Ang | |
| PAT | |
| ANRT | |
| MGC105326 | |
| angiotensinogen (PAT) | |
| ANG I | |
| ANG II | |
| angiotensin | |
| angiotensin II human | |
| angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha- | |
| angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | |
| Human angiotensin II | |
| OTTHUMP00000035878 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 106150 |
|---|---|
| 145500 | |
| 267430 |
| Mouse chromosome position | 8 68.0 cM |
|---|
| GO ID | 0010698 |
|---|---|
| 0008083 | |
| 0005179 | |
| 0004867 | |
| 0031702 | |
| 0031703 | |
| 0007186 | |
| 0007199 | |
| 0007200 | |
| 0001998 | |
| 0048143 | |
| 0001568 | |
| 0001974 | |
| 0002035 | |
| 0001658 | |
| 0007267 | |
| 0007160 | |
| 0006883 | |
| 0042756 | |
| 0008065 | |
| 0030198 | |
| 0042445 | |
| 0001822 | |
| 0034374 | |
| 0030308 | |
| 0008285 | |
| 0051387 | |
| 0043524 | |
| 0007263 | |
| 0001543 | |
| 0006800 | |
| 0030432 | |
| 0043410 | |
| 0033864 | |
| 0051092 | |
| 0043065 | |
| 0010613 | |
| 0043085 | |
| 0032270 | |
| 0010873 | |
| 0001819 | |
| 0010595 | |
| 0045742 | |
| 0045723 | |
| 0048146 | |
| 0050729 | |
| 0010744 | |
| 0040018 | |
| 0046622 | |
| 0050731 | |
| 0014068 | |
| 0008217 | |
| 0002034 | |
| 0002016 | |
| 0001558 | |
| 0042127 | |
| 0048169 | |
| 0003078 | |
| 0014061 | |
| 0002019 | |
| 0019229 | |
| 0001999 | |
| 0002018 | |
| 0009409 | |
| 0014873 | |
| 0009651 | |
| 0051145 | |
| 0048659 | |
| 0044444 | |
| 0005576 | |
| 0005615 | |
| 0005625 | |
| 0031701 | |
| 0007202 | |
| 0007166 | |
| 0007588 | |
| 0030147 | |
| 0050880 | |
| 0001991 | |
| 0042310 | |
| 0004937 |
| Rat chromosome position | 19q12 |
|---|
| Swiss-Prot Accession | B0ZBE2 |
|---|---|
| B2R5S1 | |
| P01019 | |
| Q53GY3 | |
| Q53YY1 | |
| Q59EP2 | |
| Q86U78 | |
| Q3UTR7 | |
| P11859 | |
| Q8VCN0 | |
| P01015 | |
| Q16358 | |
| Q16359 | |
| Q96F91 |
| PIR ID | A93945 |
|---|---|
| A35203 |
| Unigene ID | Hs.19383 |
|---|---|
| Mm.301626 | |
| Rn.6319 |
| KEGG ID | hsa:183 |
|---|---|
| mmu:11606 | |
| rno:24179 |
| Swiss-Prot ID | ANGT_RAT |
|---|---|
| ANGT_HUMAN | |
| Q3UTR7_MOUSE | |
| B0ZBE2_HUMAN | |
| B2R5S1_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00209744 |
|---|---|
| IPI00032220 | |
| IPI00654069 |
| Homologene ID | 14 |
|---|
| RGD ID | 2069 |
|---|
| MGI ID | 87963 |
|---|