| URN | urn:agi-llid:186 |
|---|---|
| Connectivity | 485 |
| Name | Agtr2 |
| Description | angiotensin II receptor, type 2 |
| Notes | The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq] |
| Pathway | AngiotensinR -> CREB/ELK-SRF/TP53 signaling |
|---|---|
| AngiotensinR -> STAT signaling | |
| renin-angiotensin system signaling pathway | |
| angiotensin II signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| transcription factor binding | |
| G-protein alpha-subunit binding | |
| peptide hormone binding | |
| receptor antagonist activity | |
| angiotensin type II receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| perinuclear region of cytoplasm | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | behavior |
|---|---|
| positive regulation of branching involved in ureteric bud morphogenesis | |
| brain development | |
| neuron differentiation | |
| positive regulation of vasodilation | |
| blood vessel remodeling | |
| negative regulation of heart rate | |
| natriuresis | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| vasodilation by angiotensin involved in regulation of systemic arterial blood pressure | |
| signal transduction | |
| negative regulation of cell growth | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| intracellular protein kinase cascade | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of phosphoprotein phosphatase activity | |
| positive regulation of apoptosis | |
| negative regulation of blood vessel endothelial cell migration | |
| negative regulation of neuron apoptosis | |
| regulation of transcription factor import into nucleus | |
| cellular sodium ion homeostasis | |
| cellular response to dexamethasone stimulus | |
| response to organic nitrogen | |
| negative regulation of icosanoid secretion | |
| cell surface receptor linked signaling pathway | |
| nitric oxide mediated signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| regulation of blood pressure | |
| positive regulation of nitric-oxide synthase activity |
| Ariadne Ontology | GPCR-GiCR |
|---|
| Group | GPCR-GiCR |
|---|---|
| behavior | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| brain development | |
| neuron differentiation | |
| positive regulation of vasodilation | |
| blood vessel remodeling | |
| negative regulation of heart rate | |
| natriuresis | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| vasodilation by angiotensin involved in regulation of systemic arterial blood pressure | |
| signal transduction | |
| negative regulation of cell growth | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| intracellular protein kinase cascade | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of phosphoprotein phosphatase activity | |
| positive regulation of apoptosis | |
| negative regulation of blood vessel endothelial cell migration | |
| negative regulation of neuron apoptosis | |
| regulation of transcription factor import into nucleus | |
| cellular sodium ion homeostasis | |
| cellular response to dexamethasone stimulus | |
| response to organic nitrogen | |
| negative regulation of icosanoid secretion | |
| cell surface receptor linked signaling pathway | |
| nitric oxide mediated signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| regulation of blood pressure | |
| positive regulation of nitric-oxide synthase activity | |
| signal transducer activity | |
| transcription factor binding | |
| G-protein alpha-subunit binding | |
| peptide hormone binding | |
| receptor antagonist activity | |
| angiotensin type II receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| membrane | |
| plasma membrane | |
| perinuclear region of cytoplasm | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 186 |
|---|
| Hugo ID | 338 |
|---|
| Human chromosome position | Xq22-q23 |
|---|
| LocusLink ID | 186 |
|---|---|
| 11609 | |
| 24182 |
| Alias | AT2 |
|---|---|
| ATGR2 | |
| MRX88 | |
| type-2 angiotensin II receptor | |
| angiotensin II type-2 receptor | |
| AI316812 | |
| AW107640 | |
| RP23-368N20.1 | |
| AT2 receptor | |
| OTTMUSP00000018718 | |
| AT2R | |
| AT2-R | |
| AT<sub>2</sub>R | |
| angiotensin receptor 2 | |
| angiotensin II type 2 receptor | |
| AGTR2 | |
| ANG type 2 receptor | |
| angiotensin AT(2)-receptor | |
| angiotensin AT(2)-receptors | |
| angiotensin II receptor, type 2 | |
| angiotensin II receptor, type II | |
| Angiotensin receptor II | |
| angiotensin type 2 receptor | |
| AT sub2 /sub R | |
| AT(2) | |
| AT2 receptors | |
| OTTHUMP00000023878 | |
| Type-2 angiotensin II receptors |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300034 |
|---|
| Mouse chromosome position | X 12.5 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0004945 | |
| 0004872 | |
| 0048019 | |
| 0007186 | |
| 0007199 | |
| 0007610 | |
| 0001974 | |
| 0007420 | |
| 0002035 | |
| 0007166 | |
| 0007243 | |
| 0043537 | |
| 0030308 | |
| 0010459 | |
| 0051387 | |
| 0007263 | |
| 0043065 | |
| 0045429 | |
| 0051000 | |
| 0032516 | |
| 0045909 | |
| 0008217 | |
| 0001991 | |
| 0002033 | |
| 0005887 | |
| 0005886 | |
| 0017046 | |
| 0004871 | |
| 0008134 | |
| 0071549 | |
| 0006883 | |
| 0030147 | |
| 0043524 | |
| 0090190 | |
| 0042990 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0048471 | |
| 0001965 | |
| 0032304 | |
| 0030182 | |
| 0010243 |
| Rat chromosome position | Xq34 |
|---|
| Swiss-Prot Accession | P50052 |
|---|---|
| Q6UVH2 | |
| A2AUT5 | |
| P35374 | |
| Q3US12 | |
| B1WBL8 | |
| P35351 | |
| B2R9V1 | |
| Q13016 | |
| Q6FGY7 |
| PIR ID | JC2543 |
|---|---|
| A49092 | |
| I48261 |
| Unigene ID | Hs.405348 |
|---|---|
| Mm.2679 | |
| Rn.162367 |
| KEGG ID | hsa:186 |
|---|---|
| mmu:11609 | |
| rno:24182 |
| Swiss-Prot ID | AGTR2_HUMAN |
|---|---|
| AGTR2_RAT | |
| AGTR2_MOUSE | |
| B1WBL8_RAT | |
| A2AUT5_MOUSE | |
| B2R9V1_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00029486 |
|---|---|
| IPI00197641 | |
| IPI00117520 |
| Homologene ID | 20172 |
|---|
| RGD ID | 2072 |
|---|
| MGI ID | 87966 |
|---|