| URN | urn:agi-llid:185 |
|---|---|
| Connectivity | 1129 |
| Name | Agtr1a |
| Description | angiotensin II receptor, type 1 |
| Notes | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq] |
| Pathway | AngiotensinR -> CREB/ELK-SRF/TP53 signaling |
|---|---|
| AngiotensinR -> STAT signaling | |
| renin-angiotensin system signaling pathway | |
| angiotensin II signaling pathway | |
| angiotensin II signaling pathway via AT1 receptor |
| GO Molecular Function | signal transducer activity |
|---|---|
| protein self-association | |
| G-protein alpha-subunit binding | |
| peptide hormone binding | |
| protein heterodimerization activity | |
| bradykinin receptor binding | |
| C-X-C chemokine receptor activity | |
| bradykinin receptor activity | |
| angiotensin type II receptor activity | |
| angiotensin type I receptor activity | |
| acetyltransferase activator activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | endomembrane system |
|---|---|
| membrane | |
| plasma membrane | |
| cytoplasm | |
| organelle outer membrane | |
| cytoplasmic vesicle | |
| endosome | |
| Golgi apparatus | |
| basolateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| dendrite | |
| vesicle membrane | |
| vesicle lumen |
| GO Biological Process | regulation of cell proliferation |
|---|---|
| positive regulation of branching involved in ureteric bud morphogenesis | |
| blood vessel development | |
| kidney development | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of cytokine secretion | |
| regulation of vasoconstriction | |
| regulation of vasodilation | |
| regulation of natriuresis | |
| renin-angiotensin regulation of aldosterone production | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| signal transduction | |
| regulation of cell growth | |
| oxygen and reactive oxygen species metabolic process | |
| calcium-mediated signaling | |
| Rho protein signal transduction | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| positive regulation of cholesterol esterification | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of receptor recycling | |
| negative regulation of neuron apoptosis | |
| renin secretion into blood stream | |
| cell chemotaxis | |
| elevation of cytosolic calcium ion concentration | |
| elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger | |
| cellular response to dexamethasone stimulus | |
| response to estrogen stimulus | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| drinking behavior | |
| low-density lipoprotein particle remodeling | |
| G-protein coupled receptor protein signaling pathway | |
| regulation of blood pressure | |
| positive regulation of blood pressure | |
| regulation of pH | |
| positive regulation of NAD(P)H oxidase activity | |
| positive regulation of phospholipase A2 activity |
| Ariadne Ontology | GPCR-G12CR |
|---|
| Group | GPCR-G12CR |
|---|---|
| regulation of cell proliferation | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| blood vessel development | |
| kidney development | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of cytokine secretion | |
| regulation of vasoconstriction | |
| regulation of vasodilation | |
| regulation of natriuresis | |
| renin-angiotensin regulation of aldosterone production | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| signal transduction | |
| regulation of cell growth | |
| oxygen and reactive oxygen species metabolic process | |
| calcium-mediated signaling | |
| Rho protein signal transduction | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| positive regulation of cholesterol esterification | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of receptor recycling | |
| negative regulation of neuron apoptosis | |
| renin secretion into blood stream | |
| cell chemotaxis | |
| elevation of cytosolic calcium ion concentration | |
| elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger | |
| cellular response to dexamethasone stimulus | |
| response to estrogen stimulus | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| drinking behavior | |
| low-density lipoprotein particle remodeling | |
| G-protein coupled receptor protein signaling pathway | |
| regulation of blood pressure | |
| positive regulation of blood pressure | |
| regulation of pH | |
| positive regulation of NAD(P)H oxidase activity | |
| positive regulation of phospholipase A2 activity | |
| signal transducer activity | |
| protein self-association | |
| G-protein alpha-subunit binding | |
| peptide hormone binding | |
| protein heterodimerization activity | |
| bradykinin receptor binding | |
| C-X-C chemokine receptor activity | |
| bradykinin receptor activity | |
| angiotensin type II receptor activity | |
| angiotensin type I receptor activity | |
| acetyltransferase activator activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| endomembrane system | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| organelle outer membrane | |
| cytoplasmic vesicle | |
| endosome | |
| Golgi apparatus | |
| basolateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| dendrite | |
| vesicle membrane | |
| vesicle lumen |
| MedScan ID | 185 |
|---|
| Hugo ID | 336 |
|---|
| Human chromosome position | 3q21-q25 |
|---|
| LocusLink ID | 185 |
|---|---|
| 11607 | |
| 24180 |
| Alias | AT1 |
|---|---|
| AG2S | |
| AT1B | |
| AT1R | |
| AT2R1 | |
| HAT1R | |
| AGTR1A | |
| AGTR1B | |
| AT2R1A | |
| AT2R1B | |
| type-1 angiotensin II receptor | |
| AT1AR | |
| AT1BR | |
| angiotensin receptor 1 | |
| angiotensin receptor 1B | |
| angiotensin II type-1 receptor | |
| type-1B angiotensin II receptor | |
| AT1a | |
| Agtr1 | |
| Agtr-1a | |
| AI551199 | |
| Angtr-1a | |
| MGC37610 | |
| 1810074K20Rik | |
| type-1A angiotensin II receptor | |
| OTTMUSP00000000614 | |
| angiotensin receptor 1a | |
| angiotensin II type-1A receptor | |
| vascular type-1 angiotensin II receptor | |
| 1810074K20 | |
| AGTR I | |
| ANG type 1 receptor | |
| angiotensin AT(1)-receptor | |
| angiotensin AT(1)-receptors | |
| angiotensin II receptor, type 1 | |
| angiotensin II receptor, type 1a | |
| angiotensin II receptor, type 1b | |
| angiotensin II receptor, type I | |
| angiotensin II type-1 receptors | |
| angiotensin receptor I | |
| angiotensin type 1 receptor | |
| Angtr-1b | |
| AT(1) | |
| AT1 receptor | |
| AT1 receptors | |
| AT1A receptor | |
| AT1A receptors | |
| AT2R I | |
| Type-1 angiotensin II receptors | |
| type-1B angiotensin II receptors |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 106165 |
|---|---|
| 145500 | |
| 267430 |
| Mouse chromosome position | 13 16.0 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0010698 | |
| 0001596 | |
| 0004945 | |
| 0031711 | |
| 0046982 | |
| 0004872 | |
| 0007186 | |
| 0007266 | |
| 0007200 | |
| 0019722 | |
| 0060326 | |
| 0007204 | |
| 0051482 | |
| 0001822 | |
| 0034374 | |
| 0006800 | |
| 0033864 | |
| 0032270 | |
| 0010873 | |
| 0050729 | |
| 0010744 | |
| 0032430 | |
| 0002034 | |
| 0001558 | |
| 0042127 | |
| 0050727 | |
| 0003078 | |
| 0003081 | |
| 0019229 | |
| 0042312 | |
| 0002018 | |
| 0016021 | |
| 0005887 | |
| 0005886 | |
| 0001965 | |
| 0017046 | |
| 0043621 | |
| 0004871 | |
| 0001568 | |
| 0002035 | |
| 0071549 | |
| 0042756 | |
| 0043524 | |
| 0045777 | |
| 0090190 | |
| 0050715 | |
| 0001921 | |
| 0006885 | |
| 0002019 | |
| 0001991 | |
| 0002001 | |
| 0043627 | |
| 0007165 | |
| 0005794 | |
| 0016323 | |
| 0005737 | |
| 0031410 | |
| 0030425 | |
| 0012505 | |
| 0005768 | |
| 0016020 | |
| 0031968 | |
| 0031983 | |
| 0012506 | |
| 0008217 | |
| 0004947 | |
| 0016494 |
| Rat chromosome position | 17q12 |
|---|
| Swiss-Prot Accession | P30556 |
|---|---|
| Q53YY0 | |
| Q13063 | |
| Q6NUP5 | |
| Q8TBK4 | |
| P29754 | |
| P25095 | |
| Q13725 | |
| Q9QVS5 |
| PIR ID | JH0621 |
|---|---|
| I39418 | |
| JC1104 | |
| JC2134 |
| Unigene ID | Hs.477887 |
|---|---|
| Hs.723124 | |
| Mm.35062 | |
| Mm.477038 | |
| Rn.9814 | |
| Rn.214849 |
| KEGG ID | hsa:185 |
|---|---|
| mmu:11607 | |
| rno:24180 |
| Swiss-Prot ID | AGTRA_MOUSE |
|---|---|
| AGTR1_HUMAN | |
| AGTRA_RAT | |
| Q53YY0_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00129168 |
|---|---|
| IPI00026885 | |
| IPI00327967 | |
| IPI00797565 |
| Homologene ID | 3556 |
|---|
| RGD ID | 2070 |
|---|
| MGI ID | 87964 |
|---|