| URN | urn:agi-llid:4690 |
|---|---|
| Connectivity | 199 |
| Name | Nck1 |
| Description | non-catalytic region of tyrosine kinase adaptor protein 1 |
| Notes | The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq] |
| Pathway | EndothelinRa -> AP-1/CREB signaling |
|---|---|
| vascular endothelial growth factor signaling pathway |
| GO Molecular Function | protein domain specific binding |
|---|---|
| receptor binding | |
| cytoskeletal adaptor activity | |
| receptor signaling complex scaffold activity | |
| kinase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| endoplasmic reticulum | |
| nucleus | |
| vesicle membrane |
| GO Biological Process | regulation of translation |
|---|---|
| positive regulation of T cell proliferation | |
| positive regulation of actin filament polymerization | |
| T cell activation | |
| cell migration | |
| actin filament organization | |
| signal complex assembly | |
| lamellipodium assembly |
| Group | regulation of translation |
|---|---|
| positive regulation of T cell proliferation | |
| positive regulation of actin filament polymerization | |
| T cell activation | |
| cell migration | |
| actin filament organization | |
| signal complex assembly | |
| lamellipodium assembly | |
| protein domain specific binding | |
| receptor binding | |
| cytoskeletal adaptor activity | |
| receptor signaling complex scaffold activity | |
| kinase activity | |
| cytoplasm | |
| cytosol | |
| endoplasmic reticulum | |
| nucleus | |
| vesicle membrane |
| MedScan ID | 4690 |
|---|
| Hugo ID | 7664 |
|---|
| Human chromosome position | 3q21 |
|---|
| LocusLink ID | 4690 |
|---|---|
| 17973 | |
| 300955 | |
| 29696 |
| Alias | NCK |
|---|---|
| MGC12668 | |
| NCKalpha | |
| cytoplasmic protein NCK1 | |
| nck-1 | |
| NCK tyrosine kinase | |
| melanoma NCK protein | |
| SH2/SH3 adaptor protein NCK-alpha | |
| non-catalytic region of tyrosine kinase | |
| 6330586M15Rik | |
| D230010O13Rik | |
| non-catalytic region of tyrosine kinase adaptor protein 1 | |
| OTTMUSP00000023124 | |
| Nck1_predicted | |
| Cytoplasmic protein NCK I | |
| D230010O13 | |
| NCK adapter | |
| NCK adapter protein 1 | |
| NCK adapter protein I | |
| NCK adaptor | |
| NCK adaptor protein 1 | |
| NCK adaptor protein I | |
| NCK I | |
| NCK1 | |
| NCK1_HUMAN | |
| non-catalytic region of tyrosine kinase adapter protein 1 | |
| non-catalytic region of tyrosine kinase adapter protein I | |
| non-catalytic region of tyrosine kinase adaptor protein I | |
| SH2/SH3 adapter protein NCK-alpha |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600508 |
|---|
| Mouse chromosome position | 9 |
|---|
| GO ID | 0008093 |
|---|---|
| 0019904 | |
| 0005102 | |
| 0030159 | |
| 0042110 | |
| 0007015 | |
| 0016477 | |
| 0030032 | |
| 0042102 | |
| 0030838 | |
| 0006417 | |
| 0007172 | |
| 0005737 | |
| 0005829 | |
| 0005783 | |
| 0005634 | |
| 0012506 | |
| 0016301 |
| Rat chromosome position | 8q31 |
|---|
| Swiss-Prot Accession | P16333 |
|---|---|
| Q99M51 | |
| O55032 | |
| Q8BH99 | |
| Q8BMV0 | |
| Q8BZ27 | |
| Q9Z279 | |
| B2RZ33 | |
| D3DNE3 |
| PIR ID | S08636 |
|---|
| Unigene ID | Hs.477693 |
|---|---|
| Mm.181485 | |
| Mm.471648 | |
| Rn.222513 |
| KEGG ID | hsa:4690 |
|---|---|
| mmu:17973 | |
| rno:300955 |
| Swiss-Prot ID | NCK1_HUMAN |
|---|---|
| B2RZ33_RAT | |
| Q99M51_MOUSE | |
| D3DNE3_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum | |
| Nucleus |
| IPI ID | IPI00028065 |
|---|---|
| IPI00765594 | |
| IPI00453999 | |
| IPI00797459 | |
| IPI00798394 | |
| IPI00793968 | |
| IPI00831379 |
| Homologene ID | 38148 |
|---|
| RGD ID | 1310688 |
|---|
| MGI ID | 109601 |
|---|