| URN | urn:agi-llid:2324 |
|---|---|
| Connectivity | 167 |
| Name | Flt4 |
| Description | fms-related tyrosine kinase 4 |
| Notes | VEGF receptor-related, cell surface associated kinase with growth promoting ability [RGD] |
| Pathway | VEGFR -> AP-1/CREB/MYC signaling |
|---|---|
| VEGFR -> FOXO3A signaling | |
| VEGFR -> CTNNB signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| vascular endothelial growth factor signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| growth factor binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| vascular endothelial growth factor receptor activity | |
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| positive regulation of cell growth | |
| protein amino acid phosphorylation | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway |
| Ariadne Ontology | GFR |
|---|
| Group | GFR |
|---|---|
| positive regulation of cell proliferation | |
| positive regulation of cell growth | |
| protein amino acid phosphorylation | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| growth factor binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| vascular endothelial growth factor receptor activity | |
| receptor activity | |
| membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 2324 |
|---|
| Hugo ID | 3767 |
|---|
| Human chromosome position | 5q35.3 |
|---|
| LocusLink ID | 2324 |
|---|---|
| 14257 | |
| 114110 | |
| 109668 | |
| 103679 |
| Alias | PCL |
|---|---|
| FLT41 | |
| LMPH1A | |
| VEGFR3 | |
| vascular endothelial growth factor receptor 3 | |
| FLT-4 | |
| VEGFR-3 | |
| soluble VEGFR3 variant 1 | |
| soluble VEGFR3 variant 2 | |
| soluble VEGFR3 variant 3 | |
| fms-like tyrosine kinase 4 | |
| tyrosine-protein kinase receptor FLT4 | |
| Chy | |
| AI323512 | |
| RP23-58E13.1 | |
| chylous ascites | |
| OTTMUSP00000005713 | |
| receptor protein tyrosine kinase | |
| vascular endothelial growth factor receptor-3 | |
| BC027302 | |
| FLT4 | |
| FMS-like tyrosine kinase IV | |
| fms-related tyrosine kinase 4 | |
| fms-related tyrosine kinase IV | |
| LOC285682 | |
| LOC360235 | |
| LOC497666 | |
| protein-tyrosine kinase FLT4 | |
| Vascular endothelial growth factor receptor III | |
| VEGF rceptor 3 | |
| VEGF rceptor III | |
| VEGFR III | |
| VEGF-R3 | |
| VGR3 | |
| VGR3_HUMAN | |
| protein-tyrosine kinase FLT4 precursor | |
| VEGFR-3s | |
| expressed sequence AI323512 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 136352 |
|---|---|
| 602089 | |
| 153100 |
| Mouse chromosome position | 11 25.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0019838 | |
| 0000166 | |
| 0004872 | |
| 0016740 | |
| 0004714 | |
| 0005021 | |
| 0008284 | |
| 0006468 | |
| 0007169 | |
| 0048010 | |
| 0005887 | |
| 0016020 | |
| 0016301 | |
| 0004672 | |
| 0004713 | |
| 0030307 | |
| 0016021 | |
| 0005515 | |
| 0005615 | |
| 0004674 | |
| 0001946 |
| Rat chromosome position | 10q22 |
|---|
| Swiss-Prot Accession | P35916 |
|---|---|
| Q86W08 | |
| Q86W07 | |
| Q16067 | |
| Q59F24 | |
| P35917 | |
| Q5SU94 | |
| Q5JCS5 | |
| Q91ZT1 | |
| O35755 | |
| Q91ZT0 | |
| AAB23636 | |
| Q8TAK1 |
| PIR ID | A48999 |
|---|---|
| I58375 |
| Unigene ID | Hs.646917 |
|---|---|
| Mm.3291 | |
| Rn.81043 | |
| Mm.393340 | |
| Hs.415048 | |
| Hs.62492 |
| KEGG ID | hsa:2324 |
|---|---|
| mmu:14257 | |
| rno:114110 |
| EC Number | 2.7.10.1 |
|---|---|
| 2.7.1.112 |
| Swiss-Prot ID | VGFR3_RAT |
|---|---|
| VGFR3_HUMAN | |
| VGFR3_MOUSE | |
| Q86W08_HUMAN | |
| Q5SU94_MOUSE | |
| Q86W07_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00210269 |
|---|---|
| IPI00563647 | |
| IPI00337568 | |
| IPI00273133 | |
| IPI00293565 | |
| IPI00555993 |
| Homologene ID | 7321 |
|---|
| RGD ID | 621737 |
|---|
| MGI ID | 95561 |
|---|---|
| 88402 | |
| 2144119 |
| KEGG pathway | Cytokine-cytokine receptor interaction |
|---|