| URN | urn:agi-llid:2277 |
|---|---|
| Connectivity | 102 |
| Name | Figf |
| Description | c-fos induced growth factor |
| Notes | binds to and activates the tyrosine kinase receptor VEGFR-3 and VEGFR-2; involved in positive regulation of lymphatic blood vessel growth [RGD] |
| Pathway | VEGFR -> AP-1/CREB/MYC signaling |
|---|---|
| VEGFR -> FOXO3A signaling | |
| VEGFR -> CTNNB signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| VEGFR -> CTNND signaling | |
| VEGFR -> STAT signaling | |
| vascular endothelial growth factor signaling pathway |
| GO Molecular Function | chemoattractant activity |
|---|---|
| protein homodimerization activity | |
| growth factor activity | |
| vascular endothelial growth factor receptor binding | |
| platelet-derived growth factor receptor binding | |
| vascular endothelial growth factor receptor 2 binding | |
| vascular endothelial growth factor receptor 3 binding |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| extracellular space | |
| platelet alpha granule lumen |
| GO Biological Process | cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| multicellular organismal development | |
| positive regulation of angiogenesis | |
| cell differentiation | |
| angiogenesis | |
| positive regulation of interleukin-6 production | |
| positive regulation of cell division | |
| positive regulation of mast cell chemotaxis | |
| response to hypoxia | |
| response to interleukin-1 | |
| induction of positive chemotaxis | |
| regulation of vascular endothelial growth factor receptor signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway |
| Ariadne Ontology | GF |
|---|
| Group | GF |
|---|---|
| extracellular region | |
| chemoattractant activity | |
| cell proliferation | |
| positive regulation of cell proliferation | |
| multicellular organismal development | |
| positive regulation of angiogenesis | |
| cell differentiation | |
| angiogenesis | |
| positive regulation of interleukin-6 production | |
| positive regulation of cell division | |
| positive regulation of mast cell chemotaxis | |
| response to hypoxia | |
| response to interleukin-1 | |
| induction of positive chemotaxis | |
| regulation of vascular endothelial growth factor receptor signaling pathway | |
| vascular endothelial growth factor receptor signaling pathway | |
| protein homodimerization activity | |
| growth factor activity | |
| vascular endothelial growth factor receptor binding | |
| platelet-derived growth factor receptor binding | |
| vascular endothelial growth factor receptor 2 binding | |
| vascular endothelial growth factor receptor 3 binding | |
| membrane | |
| extracellular space | |
| platelet alpha granule lumen |
| MedScan ID | 2277 |
|---|
| Hugo ID | 3708 |
|---|
| Human chromosome position | Xp22.31 |
|---|
| LocusLink ID | 2277 |
|---|---|
| 14205 | |
| 360457 | |
| 102900 | |
| 83570 |
| Alias | VEGFD |
|---|---|
| VEGF-D | |
| vascular endothelial growth factor D | |
| c-fos-induced growth factor | |
| AI325264 | |
| RP23-202H24.2 | |
| OTTMUSP00000021049 | |
| c-fos induced growth factor | |
| c-fos induced growth factor (vascular endothelial growth factor d) | |
| Figf | |
| GNB:2766190 | |
| OTTHUMP00000022960 | |
| vascular endothelial growth factor D preproprotein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300091 |
|---|
| Mouse chromosome position | X 70.0 cM |
|---|
| GO ID | 0042056 |
|---|---|
| 0008083 | |
| 0005161 | |
| 0042803 | |
| 0043185 | |
| 0001525 | |
| 0030154 | |
| 0050930 | |
| 0007275 | |
| 0051781 | |
| 0008284 | |
| 0060754 | |
| 0048010 | |
| 0005576 | |
| 0005615 | |
| 0016020 | |
| 0031093 | |
| 0043184 | |
| 0005172 | |
| 0008283 | |
| 0032755 | |
| 0030947 | |
| 0045766 | |
| 0001666 | |
| 0070555 | |
| 0005515 | |
| 0001946 | |
| 0000074 |
| Rat chromosome position | Xq31 |
|---|
| Swiss-Prot Accession | O43915 |
|---|---|
| Q53FX1 | |
| P97946 | |
| Q6P5N9 | |
| O35251 | |
| Q91ZE4 | |
| A2AIH3 | |
| B2R7Z3 |
| Unigene ID | Hs.11392 |
|---|---|
| Mm.297978 | |
| Rn.10796 |
| KEGG ID | hsa:2277 |
|---|---|
| mmu:14205 | |
| rno:360457 |
| Swiss-Prot ID | VEGFD_RAT |
|---|---|
| VEGFD_MOUSE | |
| VEGFD_HUMAN | |
| B2R7Z3_HUMAN | |
| A2AIH3_MOUSE |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00952383 |
|---|---|
| IPI00131038 | |
| IPI00004653 | |
| IPI00207302 |
| Homologene ID | 3288 |
|---|
| RGD ID | 620695 |
|---|
| MGI ID | 108037 |
|---|---|
| 2147877 |
| Source | Curated |
|---|
| KEGG pathway | Focal adhesion |
|---|