Protein Plcg1

URN	urn:agi-llid:5335
Connectivity	772
Name	Plcg1
Description	phospholipase C, gamma 1
Notes	mediates intracellular agonist-induced Ca2+ entry (ACE); serves as a guanine nucleotide exchange factor for the nuclear GTPase PIKE [RGD]

Pathway	FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
	PDGFR -> AP-1/MYC signaling
	VEGFR -> AP-1/CREB/MYC signaling
	HGFR -> AP-1/CREB/MYC signaling
	AngiopoietinR -> AP-1 signaling
	ErythropoietinR -> AP-1/CREB/MYC signaling
	ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
	EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
	EGFR -> NCOR2 signaling
	NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
	GDNF -> HSF1 signaling
	SELE -> ELK-SRF signaling
	FibronectinR -> AP-1/ELK-SRF/SREBF signaling
	ICAM1 -> AP-1/CREB/ELK-SRF signaling
	EGFR -> SMAD1 signaling
	EGFR -> AP-1/ATF2 signaling
	ERBB2/3 -> EP300/ETS/ETV/SP1 signaling
	EGFR/ERBB2 -> HIF1A signaling
	EGFR/ERBB2 -> TP53 signaling
	FGFR -> RUNX2 signaling
	KIT -> MITF signaling
	VEGFR -> NFATC signaling
	VEGFR -> ATF/CREB/ELK-SRF signaling
	DopamineR2 -> AP-1/CREB/ELK-SRF signaling
	EDG2 -> ELK-SRF signaling
	FcIgER -> ELK-SRF signaling
	FcIgER -> NFATC1 signaling
	CD2 -> NFATC1 signaling
	T-cell receptor -> AP-1 signaling
	T-cell receptor -> ATF/CREB signaling
	T-cell receptor -> CREBBP signaling
	T-cell receptor -> NF-kB signaling
	T-cell receptor -> NFATC signaling
	PTPRC -> BCL6 signaling
	UrokinaseR -> ELK-SRF signaling
	vascular endothelial growth factor signaling pathway
	scatter factor-hepatocyte growth factor signaling pathway

GO Molecular Function	signal transducer activity
	hydrolase activity
	phosphoprotein binding
	insulin receptor binding
	glutamate receptor binding
	calcium ion binding
	phosphoric diester hydrolase activity
	phospholipase C activity
	phosphoinositide phospholipase C activity
	receptor signaling protein activity

GO Biological Process	vesicle-mediated transport
	interspecies interaction between organisms
	in utero embryonic development
	positive regulation of epithelial cell migration
	signal transduction
	positive regulation of calcium ion transport via store-operated calcium channel activity
	inositol trisphosphate biosynthetic process
	phospholipid catabolic process
	T cell receptor signaling pathway
	response to gravity
	response to organic nitrogen
	response to hydrogen peroxide
	response to morphine
	lipid metabolic process
	lipid catabolic process
	calcium ion transport
	intracellular signaling pathway

Ariadne Ontology	Lipid degradation
	PLC

Group	Lipid degradation
	PLC
	vesicle-mediated transport
	interspecies interaction between organisms
	in utero embryonic development
	positive regulation of epithelial cell migration
	signal transduction
	positive regulation of calcium ion transport via store-operated calcium channel activity
	inositol trisphosphate biosynthetic process
	phospholipid catabolic process
	T cell receptor signaling pathway
	response to gravity
	response to organic nitrogen
	response to hydrogen peroxide
	response to morphine
	lipid metabolic process
	lipid catabolic process
	calcium ion transport
	intracellular signaling pathway
	signal transducer activity
	hydrolase activity
	phosphoprotein binding
	insulin receptor binding
	glutamate receptor binding
	calcium ion binding
	phosphoric diester hydrolase activity
	phospholipase C activity
	phosphoinositide phospholipase C activity
	receptor signaling protein activity
	plasma membrane
	neuron projection
	cytoplasm
	cytosol

MedScan ID	5335

Hugo ID	9065

Human chromosome position	20q12-q13.1

Alias	PLC1
	NCKAP3
	PLC-II
	PLC148
	PLCgamma1
	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
	PLC-148
	PLC-gamma-1
	OTTHUMP00000178982
	phospholipase C-II
	phospholipase C-148
	phosphoinositidase C
	phospholipase C-gamma-1
	inositoltrisphosphohydrolase
	phosphoinositide phospholipase C
	phosphatidylinositol phospholipase C
	triphosphoinositide phosphodiesterase
	phosphoinositide phospholipase C-gamma-1
	monophosphatidylinositol phosphodiesterase
	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
	phospholipase C, gamma 1 (formerly subtype 148)
	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
	Cded
	Plc-1
	Plcg-1
	AI894140
	Plc-gamma1
	RP23-393F23.4
	OTTMUSP00000001135
	OTTMUSP00000017125
	cell differentiation and embryonic development
	PPLCA
	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate phosphodiesterase
	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma I
	LOC381402
	OTTHUMP00000031787
	phospholipase C gamma 1
	Phospholipase C-gamma
	Phospholipase C-gamma I
	PIG I
	PIG1
	PIG1_HUMAN
	PIG1_RAT
	PLC I
	Plcg I
	Plcg1
	PLC-gamma
	PLC-gamma I
	phospholipase C, gamma 1
	PLC-148s
	cell differentiating and embryonic development

OMIM ID	172420

Mouse chromosome position	2 92.0 cM

Rat chromosome position	3q42

EC Number	3.1.4.11
	3.1.4.3

Cell Localization	Plasma membrane
	Cytoplasm

Homologene ID	1997

RGD ID	3347

Source	Curated