| URN | urn:agi-llid:5747 |
|---|---|
| Connectivity | 1098 |
| Name | Ptk2 |
| Description | PTK2 protein tyrosine kinase 2 |
| Notes | tyrosine kinase that is enriched in focal adhesions; may regulate mechanical signal transduction in cardiac myocytes [RGD] |
| Pathway | FibronectinR -> NF-kB signaling |
|---|---|
| FibronectinR -> CTNNB signaling | |
| NCAM1 -> CREB/ELK-SRF/MYC signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| VEGFR -> CTNNB signaling | |
| VEGFR -> STAT signaling | |
| CholinergicRn -> CREB signaling | |
| EphrinB -> JUN signaling | |
| vascular endothelial growth factor signaling pathway | |
| integrin mediated signaling pathway | |
| integrin mediated signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| nucleotide binding | |
| transferase activity | |
| protein complex binding | |
| SH2 domain binding | |
| integrin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| lamellipodium | |
| cytoplasm | |
| cytosol | |
| nucleolus | |
| nuclear body | |
| cytoskeleton | |
| nucleus | |
| basolateral plasma membrane | |
| apical plasma membrane | |
| cell junction | |
| intercalated disc | |
| focal adhesion | |
| sarcolemma |
| GO Biological Process | cellular component movement |
|---|---|
| blood vessel development | |
| angiogenesis | |
| negative regulation of synaptogenesis | |
| negative regulation of axonogenesis | |
| positive regulation of glial cell proliferation | |
| vasculogenesis | |
| fat cell differentiation | |
| central nervous system neuron axonogenesis | |
| positive regulation of vasodilation | |
| positive regulation of synaptic transmission | |
| microtubule cytoskeleton organization | |
| positive regulation of cell adhesion | |
| positive regulation of cell growth | |
| extracellular matrix organization | |
| MAPKKK cascade | |
| JNK cascade | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of phagocytosis | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell migration | |
| negative regulation of cell migration | |
| negative regulation of apoptosis | |
| endothelial cell migration | |
| neuron migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| phosphorylation | |
| cellular chloride ion homeostasis | |
| signal complex assembly | |
| response to mechanical stimulus | |
| response to organic substance | |
| response to drug | |
| response to organic nitrogen | |
| response to arsenic | |
| response to organic cyclic substance | |
| response to estradiol stimulus | |
| response to glucose stimulus | |
| negative regulation of organ growth | |
| establishment of nucleus localization | |
| integrin-mediated signaling pathway |
| Ariadne Ontology | FAK |
|---|
| Group | FAK |
|---|---|
| cellular component movement | |
| blood vessel development | |
| angiogenesis | |
| negative regulation of synaptogenesis | |
| negative regulation of axonogenesis | |
| positive regulation of glial cell proliferation | |
| vasculogenesis | |
| fat cell differentiation | |
| central nervous system neuron axonogenesis | |
| positive regulation of vasodilation | |
| positive regulation of synaptic transmission | |
| microtubule cytoskeleton organization | |
| positive regulation of cell adhesion | |
| positive regulation of cell growth | |
| extracellular matrix organization | |
| MAPKKK cascade | |
| JNK cascade | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of phagocytosis | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell migration | |
| negative regulation of cell migration | |
| negative regulation of apoptosis | |
| endothelial cell migration | |
| neuron migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| phosphorylation | |
| cellular chloride ion homeostasis | |
| signal complex assembly | |
| response to mechanical stimulus | |
| response to organic substance | |
| response to drug | |
| response to organic nitrogen | |
| response to arsenic | |
| response to organic cyclic substance | |
| response to estradiol stimulus | |
| response to glucose stimulus | |
| negative regulation of organ growth | |
| establishment of nucleus localization | |
| integrin-mediated signaling pathway | |
| signal transducer activity | |
| nucleotide binding | |
| transferase activity | |
| protein complex binding | |
| SH2 domain binding | |
| integrin binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity | |
| membrane | |
| plasma membrane | |
| lamellipodium | |
| cytoplasm | |
| cytosol | |
| nucleolus | |
| nuclear body | |
| cytoskeleton | |
| nucleus | |
| basolateral plasma membrane | |
| apical plasma membrane | |
| cell junction | |
| intercalated disc | |
| focal adhesion | |
| sarcolemma |
| MedScan ID | 5747 |
|---|
| Hugo ID | 9611 |
|---|
| Human chromosome position | 8q24-qter |
|---|
| LocusLink ID | 5747 |
|---|---|
| 14083 | |
| 25614 |
| Alias | FAK |
|---|---|
| FADK | |
| FAK1 | |
| FRNK | |
| pp125FAK | |
| focal adhesion kinase 1 | |
| FADK 1 | |
| protein-tyrosine kinase 2 | |
| FAK-related non-kinase polypeptide | |
| KIAA4203 | |
| mKIAA4203 | |
| protein tyrosine kinase 2 | |
| focal adhesion kinase-related nonkinase | |
| FADK I | |
| FAK I | |
| focal adhesion kinase | |
| Focal adhesion kinase I | |
| p125FAK | |
| PTK2 | |
| PTK2 protein tyrosine kinase | |
| PTK2 protein tyrosine kinase 2 | |
| PTK2 protein tyrosine kinase II | |
| Protein tyrosine kinase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600758 |
|---|
| Mouse chromosome position | 15 42.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0042169 | |
| 0004715 | |
| 0000166 | |
| 0004713 | |
| 0004871 | |
| 0016740 | |
| 0001525 | |
| 0001568 | |
| 0021955 | |
| 0043542 | |
| 0040023 | |
| 0030198 | |
| 0007229 | |
| 0000226 | |
| 0050771 | |
| 0046621 | |
| 0051964 | |
| 0001764 | |
| 0046777 | |
| 0006468 | |
| 0007172 | |
| 0001570 | |
| 0016324 | |
| 0030054 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0005925 | |
| 0030027 | |
| 0005886 | |
| 0005178 | |
| 0016301 | |
| 0032403 | |
| 0004672 | |
| 0007254 | |
| 0000165 | |
| 0030644 | |
| 0006928 | |
| 0043066 | |
| 0030336 | |
| 0045785 | |
| 0030307 | |
| 0030335 | |
| 0060252 | |
| 0050766 | |
| 0014911 | |
| 0048661 | |
| 0050806 | |
| 0045909 | |
| 0016323 | |
| 0014704 | |
| 0016020 | |
| 0016604 | |
| 0005730 | |
| 0005634 | |
| 0042383 | |
| 0045444 | |
| 0016310 | |
| 0046685 | |
| 0042493 | |
| 0032355 | |
| 0009749 | |
| 0009612 | |
| 0014070 | |
| 0010243 | |
| 0010033 | |
| 0005515 | |
| 0004674 | |
| 0005488 |
| Rat chromosome position | 7q34 |
|---|
| Swiss-Prot Accession | Q05397 |
|---|---|
| Q658W2 | |
| Q8IYN9 | |
| Q59GM6 | |
| Q59GN8 | |
| Q8N9D7 | |
| P34152 | |
| Q2VQT9 | |
| O35346 | |
| Q62898 | |
| Q62899 | |
| O08578 | |
| Q5DTH7 | |
| Q8C513 | |
| Q8CFH7 | |
| Q8CHM2 | |
| Q8K2S0 | |
| Q9DAW3 | |
| Q14291 | |
| Q9UD85 | |
| Q62900 |
| PIR ID | A46166 |
|---|---|
| I53012 | |
| PC1225 |
| Unigene ID | Hs.395482 |
|---|---|
| Mm.254494 | |
| Rn.2809 |
| KEGG ID | hsa:5747 |
|---|---|
| mmu:14083 | |
| rno:25614 |
| EC Number | 2.7.10.2 |
|---|---|
| 2.7.10.1 |
| Swiss-Prot ID | FAK1_MOUSE |
|---|---|
| FAK1_HUMAN | |
| FAK1_RAT | |
| Q8IYN9_HUMAN | |
| Q658W2_HUMAN |
| Cell Localization | Cell junction |
|---|---|
| focal adhesion | |
| Cell membrane | |
| Cytoplasm |
| IPI ID | IPI00113563 |
|---|---|
| IPI00230629 | |
| IPI00338858 | |
| IPI00625418 | |
| IPI00875543 | |
| IPI00895208 | |
| IPI00895269 | |
| IPI00895396 | |
| IPI00012885 | |
| IPI00216217 | |
| IPI00216218 | |
| IPI00871963 | |
| IPI00476238 | |
| IPI00793270 | |
| IPI00413961 | |
| IPI00789953 | |
| IPI00749256 | |
| IPI00797735 | |
| IPI00230630 | |
| IPI00231161 | |
| IPI00561059 |
| Homologene ID | 7314 |
|---|
| RGD ID | 3443 |
|---|
| MGI ID | 95481 |
|---|
| Source | Curated |
|---|