| URN | urn:agi-llid:5590 |
|---|---|
| Connectivity | 605 |
| Name | Prkcz |
| Description | protein kinase C, zeta |
| Notes | Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Pathway | vascular endothelial growth factor signaling pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| potassium channel regulator activity | |
| transferase activity | |
| insulin receptor substrate binding | |
| phospholipase binding | |
| protein kinase binding | |
| ATP binding | |
| metal ion binding | |
| zinc ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein kinase C activity |
| GO Cellular Component | protein complex |
|---|---|
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| membrane raft | |
| endosome | |
| perinuclear region of cytoplasm | |
| cell cortex | |
| cytosol | |
| apical cortex | |
| filamentous actin | |
| membrane fraction | |
| microsome | |
| tight junction |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| positive regulation of synaptic transmission | |
| long-term memory | |
| signal transduction | |
| microtubule cytoskeleton organization | |
| vesicle transport along microtubule | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of peptidyl-tyrosine phosphorylation | |
| activation of protein kinase B activity | |
| positive regulation of cell-matrix adhesion | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| protein amino acid phosphorylation | |
| peptidyl-serine phosphorylation | |
| membrane depolarization | |
| membrane hyperpolarization | |
| actin cytoskeleton reorganization | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| negative regulation of protein complex assembly | |
| positive regulation of protein transport | |
| positive regulation of glucose import | |
| protein heterooligomerization | |
| cell surface receptor linked signaling pathway | |
| intracellular signaling pathway | |
| negative regulation of hydrolase activity | |
| activation of phospholipase D activity |
| Ariadne Ontology | PKC |
|---|
| Group | PKC |
|---|---|
| positive regulation of cell proliferation | |
| positive regulation of synaptic transmission | |
| long-term memory | |
| signal transduction | |
| microtubule cytoskeleton organization | |
| vesicle transport along microtubule | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of peptidyl-tyrosine phosphorylation | |
| activation of protein kinase B activity | |
| positive regulation of cell-matrix adhesion | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| protein amino acid phosphorylation | |
| peptidyl-serine phosphorylation | |
| membrane depolarization | |
| membrane hyperpolarization | |
| actin cytoskeleton reorganization | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| negative regulation of protein complex assembly | |
| positive regulation of protein transport | |
| positive regulation of glucose import | |
| protein heterooligomerization | |
| cell surface receptor linked signaling pathway | |
| intracellular signaling pathway | |
| negative regulation of hydrolase activity | |
| activation of phospholipase D activity | |
| nucleotide binding | |
| potassium channel regulator activity | |
| transferase activity | |
| insulin receptor substrate binding | |
| phospholipase binding | |
| protein kinase binding | |
| ATP binding | |
| metal ion binding | |
| zinc ion binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein kinase C activity | |
| protein complex | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| membrane raft | |
| endosome | |
| perinuclear region of cytoplasm | |
| cell cortex | |
| cytosol | |
| apical cortex | |
| filamentous actin | |
| membrane fraction | |
| microsome | |
| tight junction |
| MedScan ID | 5590 |
|---|
| Hugo ID | 9412 |
|---|
| Human chromosome position | 1p36.33-p36.2 |
|---|
| LocusLink ID | 5590 |
|---|---|
| 18762 | |
| 25522 |
| Alias | PKC2 |
|---|---|
| PKC-ZETA | |
| protein kinase C zeta type | |
| nPKC-zeta | |
| Pkcz | |
| C80388 | |
| R74924 | |
| zetaPKC | |
| AI098070 | |
| aPKCzeta | |
| RP23-298E4.6 | |
| OTTMUSP00000011359 | |
| OTTMUSP00000011362 | |
| atypical protein kinase C | |
| protein kinase C zeta subspecies | |
| r14-3-3 | |
| 14-3-3-zetaisoform | |
| 14 - 3 - 3 - zeta isoform | |
| OTTHUMP00000001368 | |
| OTTHUMP00000044160 | |
| PRKCZ | |
| protein kinase C, zeta |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 176982 |
|---|
| Mouse chromosome position | 4 83.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0043560 | |
| 0046872 | |
| 0000166 | |
| 0043274 | |
| 0015459 | |
| 0004697 | |
| 0019901 | |
| 0004674 | |
| 0016740 | |
| 0008270 | |
| 0031532 | |
| 0031584 | |
| 0032148 | |
| 0006916 | |
| 0007166 | |
| 0023034 | |
| 0007616 | |
| 0051899 | |
| 0060081 | |
| 0000226 | |
| 0051346 | |
| 0046627 | |
| 0050732 | |
| 0031333 | |
| 0018105 | |
| 0008284 | |
| 0001954 | |
| 0046326 | |
| 0051222 | |
| 0050806 | |
| 0051291 | |
| 0007165 | |
| 0047496 | |
| 0045179 | |
| 0005938 | |
| 0005737 | |
| 0005829 | |
| 0005768 | |
| 0031941 | |
| 0005624 | |
| 0045121 | |
| 0005792 | |
| 0048471 | |
| 0005886 | |
| 0005923 | |
| 0016301 | |
| 0004672 | |
| 0032869 | |
| 0008286 | |
| 0043066 | |
| 0006468 | |
| 0043234 | |
| 0005625 | |
| 0007242 | |
| 0019992 | |
| 0005515 | |
| 0004700 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | A8MU64 |
|---|---|
| Q05513 | |
| Q3V341 | |
| A2AD76 | |
| Q02956 | |
| Q3UHM5 | |
| Q6PF82 | |
| Q7TST7 | |
| P09217 | |
| Q9JLP6 | |
| A8K4N0 | |
| Q15207 | |
| Q5SYT5 | |
| Q969S4 |
| PIR ID | JN0877 |
|---|---|
| A30314 | |
| JC1480 |
| Unigene ID | Hs.496255 |
|---|---|
| Mm.28561 | |
| Rn.1109 |
| KEGG ID | hsa:5590 |
|---|---|
| mmu:18762 | |
| rno:25522 |
| EC Number | 2.7.11.13 |
|---|---|
| 2.7.11.1 |
| Swiss-Prot ID | KPCZ_HUMAN |
|---|---|
| KPCZ_RAT | |
| KPCZ_MOUSE | |
| A8MU64_HUMAN | |
| Q3V341_MOUSE | |
| A2AD76_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Endosome |
| IPI ID | IPI00013749 |
|---|---|
| IPI00212818 | |
| IPI00133596 | |
| IPI00651700 | |
| IPI00648131 | |
| IPI00828578 | |
| IPI00515054 | |
| IPI00655886 | |
| IPI00852970 | |
| IPI00648599 | |
| IPI00648818 | |
| IPI00649099 |
| Homologene ID | 55681 |
|---|
| RGD ID | 3399 |
|---|
| MGI ID | 97602 |
|---|