| URN | urn:agi-llid:7186 |
|---|---|
| Total Entities | 0 |
| Connectivity | 557 |
| Name | Traf2 |
| Description | Tnf receptor-associated factor 2 (predicted) |
| Notes | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. |
| Ariadne Ontology | TNFRAP |
|---|---|
| Secreted proteins |
| GO Molecular Function | lipid binding |
|---|---|
| protein complex binding | |
| receptor binding | |
| enzyme binding | |
| CD40 receptor binding | |
| tumor necrosis factor receptor binding | |
| thioesterase binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| ubiquitin protein ligase binding | |
| sphingolipid binding | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| signal transducer activity |
| GO Cellular Component | membrane raft |
|---|---|
| CD40 receptor complex | |
| internal side of plasma membrane | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| cell cortex |
| GO Biological Process | positive regulation of extrinsic apoptotic signaling pathway |
|---|---|
| activation of NF-kappaB-inducing kinase activity | |
| regulation of JNK cascade | |
| positive regulation of JUN kinase activity | |
| signal transduction | |
| apoptotic signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| negative regulation of glial cell apoptotic process | |
| positive regulation of T cell activation | |
| regulation of immunoglobulin secretion | |
| regulation of apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein autoubiquitination | |
| protein K63-linked ubiquitination | |
| apoptotic process | |
| cellular protein complex assembly | |
| positive regulation of T cell cytokine production | |
| innate immune response | |
| positive regulation of interleukin-2 production | |
| protein catabolic process | |
| protein complex assembly | |
| protein heterooligomerization | |
| protein homotrimerization | |
| positive regulation of protein homodimerization activity |
| Pathway | Apoptosis |
|---|---|
| EctodysplasinR -> NF-kB signaling | |
| EctodysplasinR -> AP-1 signaling | |
| TNFRSF6 -> HSF1 signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| NGFR -> MEF signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| NGFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| EctodysplasinR -> LEF1 signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| Unfolded Protein Response | |
| FASLG Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| TNF/NF-kB Expression Targets | |
| TNF/AP-1 Expression Targets | |
| p38 MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway | |
| p38 MAPK signaling pathway | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | TNFRAP |
|---|---|
| positive regulation of extrinsic apoptotic signaling pathway | |
| activation of NF-kappaB-inducing kinase activity | |
| regulation of JNK cascade | |
| positive regulation of JUN kinase activity | |
| signal transduction | |
| apoptotic signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| negative regulation of glial cell apoptotic process | |
| positive regulation of T cell activation | |
| regulation of immunoglobulin secretion | |
| regulation of apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein autoubiquitination | |
| protein K63-linked ubiquitination | |
| apoptotic process | |
| cellular protein complex assembly | |
| positive regulation of T cell cytokine production | |
| innate immune response | |
| positive regulation of interleukin-2 production | |
| protein catabolic process | |
| protein complex assembly | |
| protein heterooligomerization | |
| protein homotrimerization | |
| positive regulation of protein homodimerization activity | |
| lipid binding | |
| protein complex binding | |
| receptor binding | |
| enzyme binding | |
| CD40 receptor binding | |
| tumor necrosis factor receptor binding | |
| thioesterase binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| ubiquitin protein ligase binding | |
| sphingolipid binding | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| signal transducer activity | |
| membrane raft | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| cell cortex | |
| Secreted proteins |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| MedScan ID | 7186 |
|---|
| Hugo ID | 12032 |
|---|
| Human chromosome position | 9q34 |
|---|
| LocusLink ID | 7186 |
|---|---|
| 22030 | |
| 311786 | |
| 98924 | |
| 512355 | |
| 557526 | |
| 327134 |
| Alias | TRAP |
|---|---|
| TRAP3 | |
| MGC:45012 | |
| TNF receptor-associated factor 2 | |
| E3 ubiquitin-protein ligase TRAF2 | |
| tumor necrosis factor type 2 receptor associated protein 3 | |
| tumor necrosis factor type 2 receptor-associated protein 3 | |
| AI325259 | |
| RP23-464C2.1 | |
| TNF receptor-associated factor II | |
| TRA2 | |
| tumour necrosis factor type 2 receptor associated protein 3 | |
| tumour necrosis factor receptor associated factor 2 | |
| Tumor necrosis factor type 2 receptor associated protein III | |
| Tumor necrosis factor receptor associated factor 2 | |
| TRAF2 | |
| tumour necrosis factor type 2 receptor associated protein III | |
| LOC203234 | |
| OTTMUSP00000013079 | |
| OTTMUSP00000013078 | |
| OTTHUMP00000064745 | |
| OTTHUMP00000022625 | |
| TRA2_HUMAN | |
| Traf2_predicted | |
| Tumor necrosis factor type 2 receptor associated protein 3 | |
| Tumor necrosis factor type 2 receptor associated protein III | |
| Tnf receptor-associated factor 2 (predicted) | |
| fd14c07 | |
| si:dkey-170o10.1 | |
| wu:fd14c07 | |
| chromosome | |
| scaffold | |
| tumor necrosis factor receptor associate factor-2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 601895 |
|---|
| Unigene ID | Hs.522506 |
|---|---|
| Mm.3399 | |
| Rn.105232 | |
| Bt.1714 | |
| Dr.78607 |
| KEGG ID | hsa:7186 |
|---|---|
| mmu:22030 | |
| rno:311786 |
| Swiss-Prot Accession | Q12933 |
|---|---|
| P39429 | |
| Q3TWR1 | |
| Q3U8L1 | |
| Q8C6X9 | |
| Q8CAQ7 | |
| B5DFH7 | |
| A8K107 | |
| B4DPJ7 | |
| Q7Z337 | |
| Q96NT2 | |
| A2AJA3 | |
| O54896 | |
| Q5T5T6 | |
| Q5T1L8 | |
| Q53GH0 | |
| Q5T1L7 | |
| Q5T1L6 | |
| Q5T1L5 |
| EC Number | 6.3.2.- |
|---|
| GO ID | 0005174 |
|---|---|
| 0019899 | |
| 0031435 | |
| 0004871 | |
| 0046625 | |
| 0031996 | |
| 0005164 | |
| 0031625 | |
| 0004842 | |
| 0008270 | |
| 0007250 | |
| 0006919 | |
| 0008633 | |
| 0006915 | |
| 0043623 | |
| 0045087 | |
| 0034351 | |
| 0043507 | |
| 0051092 | |
| 0050870 | |
| 0002726 | |
| 2001238 | |
| 0032743 | |
| 0090073 | |
| 0051091 | |
| 0070534 | |
| 0051865 | |
| 0030163 | |
| 0006461 | |
| 0070207 | |
| 0042981 | |
| 0051023 | |
| 0007165 | |
| 0033209 | |
| 0035631 | |
| 0005938 | |
| 0005737 | |
| 0005829 | |
| 0009898 | |
| 0045121 | |
| 0016874 | |
| 0008289 | |
| 0046872 | |
| 0032403 | |
| 0005102 | |
| 0043066 | |
| 0051291 | |
| 0046328 | |
| 0043234 | |
| 0008624 | |
| 0006916 | |
| 0004872 | |
| 0005515 | |
| 0000151 | |
| 0016567 |
| PIR ID | S56163 |
|---|---|
| I61512 |
| Swiss-Prot ID | TRAF2_HUMAN |
|---|---|
| TRAF2_MOUSE | |
| A8K107_HUMAN | |
| Q3U8L1_MOUSE | |
| B5DFH7_RAT | |
| Q8C6X9_MOUSE | |
| Q3TWR1_MOUSE | |
| Q8CAQ7_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00030278 |
|---|---|
| IPI00292635 | |
| IPI00970911 | |
| IPI00970988 | |
| IPI00135901 | |
| IPI00271450 | |
| IPI00371898 | |
| IPI00647767 | |
| IPI00384922 | |
| IPI00646169 | |
| IPI00644377 | |
| IPI00776867 |
| Mouse chromosome position | 2 |
|---|---|
| 2 A3 |
| Rat chromosome position | 3p13 |
|---|
| Homologene ID | 22520 |
|---|
| MGI ID | 101835 |
|---|---|
| 2138907 |
| RGD ID | 1310457 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 9q34 |
|---|
| Microarray ID | 98416_at |
|---|
| FunctionalClass | metal ion binding |
|---|---|
| protein binding | |
| receptor | |
| signal transducer | |
| zinc ion binding | |
| ubiquitin-protein ligase | |
| protein complex binding |
| Mus musculus Chromosome position | 2 A3 |
|---|---|
| 2 |
| Rattus norvegicus Chromosome position | 3p13 |
|---|
| Bos taurus Chromosome position | 11 |
|---|