Protein Tradd

URN	urn:agi-llid:8717
Total Entities	0
Connectivity	239
Name	Tradd
Description	TNFRSF1A-associated via death domain
Notes	human homolog plays a role in neurotrophin receptor p75(NTR) mediated anti-apoptotis [RGD]

Ariadne Ontology	TNFRAP

GO Molecular Function	binding, bridging
	protein complex binding
	tumor necrosis factor receptor binding
	kinase binding
	death domain binding
	signal transducer activity

GO Biological Process	positive regulation of I-kappaB kinase-NF-kappaB cascade
	signal transduction
	apoptotic signaling pathway
	extrinsic apoptotic signaling pathway
	tumor necrosis factor-mediated signaling pathway
	induction of apoptosis
	regulation of apoptotic process
	activation of cysteine-type endopeptidase activity involved in apoptotic process
	apoptotic process
	positive regulation of hair follicle development
	protein heterooligomerization

Pathway	Apoptosis
	TNFRSF6 -> HSF1 signaling
	NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
	TNFRSF5/6 -> RB1/E2F signaling
	TNFR -> CREB/ELK-SRF signaling
	TNFR -> NF-kB signaling
	NGFR -> MEF signaling
	TNFRSF6 -> DDIT3 signaling
	NGFR -> NF-kB signaling
	TNFR -> AP-1/ATF/TP53 signaling
	TNFRSF6 -> FOXO3A signaling
	TNFRSF1A -> AP-1/ATF/TP53 signaling
	TNFRSF1A -> CREB/ELK-SRF signaling
	FASLG Expression Targets
	NGF/FOXO/MYCN/ELK-SRF Expression Targets
	BDNF Expression Targets
	NTF3 Expression Targets
	NTF4 Expression Targets
	TNFSF10 Expression Targets
	LTA Expression Targets
	TNF/CREB Expression Targets
	TNF/TP53/ATF Expression Targets
	TNF/ELK-SRF Expression Targets
	NGF/AP-1/TP53/MYC Expression Targets
	NGF/CREB/CEBPB/MEF2A Expression Targets
	NGF/SMAD3/NF-kB Expression Targets
	TNF/NF-kB Expression Targets
	TNF/AP-1 Expression Targets
	Toll-like receptor signaling pathway
	tumor necrosis factor signaling pathway
	tumor necrosis factor mediated signaling pathway
	tumor necrosis factor signaling pathway
	tumor necrosis factor mediated signaling pathway

Group	TNFRAP
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	signal transduction
	apoptotic signaling pathway
	extrinsic apoptotic signaling pathway
	tumor necrosis factor-mediated signaling pathway
	induction of apoptosis
	regulation of apoptotic process
	activation of cysteine-type endopeptidase activity involved in apoptotic process
	apoptotic process
	positive regulation of hair follicle development
	protein heterooligomerization
	binding, bridging
	protein complex binding
	tumor necrosis factor receptor binding
	kinase binding
	death domain binding
	signal transducer activity
	membrane raft
	protein complex
	receptor complex
	cytoplasm
	cytosol
	cytoskeleton
	nucleus

Source	Curated

MedScan ID	8717

Hugo ID	12030

Human chromosome position	16q22

Alias	Hs.89862
	tumor necrosis factor receptor type 1-associated DEATH domain protein
	TNFR1-associated death domain protein
	tumor necrosis factor receptor-1-associated protein
	tumor necrosis factor receptor type 1 associated death domain protein
	AA930854
	9130005N23Rik
	TNF receptor 1 associated signal transducer
	TNFRSF1A-associated via death domain
	TRADD
	tumour necrosis factor receptor-1-associated protein
	tumour necrosis factor receptor type 1 associated DEATH domain protein
	9130005N23
	TNFR-associated DEATH domain protein
	TNFR-associated DD protein
	MGC11078
	LOC123915
	RIKEN cDNA 9130005N23 gene
	MGC103556
	chromosome
	fc59e02
	scaffold
	wu:fc59e02
	zgc:103556

OMIM ID	603500

PIR ID	A56911

Mouse chromosome position	8 51.0 cM

Rat chromosome position	19q11

Homologene ID	2807

MGI ID	109200
	2142447

RGD ID	621313

Primary Cell Localization	Cytoplasm

Homo sapiens Chromosome position	16q22

Mus musculus Chromosome position	8 51.0 cM
	8

KEGG pathway	Adipocytokine signaling pathway
	Apoptosis

Rattus norvegicus Chromosome position	19q11

Bos taurus Chromosome position	18