Protein Cyld

URN	urn:agi-llid:1540
Total Entities	0
Connectivity	276
Name	Cyld
Description	cylindromatosis (turban tumor syndrome)
Notes	This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GO Molecular Function	proline-rich region binding
	protein kinase binding
	metal ion binding
	zinc ion binding
	hydrolase activity
	peptidase activity
	ubiquitin thiolesterase activity
	cysteine-type peptidase activity
	ubiquitin-specific protease activity
	structural constituent of ribosome

GO Cellular Component	membrane
	microtubule
	cytoplasmic microtubule
	extrinsic to internal side of plasma membrane
	ribosome
	midbody
	plasma membrane
	cytoplasm
	perinuclear region of cytoplasm
	cytosol
	cytoskeleton

GO Biological Process	cell cycle
	regulation of microtubule cytoskeleton organization
	regulation of mitotic cell cycle
	negative regulation of canonical Wnt receptor signaling pathway
	positive regulation of extrinsic apoptotic signaling pathway
	negative regulation of NF-kappaB import into nucleus
	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
	nucleotide-binding oligomerization domain containing signaling pathway
	Wnt receptor signaling pathway
	negative regulation of NF-kappaB transcription factor activity
	induction of apoptosis
	translation
	protein K63-linked deubiquitination
	ubiquitin-dependent protein catabolic process
	innate immune response
	negative regulation of type I interferon production
	proteolysis

Pathway	nuclear factor kappa B signaling pathway
	tumor necrosis factor signaling pathway
	tumor necrosis factor mediated signaling pathway

Group	cell cycle
	regulation of microtubule cytoskeleton organization
	regulation of mitotic cell cycle
	negative regulation of canonical Wnt receptor signaling pathway
	positive regulation of extrinsic apoptotic signaling pathway
	negative regulation of NF-kappaB import into nucleus
	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
	nucleotide-binding oligomerization domain containing signaling pathway
	Wnt receptor signaling pathway
	negative regulation of NF-kappaB transcription factor activity
	induction of apoptosis
	translation
	protein K63-linked deubiquitination
	ubiquitin-dependent protein catabolic process
	innate immune response
	negative regulation of type I interferon production
	proteolysis
	proline-rich region binding
	protein kinase binding
	metal ion binding
	zinc ion binding
	hydrolase activity
	peptidase activity
	ubiquitin thiolesterase activity
	cysteine-type peptidase activity
	ubiquitin-specific protease activity
	structural constituent of ribosome
	membrane
	microtubule
	cytoplasmic microtubule
	extrinsic to internal side of plasma membrane
	ribosome
	midbody
	plasma membrane
	cytoplasm
	perinuclear region of cytoplasm
	cytosol
	cytoskeleton

MedScan ID	1540
	649965

Hugo ID	2584

Human chromosome position	16q12.1

Alias	EAC
	MFT
	SBS
	TEM
	BRSS
	CDMT
	MFT1
	CYLD1
	CYLDI
	USPL2
	HSPC057
	ubiquitin carboxyl-terminal hydrolase CYLD
	ubiquitin thioesterase CYLD
	deubiquitinating enzyme CYLD
	ubiquitin thiolesterase CYLD
	ubiquitin specific peptidase like 2
	ubiquitin-specific-processing protease CYLD
	probable ubiquitin carboxyl-terminal hydrolase CYLD
	mKIAA0849
	2010013M14Rik
	2900009M21Rik
	C130039D01Rik
	Rp1
	Rp1h
	LRRGT00003
	retinitis pigmentosa 1 homolog
	Kiaa0849
	FLJ78684
	Spiegler-Brooke syndrome gene
	multiple familial trichoepithelioma gene
	Spiegler-Brooke syndrome protein
	turban tumour syndrome protein
	turban tumor syndrome gene
	FLJ31664
	turban tumour syndrome gene
	cylindromatosis I
	ubiquitin-specific-processing proteinase CYLD
	turban tumor syndrome protein
	2010013M14
	2900009M21
	C130039D01
	Cyld
	CYLD I
	FLJ20180
	cylindromatosis (turban tumor syndrome) gene
	cylindromatosis (turban tumor syndrome) protein
	cylindromatosis (turban tumour syndrome) gene
	cylindromatosis (turban tumour syndrome) protein
	cylindromatosis 1
	cylindromatosis gene
	cylindromatosis protein
	LOC100360670
	probable ubiquitin carboxyl-terminal hydrolase CYLD-like

EC Number	3.4.19.12

Mouse chromosome position	8

Rat chromosome position	19p11

Homologene ID	9069

MGI ID	1921506

RGD ID	1308346