Protein Birc3

URN	urn:agi-llid:330
Total Entities	0
Connectivity	545
Name	Birc3
Description	baculoviral IAP repeat-containing 3
Notes	The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.

Ariadne Ontology	IAP
	Secreted proteins

GO Molecular Function	metal ion binding
	zinc ion binding
	ligase activity
	ubiquitin-protein ligase activity

GO Biological Process	regulation of RIG-I signaling pathway
	regulation of nucleotide-binding oligomerization domain containing signaling pathway
	regulation of toll-like receptor signaling pathway
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	cell surface receptor signaling pathway
	NIK-NF-kappaB cascade
	negative regulation of reactive oxygen species metabolic process
	negative regulation of phosphorylation
	negative regulation of apoptotic process
	negative regulation of necroptosis
	regulation of apoptotic process
	protein ubiquitination
	apoptotic process
	necroptosis
	regulation of innate immune response
	regulation of inflammatory response
	regulation of cysteine-type endopeptidase activity
	spermatogenesis
	protein heterooligomerization

Pathway	Apoptosis
	FASLG Expression Targets
	CSF2/NF-kB Expression Targets
	TNF/NF-kB Expression Targets
	ripk2-Xiap
	tumor necrosis factor signaling pathway
	tumor necrosis factor mediated signaling pathway

Group	IAP
	regulation of RIG-I signaling pathway
	regulation of nucleotide-binding oligomerization domain containing signaling pathway
	regulation of toll-like receptor signaling pathway
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	cell surface receptor signaling pathway
	NIK-NF-kappaB cascade
	negative regulation of reactive oxygen species metabolic process
	negative regulation of phosphorylation
	negative regulation of apoptotic process
	negative regulation of necroptosis
	regulation of apoptotic process
	protein ubiquitination
	apoptotic process
	necroptosis
	regulation of innate immune response
	regulation of inflammatory response
	regulation of cysteine-type endopeptidase activity
	spermatogenesis
	protein heterooligomerization
	metal ion binding
	zinc ion binding
	ligase activity
	ubiquitin-protein ligase activity
	membrane raft
	protein complex
	intracellular
	cytoplasm
	nucleus
	Secreted proteins

MedScan ID	330

Hugo ID	591

Human chromosome position	11q22

Alias	AIP1
	API2
	MIHC
	CIAP2
	HAIP1
	HIAP1
	MALT2
	RNF49
	c-IAP2
	baculoviral IAP repeat-containing protein 3
	IAP-1
	IAP homolog C
	apoptosis inhibitor 2
	RING finger protein 49
	mammalian IAP homolog C
	inhibitor of apoptosis protein 1
	baculoviral IAP repeat-containing 3
	TNFR2-TRAF signaling complex protein
	TNFR2-TRAF-signaling complex protein 1
	Api1
	IAP1
	IAP2
	MIHB
	Birc2
	HIAP2
	MIAP1
	MIAP2
	cIAP1
	cIAP-1
	cIAP-2
	AW107670
	RP24-318P17.1
	mIAP-1
	apoptosis inhibitor 1
	baculoviral IAP repeat-containing 2
	TNFR2-TRAF signalling complex protein
	inhibitor of apoptosis 2
	inhibitor of apoptosis protein (IAP)2
	mcIAP I
	mcIAP1
	MGC93416
	inhibitor of apoptosis (cIAP)-2
	TNFR2-TRAF signaling complex protein I
	inhibitor of apoptosis II
	TNFR2-TRAF signaling complex protein 1
	AIP I
	baculoviral IAP repeat-containing III
	BIRC3
	HAIP I
	HIAP I
	apoptosis inhibitor II
	TNFR2-TRAF signaling complex protein 1
	TNFR2-TRAF signaling complex protein I
	mcIAP1s
	C-IAP2s
	RP24-318P17.2
	similar to apoptosis inhibitor I
	IAP I
	similar to apoptosis inhibitor 1
	mcIAP Is

OMIM ID	601721

EC Number	6.3.2.-

PIR ID	S68449

Cell Localization	Cytoplasm
	Nucleus

Mouse chromosome position	9
	9 A2

Rat chromosome position	8q11

Homologene ID	899

MGI ID	1197007

RGD ID	621282

Primary Cell Localization	Cytoplasm