| URN | urn:agi-llid:8772 |
|---|---|
| Total Entities | 0 |
| Connectivity | 509 |
| Name | Fadd |
| Description | Fas (TNFRSF6)-associated via death domain |
| Notes | an important adaptor molecule in apoptosis signaling; may mediate hepatocyte death [RGD] |
| Ariadne Ontology | TNFRAP |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | tumor necrosis factor receptor superfamily binding |
|---|---|
| tumor necrosis factor receptor binding | |
| death receptor binding | |
| protease binding |
| GO Cellular Component | membrane raft |
|---|---|
| death-inducing signaling complex | |
| CD95 death-inducing signaling complex | |
| protein complex | |
| cell body | |
| cytoplasm | |
| cytosol | |
| neuron projection |
| GO Biological Process | defense response to virus |
|---|---|
| virus-host interaction | |
| positive regulation of type I interferon-mediated signaling pathway | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of extrinsic apoptotic signaling pathway | |
| signal transduction | |
| apoptotic signaling pathway | |
| extrinsic apoptotic signaling pathway | |
| extrinsic apoptotic signaling pathway via death domain receptors | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of apoptotic process | |
| regulation of apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| cellular response to mechanical stimulus | |
| necrotic cell death | |
| apoptotic process | |
| innate immune response | |
| positive regulation of interleukin-8 production | |
| positive regulation of tumor necrosis factor production | |
| protein heterooligomerization |
| Pathway | Apoptosis |
|---|---|
| TNFRSF6 -> FOXO3A signaling | |
| FASLG Expression Targets | |
| Trail mediated signaling pathway | |
| FasL mediated signaling pathway | |
| Trail mediated signaling pathway | |
| FasL mediated signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | TNFRAP |
|---|---|
| defense response to virus | |
| virus-host interaction | |
| positive regulation of type I interferon-mediated signaling pathway | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of extrinsic apoptotic signaling pathway | |
| signal transduction | |
| apoptotic signaling pathway | |
| extrinsic apoptotic signaling pathway | |
| extrinsic apoptotic signaling pathway via death domain receptors | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of apoptotic process | |
| regulation of apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| cellular response to mechanical stimulus | |
| necrotic cell death | |
| apoptotic process | |
| innate immune response | |
| positive regulation of interleukin-8 production | |
| positive regulation of tumor necrosis factor production | |
| protein heterooligomerization | |
| tumor necrosis factor receptor superfamily binding | |
| tumor necrosis factor receptor binding | |
| death receptor binding | |
| protease binding | |
| membrane raft | |
| death-inducing signaling complex | |
| CD95 death-inducing signaling complex | |
| protein complex | |
| cell body | |
| cytoplasm | |
| cytosol | |
| neuron projection | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| MedScan ID | 8772 |
|---|
| Hugo ID | 3573 |
|---|
| Human chromosome position | 11q13.3 |
|---|
| LocusLink ID | 8772 |
|---|---|
| 14082 | |
| 266610 | |
| 493720 | |
| 562317 |
| Alias | GIG3 |
|---|---|
| MORT1 | |
| protein FADD | |
| growth-inhibiting gene 3 protein | |
| mediator of receptor induced toxicity | |
| mediator of receptor-induced toxicity | |
| Fas-associating protein with death domain | |
| Fas-associating death domain-containing protein | |
| Mort1/FADD | |
| FAS-associated death domain protein | |
| Fas-associated via death domain | |
| MGC8528 | |
| MORT I | |
| TNFRSF6-associated via death domain | |
| Fas-associated protein with death domain | |
| Fas (TNFRSF6)-associated via death domain | |
| FADD_HUMAN | |
| FADD | |
| Fas-associating protein | |
| chromosome | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 602457 |
|---|---|
| 613759 |
| Unigene ID | Hs.86131 |
|---|---|
| Mm.5126 | |
| Rn.16183 | |
| Bt.88785 | |
| Dr.94478 |
| KEGG ID | hsa:8772 |
|---|---|
| mmu:14082 | |
| rno:266610 |
| Swiss-Prot Accession | Q13158 |
|---|---|
| Q61160 | |
| Q8R2E7 | |
| Q3TC37 | |
| Q61082 | |
| Q14866 | |
| Q6IBR4 | |
| Q6LCB0 | |
| Q6LCG1 | |
| Q8CD57 |
| GO ID | 0005123 |
|---|---|
| 0002020 | |
| 0005164 | |
| 0032813 | |
| 0006919 | |
| 0008633 | |
| 0006915 | |
| 0071260 | |
| 0051607 | |
| 0097191 | |
| 0008625 | |
| 0045087 | |
| 0070265 | |
| 0043123 | |
| 0043065 | |
| 2001238 | |
| 0032757 | |
| 0045944 | |
| 0032760 | |
| 0060340 | |
| 0019048 | |
| 0031265 | |
| 0044297 | |
| 0005829 | |
| 0031264 | |
| 0045121 | |
| 0043005 | |
| 0051291 | |
| 0042981 | |
| 0007165 | |
| 0005737 | |
| 0043234 | |
| 0097190 | |
| 0008624 | |
| 0044419 | |
| 0042802 | |
| 0005794 | |
| 0005634 | |
| 0005515 | |
| 0004871 | |
| 0008632 | |
| 0007166 | |
| 0019735 | |
| 0019901 |
| PIR ID | A56912 |
|---|
| Swiss-Prot ID | FADD_MOUSE |
|---|---|
| FADD_HUMAN | |
| Q8R2E7_RAT |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00117888 |
|---|---|
| IPI00011919 | |
| IPI00198632 |
| Mouse chromosome position | 7 70.0 cM |
|---|
| Rat chromosome position | 1q42 |
|---|
| Homologene ID | 2836 |
|---|
| MGI ID | 109324 |
|---|
| RGD ID | 628700 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 11q13.3 |
|---|
| Microarray ID | 100500_at |
|---|
| FunctionalClass | death receptor binding |
|---|---|
| identical protein binding | |
| protein kinase binding | |
| signal transducer | |
| protein binding |
| Mus musculus Chromosome position | 7 70.0 cM |
|---|
| KEGG pathway | Apoptosis |
|---|---|
| Toll-like receptor signaling pathway |
| Rattus norvegicus Chromosome position | 1q42 |
|---|
| Bos taurus Chromosome position | 29 |
|---|