| URN | urn:agi-llid:6868 |
|---|---|
| Total Entities | 0 |
| Connectivity | 904 |
| Name | Adam17 |
| Description | a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) |
| Notes | expression occurs in response to oxygen glucose deprivation, may play a role in inhibition of apoptosis via induction of TNF-alpha release [RGD] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | integrin binding |
|---|---|
| interleukin-6 receptor binding | |
| SH3 domain binding | |
| PDZ domain binding | |
| metal ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| membrane raft | |
| apical plasma membrane | |
| integral to plasma membrane | |
| ruffle membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| cytoplasm | |
| actin cytoskeleton | |
| cell-cell junction | |
| focal adhesion |
| GO Biological Process | cell adhesion |
|---|---|
| positive regulation of cyclin-dependent protein kinase activity involved in G1-S | |
| positive regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of epidermal growth factor-activated receptor activity | |
| epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| integrin-mediated signaling pathway | |
| Notch signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| positive regulation of protein phosphorylation | |
| negative regulation of apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of cellular component movement | |
| positive regulation of cell migration | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of T cell chemotaxis | |
| regulation of mast cell apoptotic process | |
| B cell differentiation | |
| T cell differentiation in thymus | |
| cell adhesion mediated by integrin | |
| cell motility | |
| wound healing, spreading of epidermal cells | |
| neutrophil mediated immunity | |
| germinal center formation | |
| response to drug | |
| response to lipopolysaccharide | |
| response to high density lipoprotein particle stimulus | |
| response to hypoxia | |
| negative regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| spleen development | |
| proteolysis | |
| membrane protein ectodomain proteolysis | |
| membrane protein intracellular domain proteolysis | |
| PMA-inducible membrane protein ectodomain proteolysis |
| Pathway | Notch -> LEF1 signaling |
|---|---|
| Notch -> MEF/MYOD signaling | |
| Notch -> NF-kB signaling | |
| Notch -> RBPJ/HES/HEY signaling | |
| Notch -> SMAD3 signaling | |
| Notch -> EP300/ASCL signaling | |
| Notch -> TCF3 signaling | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| ADAM17 Expression Targets | |
| Interleukin-6 signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway | |
| interleukin-6 signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | cell adhesion |
|---|---|
| positive regulation of cyclin-dependent protein kinase activity involved in G1-S | |
| positive regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of epidermal growth factor-activated receptor activity | |
| epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| integrin-mediated signaling pathway | |
| Notch signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| positive regulation of protein phosphorylation | |
| negative regulation of apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of cellular component movement | |
| positive regulation of cell migration | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of T cell chemotaxis | |
| regulation of mast cell apoptotic process | |
| B cell differentiation | |
| T cell differentiation in thymus | |
| cell adhesion mediated by integrin | |
| cell motility | |
| wound healing, spreading of epidermal cells | |
| neutrophil mediated immunity | |
| germinal center formation | |
| response to drug | |
| response to lipopolysaccharide | |
| response to high density lipoprotein particle stimulus | |
| response to hypoxia | |
| negative regulation of interleukin-8 production | |
| positive regulation of chemokine production | |
| spleen development | |
| proteolysis | |
| membrane protein ectodomain proteolysis | |
| membrane protein intracellular domain proteolysis | |
| PMA-inducible membrane protein ectodomain proteolysis | |
| integrin binding | |
| interleukin-6 receptor binding | |
| SH3 domain binding | |
| PDZ domain binding | |
| metal ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity | |
| membrane | |
| extracellular region | |
| membrane raft | |
| apical plasma membrane | |
| integral to plasma membrane | |
| ruffle membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| cytoplasm | |
| actin cytoskeleton | |
| cell-cell junction | |
| focal adhesion | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 6868 |
|---|
| Hugo ID | 195 |
|---|
| Human chromosome position | 2p25 |
|---|
| LocusLink ID | 6868 |
|---|---|
| 11491 | |
| 57027 | |
| 517541 | |
| 560657 |
| Alias | CSVP |
|---|---|
| TACE | |
| NISBD | |
| ADAM18 | |
| CD156B | |
| disintegrin and metalloproteinase domain-containing protein 17 | |
| TNF-alpha convertase | |
| snake venom-like protease | |
| TNF-alpha converting enzyme | |
| ADAM metallopeptidase domain 18 | |
| tumor necrosis factor, alpha, converting enzyme | |
| ADAM 17 | |
| TNF-alpha-converting enzyme | |
| a disintegrin and metalloproteinase domain 17 | |
| a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme | |
| a disintegrin and metalloprotease domain 17 | |
| a disintegrin and metallopeptidase domain 17 | |
| a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) | |
| disintegrin and metalloproteinase domain 17 | |
| MGC71942 | |
| disintegrin and metalloproteinase domain 17 isoform 2 preproprotein | |
| disintegrin and metalloprotease domain-containing protein 17 | |
| LOC129645 | |
| LOC236174 | |
| disintegrin and metalloproteinase domain 17 isoform 1 preproprotein | |
| OTTMUSP00000023111 | |
| tumour necrosis factor, alpha, converting enzyme | |
| disintegrin and metalloprotease domain 17 isoform 2 preproprotein | |
| a disintegrin and metalloprotease domain 17 isoform 2 preproprotein | |
| Snake venom-like proteinase | |
| a disintegrin and metalloprotease domain 17 (tumour necrosis factor, alpha, converting enzyme) | |
| a disintegrin and metalloprotease domain 17 (tumor necrosis factor, alpha, converting enzyme) | |
| disintegrin and metalloprotease domain 17 isoform 1 preproprotein | |
| a disintegrin and metalloprotease domain 17 isoform 1 preproprotein | |
| a disintegrin and metalloproteinase domain 17 isoform 1 preproprotein | |
| a disintegrin and metalloproteinase domain 17 isoform 2 preproprotein | |
| a disintegrin and metalloproteinase domain 17; TNF-alpha converting enzyme | |
| ADAM metallopeptidase domain 17 | |
| Adam17 | |
| disintegrin and metalloprotease domain 17 | |
| a disintegrin and metalloproteinase domain 17 (tumour necrosis factor, alpha, converting enzyme) | |
| A disintegrin and metalloproteinase domain 17 | |
| a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme precursor | |
| Adam17s | |
| TNF-alpha converting enzyme precursor | |
| DKEY-81B15.2 | |
| a disintegrin and metallopeptidase domain 17b | |
| adam17b | |
| chromosome | |
| scaffold | |
| si:dkey-81b15.2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 603639 |
|---|---|
| 614328 |
| Unigene ID | Hs.404914 |
|---|---|
| Mm.27681 | |
| Rn.144585 | |
| Bt.35787 | |
| Dr.93496 |
| KEGG ID | hsa:6868 |
|---|---|
| mmu:11491 | |
| rno:57027 |
| Swiss-Prot Accession | B2RNB2 |
|---|---|
| P78536 | |
| Q3UEW9 | |
| Q9Z0F8 | |
| Q9Z1K9 | |
| O88726 | |
| Q505A7 | |
| Q9R1U4 | |
| Q9Z0K3 | |
| O60226 | |
| Q53RF5 | |
| Q53RS1 | |
| Q53S40 | |
| Q6P5T8 | |
| Q3TMS9 | |
| Q3UEC0 | |
| Q3UNK7 | |
| Q3UV09 |
| EC Number | 3.4.24.86 |
|---|
| GO ID | 0030165 |
|---|---|
| 0017124 | |
| 0005178 | |
| 0005138 | |
| 0004222 | |
| 0008237 | |
| 0008270 | |
| 0030183 | |
| 0060397 | |
| 0007219 | |
| 0051088 | |
| 0033077 | |
| 0007155 | |
| 0033627 | |
| 0048870 | |
| 0007173 | |
| 0035625 | |
| 0002467 | |
| 0006509 | |
| 0031293 | |
| 0032717 | |
| 0048011 | |
| 0002446 | |
| 0010820 | |
| 0030307 | |
| 0030335 | |
| 0008284 | |
| 0051272 | |
| 0032722 | |
| 0031659 | |
| 0045741 | |
| 0002690 | |
| 0001934 | |
| 0030511 | |
| 0033025 | |
| 0042493 | |
| 0055099 | |
| 0001666 | |
| 0032496 | |
| 0048536 | |
| 0035313 | |
| 0015629 | |
| 0016324 | |
| 0009986 | |
| 0005911 | |
| 0005737 | |
| 0005925 | |
| 0005887 | |
| 0045121 | |
| 0005886 | |
| 0032587 | |
| 0016787 | |
| 0046872 | |
| 0008233 | |
| 0007229 | |
| 0043066 | |
| 0006508 | |
| 0005576 | |
| 0016021 | |
| 0016020 | |
| 0006916 | |
| 0009617 | |
| 0005515 | |
| 0005578 | |
| 0007267 | |
| 0016485 | |
| 0016337 | |
| 0001726 | |
| 0005615 | |
| 0004872 |
| Swiss-Prot ID | ADA17_RAT |
|---|---|
| ADA17_MOUSE | |
| ADA17_HUMAN | |
| Q505A7_MOUSE | |
| Q3UEW9_MOUSE | |
| B2RNB2_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Secreted | |
| Extracellular |
| IPI ID | IPI00208963 |
|---|---|
| IPI00381630 | |
| IPI00762180 | |
| IPI00029606 | |
| IPI00288894 | |
| IPI00654169 | |
| IPI00314443 | |
| IPI00563637 |
| Mouse chromosome position | 12 3.0 cM |
|---|
| Rat chromosome position | 6q16 |
|---|
| Homologene ID | 2395 |
|---|
| MGI ID | 1096335 |
|---|
| RGD ID | 620404 |
|---|
| LocatorString | pmquery:egfr+transactivation |
|---|
| Homo sapiens Chromosome position | 2p25 |
|---|
| Microarray ID | 160241_at |
|---|---|
| 1421858_at |
| FunctionalClass | metal ion binding |
|---|---|
| metalloendopeptidase | |
| protein binding | |
| zinc ion binding | |
| hydrolase | |
| metallopeptidase | |
| peptidase | |
| receptor | |
| integrin binding |
| Mus musculus Chromosome position | 12 3.0 cM |
|---|
| KEGG pathway | Notch signaling pathway |
|---|
| Rattus norvegicus Chromosome position | 6q16 |
|---|
| Bos taurus Chromosome position | 11 |
|---|