| URN | urn:agi-llid:7132 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1495 |
| Name | Tnfrsf1a |
| Description | tumor necrosis factor receptor superfamily, member 1a |
| Notes | may play a role in TNFalpha mediated inflammatory response to spinal cord injury [RGD] |
| Ariadne Ontology | TNFR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein complex binding |
|---|---|
| protease binding | |
| tumor necrosis factor binding | |
| tumor necrosis factor-activated receptor activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| membrane raft | |
| integral to plasma membrane | |
| integral to membrane | |
| protein complex | |
| plasma membrane | |
| cell surface | |
| nucleus | |
| axon | |
| extracellular space |
| GO Biological Process | defense response to bacterium |
|---|---|
| virus-host interaction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of tyrosine phosphorylation of Stat1 protein | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| apoptotic signaling pathway | |
| cytokine-mediated signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein import into nucleus, translocation | |
| regulation of apoptotic process | |
| tetrapyrrole metabolic process | |
| flavonoid metabolic process | |
| diterpenoid metabolic process | |
| cellular response to estradiol stimulus | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| response to amino acid stimulus | |
| response to lipopolysaccharide | |
| response to alkaloid | |
| response to ethanol | |
| defense response | |
| response to hypoxia | |
| response to wounding | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| negative regulation of inflammatory response | |
| negative regulation of interleukin-6 production | |
| negative regulation of gene expression | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of angiogenesis | |
| positive regulation of gene expression | |
| prostaglandin metabolic process | |
| protein heterooligomerization |
| Pathway | Apoptosis |
|---|---|
| TNFR -> NF-kB signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TNFRSF1A -> STAT signaling | |
| LTA Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/STAT Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| IL2 Expression Targets | |
| IFNG-IFNR Expression Targets | |
| CXCL12 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| CSF1/STAT Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| Dopamine/Gs Expression Targets | |
| FSHR Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| IL1B/NO Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| TNF/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | TNFR |
|---|---|
| defense response to bacterium | |
| virus-host interaction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of tyrosine phosphorylation of Stat1 protein | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| apoptotic signaling pathway | |
| cytokine-mediated signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein import into nucleus, translocation | |
| regulation of apoptotic process | |
| tetrapyrrole metabolic process | |
| flavonoid metabolic process | |
| diterpenoid metabolic process | |
| cellular response to estradiol stimulus | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| response to amino acid stimulus | |
| response to lipopolysaccharide | |
| response to alkaloid | |
| response to ethanol | |
| defense response | |
| response to hypoxia | |
| response to wounding | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| negative regulation of inflammatory response | |
| negative regulation of interleukin-6 production | |
| negative regulation of gene expression | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of angiogenesis | |
| positive regulation of gene expression | |
| prostaglandin metabolic process | |
| protein heterooligomerization | |
| protein complex binding | |
| protease binding | |
| tumor necrosis factor binding | |
| tumor necrosis factor-activated receptor activity | |
| membrane | |
| extracellular region | |
| membrane raft | |
| integral to plasma membrane | |
| integral to membrane | |
| protein complex | |
| plasma membrane | |
| cell surface | |
| nucleus | |
| axon | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| MedScan ID | 7132 |
|---|
| Hugo ID | 11916 |
|---|
| Human chromosome position | 12p13.2 |
|---|
| LocusLink ID | 7132 |
|---|---|
| 21937 | |
| 25625 | |
| 8077 | |
| 282527 | |
| 406471 |
| Alias | FPF |
|---|---|
| MS5 | |
| p55 | |
| p60 | |
| TBP1 | |
| TNF-R | |
| TNFAR | |
| TNFR1 | |
| p55-R | |
| CD120a | |
| TNFR55 | |
| TNFR60 | |
| TNF-R-I | |
| TNF-R55 | |
| TNFR1-d2 | |
| tumor necrosis factor receptor superfamily member 1A | |
| TNF-R1 | |
| TNF-RI | |
| TNFR-I | |
| tumor necrosis factor-alpha receptor | |
| tumor necrosis factor receptor type 1 | |
| tumor necrosis factor binding protein 1 | |
| tumor necrosis factor receptor 1A isoform beta | |
| TNFRI | |
| Tnfr-2 | |
| TNFRp55 | |
| TNF-alphaR1 | |
| TNFalpha-R1 | |
| TNF-alpha-R1 | |
| TNF receptor alpha chain | |
| tumor necrosis factor receptor 1 | |
| tumor necrosis factor receptor type I | |
| TNF receptor 1A | |
| TNF receptor homolog 3 | |
| TNF receptor homolog III | |
| TNF receptors | |
| TNF receptor 1 | |
| LOC113298 | |
| TNFR I | |
| TNF receptor | |
| TBPI | |
| OTTMUSP00000028139 | |
| MGC19588 | |
| LOC116290 | |
| GNB:339760 | |
| Familial periodic fever (Hibernian fever) gene | |
| MGC105478 | |
| tumour necrosis factor receptor 1 (55kD) | |
| tumor necrosis factor TNF receptor | |
| tumor necrosis factor TNF receptors | |
| tumor necrosis factor, alpha receptors | |
| tumor necrosis factor receptor superfamily, member 1A | |
| tumour necrosis factor binding protein I | |
| tumour necrosis factor receptor 1 | |
| tumour necrosis factor receptor type I | |
| tumour necrosis factor TNF receptor | |
| tumour necrosis factor TNF receptors | |
| tumour necrosis factor, alpha receptors | |
| tumour necrosis factor-alpha receptor | |
| tumour necrosis factor binding protein 1 | |
| tumour necrosis factor receptor superfamily, member 1A | |
| Tnfrh3 | |
| Tumor necrosis factor binding protein I | |
| tumor necrosis factor receptor 1 (55kD) | |
| Tnfrsf1a | |
| TRAPS | |
| TR1A_HUMAN | |
| TR1A | |
| Tumor necrosis factor receptor 1 precursor | |
| TNF-R1s | |
| TNFR60s | |
| TNFR55s | |
| Tnfrh3s | |
| Tumor necrosis factor binding protein 1 | |
| Tumor necrosis factor binding protein I | |
| TNF-R-Is | |
| LOC406471 | |
| chromosome | |
| scaffold | |
| wu:fj65b10 | |
| zgc:85914 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 191190 |
|---|---|
| 614810 | |
| 142680 |
| Unigene ID | Hs.279594 |
|---|---|
| Mm.1258 | |
| Mm.474976 | |
| Rn.11119 | |
| Hs.713833 | |
| Hs.707975 | |
| Mm.471265 | |
| Bt.3890 | |
| Dr.27758 | |
| Mm.466360 |
| KEGG ID | hsa:7132 |
|---|---|
| mmu:21937 | |
| rno:25625 |
| Swiss-Prot Accession | P19438 |
|---|---|
| P25118 | |
| Q3U479 | |
| P22934 | |
| Q5U1X6 | |
| Q91V30 | |
| Q91Y93 | |
| A8K4X3 | |
| B2RDE4 | |
| B3KPQ1 | |
| B4DQB7 | |
| B4E309 | |
| D3DUR1 | |
| Q9UCA4 | |
| Q6Y4Q7 | |
| Q3TVS9 | |
| Q4VAE0 | |
| Q6QHF0 | |
| Q6QHF1 |
| GO ID | 0002020 |
|---|---|
| 0043120 | |
| 0005031 | |
| 0006915 | |
| 0071392 | |
| 0071260 | |
| 0019221 | |
| 0042742 | |
| 0016101 | |
| 0009812 | |
| 0006954 | |
| 0010629 | |
| 0050728 | |
| 0032715 | |
| 0043123 | |
| 0045766 | |
| 0050729 | |
| 0033160 | |
| 0045944 | |
| 0032760 | |
| 0042511 | |
| 0006693 | |
| 0042981 | |
| 0043279 | |
| 0043200 | |
| 0045471 | |
| 0001666 | |
| 0032496 | |
| 0033013 | |
| 0019048 | |
| 0030424 | |
| 0009986 | |
| 0005576 | |
| 0005615 | |
| 0005887 | |
| 0045121 | |
| 0005634 | |
| 0005886 | |
| 0043234 | |
| 0032403 | |
| 0007166 | |
| 0006952 | |
| 0010628 | |
| 0051291 | |
| 0007165 | |
| 0033209 | |
| 0016021 | |
| 0016020 | |
| 0009611 | |
| 0008624 | |
| 0004872 | |
| 0044419 | |
| 0005515 | |
| 0009055 | |
| 0020037 | |
| 0005164 | |
| 0019899 | |
| 0000187 | |
| 0008219 | |
| 0005489 | |
| 0006118 | |
| 0007242 | |
| 0051536 |
| PIR ID | B36555 |
|---|---|
| A38208 | |
| A38634 |
| Swiss-Prot ID | TNR1A_RAT |
|---|---|
| TNR1A_HUMAN | |
| TNR1A_MOUSE | |
| D3DUR1_HUMAN | |
| Q3U479_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Secreted | |
| Plasma membrane |
| IPI ID | IPI00212001 |
|---|---|
| IPI00018880 | |
| IPI00795875 | |
| IPI00929211 | |
| IPI00317228 | |
| IPI00796532 | |
| IPI00794282 | |
| IPI00607905 | |
| IPI00856824 | |
| IPI00886384 | |
| IPI00857089 | |
| IPI00568944 |
| Mouse chromosome position | 6 60.55 cM |
|---|
| Rat chromosome position | 4q42 |
|---|
| Homologene ID | 828 |
|---|
| MGI ID | 1314884 |
|---|
| RGD ID | 621237 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|
| Homo sapiens Chromosome position | 12p13.2 |
|---|---|
| 12p13 |
| Microarray ID | 161194_r_at |
|---|---|
| 92793_at |
| FunctionalClass | protein binding |
|---|---|
| receptor | |
| tumor necrosis factor receptor | |
| electron carrier | |
| heme binding | |
| enzyme binding | |
| electron transporter | |
| tumor necrosis factor receptor binding | |
| iron-sulfur cluster binding | |
| protein complex binding |
| Mus musculus Chromosome position | 6 60.55 cM |
|---|
| KEGG pathway | Apoptosis |
|---|---|
| Cytokine-cytokine receptor interaction | |
| MAPK signaling pathway | |
| Adipocytokine signaling pathway |
| Rattus norvegicus Chromosome position | 4q42 |
|---|
| Bos taurus Chromosome position | 5 |
|---|