| URN | urn:agi-llid:841 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1814 |
| Name | Casp8 |
| Description | caspase 8, apoptosis-related cysteine peptidase |
| Notes | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq] |
| Ariadne Ontology | CASP8-10 |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | tumor necrosis factor receptor binding |
|---|---|
| protease binding | |
| hydrolase activity | |
| peptidase activity | |
| cysteine-type peptidase activity | |
| cysteine-type endopeptidase activity |
| GO Cellular Component | mitochondrial outer membrane |
|---|---|
| nucleolus | |
| Noc1p-Noc2p complex | |
| centrosome | |
| membrane raft | |
| death-inducing signaling complex | |
| CD95 death-inducing signaling complex | |
| protein complex | |
| cell body | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| cytoskeleton | |
| nucleus | |
| neuron projection |
| GO Biological Process | metabolic process |
|---|---|
| virus-host interaction | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| apoptotic signaling pathway | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| extrinsic apoptotic signaling pathway | |
| positive regulation of macrophage differentiation | |
| regulation of apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| macrophage differentiation | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| cellular component disassembly involved in execution phase of apoptosis | |
| innate immune response | |
| response to cobalt ion | |
| response to lipopolysaccharide | |
| response to estradiol stimulus | |
| response to ethanol | |
| response to tumor necrosis factor | |
| response to antibiotic | |
| response to cold | |
| angiogenesis | |
| neural tube formation | |
| heart development | |
| proteolysis | |
| proteolysis involved in cellular protein catabolic process | |
| protein heterooligomerization |
| Pathway | Apoptosis |
|---|---|
| TNFRSF6 -> FOXO3A signaling | |
| Doxorubicin-Induced Cardiotoxicity | |
| FASLG Expression Targets | |
| IL6 Expression Targets | |
| IFNG-IFNR Expression Targets | |
| CD80/STAT Expression Targets | |
| titanium dioxide nanoparticle response pathway | |
| Trail mediated signaling pathway | |
| FasL mediated signaling pathway | |
| Trail mediated signaling pathway | |
| FasL mediated signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | CASP8-10 |
|---|---|
| metabolic process | |
| virus-host interaction | |
| negative regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| apoptotic signaling pathway | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| extrinsic apoptotic signaling pathway | |
| positive regulation of macrophage differentiation | |
| regulation of apoptotic process | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| macrophage differentiation | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| cellular component disassembly involved in execution phase of apoptosis | |
| innate immune response | |
| response to cobalt ion | |
| response to lipopolysaccharide | |
| response to estradiol stimulus | |
| response to ethanol | |
| response to tumor necrosis factor | |
| response to antibiotic | |
| response to cold | |
| angiogenesis | |
| neural tube formation | |
| heart development | |
| proteolysis | |
| proteolysis involved in cellular protein catabolic process | |
| protein heterooligomerization | |
| tumor necrosis factor receptor binding | |
| protease binding | |
| hydrolase activity | |
| peptidase activity | |
| cysteine-type peptidase activity | |
| cysteine-type endopeptidase activity | |
| mitochondrial outer membrane | |
| nucleolus | |
| Noc1p-Noc2p complex | |
| centrosome | |
| membrane raft | |
| death-inducing signaling complex | |
| CD95 death-inducing signaling complex | |
| protein complex | |
| cell body | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| cytoskeleton | |
| nucleus | |
| neuron projection | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 841 |
|---|
| Hugo ID | 1509 |
|---|
| Human chromosome position | 2q33-q34 |
|---|
| LocusLink ID | 841 |
|---|---|
| 12370 | |
| 64044 |
| Alias | CAP4 |
|---|---|
| MACH | |
| MCH5 | |
| FLICE | |
| ALPS2B | |
| Casp-8 | |
| caspase-8 | |
| FADD-like ICE | |
| MACH-alpha-1/2/3 protein | |
| apoptotic protease Mch-5 | |
| MACH-beta-1/2/3/4 protein | |
| apoptotic cysteine protease | |
| ICE-like apoptotic protease 5 | |
| MORT1-associated ced-3 homolog | |
| FADD-homologous ICE/CED-3-like protease | |
| caspase 8, apoptosis-related cysteine protease | |
| Fas-linked ICE-like protease | |
| FLICE/MACH1 | |
| LOC116239 | |
| ICE-like apoptotic proteinase V | |
| ICE-like apoptotic proteinase 5 | |
| ICE-like apoptotic protease V | |
| FLJ17672 | |
| OTTHUMP00000206581 | |
| MGC78473 | |
| OTTHUMP00000163718 | |
| OTTHUMP00000163719 | |
| OTTHUMP00000163720 | |
| OTTHUMP00000206557 | |
| caspase 8 isoform D | |
| Pro- Casp8 | |
| procaspase 8 | |
| OTTHUMP00000165063 | |
| caspase 8 isoform B | |
| procaspase 8L | |
| ALPS2B gene | |
| Apoptotic protease Mch V | |
| Apoptotic proteinase Mch V | |
| Apoptotic proteinase Mch-5 | |
| Casp8 | |
| caspase 8, apoptosis-related cysteine peptidase | |
| caspase 8 isoform A | |
| Fas-linked ICE-like proteinase | |
| caspase 8 isoform C | |
| caspase 8 isoform E | |
| caspase 8, apoptosis-related cysteine proteinase | |
| caspase VIII | |
| FADD-homologous ICE/CED-3-like proteinase | |
| caspase 8 | |
| Mch5 isoform alpha | |
| procaspase-8 | |
| cysteine protease |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601763 |
|---|---|
| 607271 | |
| 114480 | |
| 114550 | |
| 211980 |
| Unigene ID | Hs.599762 |
|---|---|
| Mm.336851 | |
| Rn.54474 |
| KEGG ID | hsa:841 |
|---|---|
| mmu:12370 | |
| rno:64044 |
| Swiss-Prot Accession | Q14790 |
|---|---|
| O89110 | |
| Q3U607 | |
| Q9JHX4 | |
| O35669 | |
| O14676 | |
| Q14791 | |
| Q14792 | |
| Q14793 | |
| Q14794 | |
| Q14795 | |
| Q14796 | |
| Q15780 | |
| Q15806 | |
| Q53TT5 | |
| Q8TDI1 | |
| Q8TDI2 | |
| Q8TDI3 | |
| Q8TDI4 | |
| Q8TDI5 | |
| Q96T22 | |
| Q9C0K4 | |
| Q9UQ81 | |
| Q6NVI2 | |
| Q9HBU4 | |
| Q4FK85 |
| EC Number | 3.4.22.61 |
|---|
| GO ID | 0004197 |
|---|---|
| 0008234 | |
| 0002020 | |
| 0005164 | |
| 0006919 | |
| 0008633 | |
| 0001525 | |
| 0006915 | |
| 0006921 | |
| 0071260 | |
| 0097191 | |
| 0007507 | |
| 0045087 | |
| 0030225 | |
| 0043124 | |
| 0001841 | |
| 0035872 | |
| 0070423 | |
| 0043123 | |
| 0045651 | |
| 0051291 | |
| 0006508 | |
| 0051603 | |
| 0046677 | |
| 0032025 | |
| 0009409 | |
| 0032355 | |
| 0045471 | |
| 0032496 | |
| 0034612 | |
| 0019048 | |
| 0031265 | |
| 0030690 | |
| 0044297 | |
| 0005813 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0031264 | |
| 0045121 | |
| 0005741 | |
| 0005739 | |
| 0043005 | |
| 0005730 | |
| 0005634 | |
| 0016787 | |
| 0008233 | |
| 0008152 | |
| 0042981 | |
| 0043234 | |
| 0097190 | |
| 0008624 | |
| 0042802 | |
| 0005515 |
| Swiss-Prot ID | CASP8_MOUSE |
|---|---|
| CASP8_HUMAN | |
| Q3U607_MOUSE | |
| Q9JHX4_RAT |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00131533 |
|---|---|
| IPI00000149 | |
| IPI00073318 | |
| IPI00220721 | |
| IPI00220722 | |
| IPI00220723 | |
| IPI00220724 | |
| IPI00220725 | |
| IPI00220726 | |
| IPI00305242 | |
| IPI00793235 | |
| IPI00200025 | |
| IPI00816480 | |
| IPI00389465 |
| Mouse chromosome position | 1 30.1 cM |
|---|
| Rat chromosome position | 9q31 |
|---|
| Homologene ID | 7657 |
|---|
| MGI ID | 1261423 |
|---|
| RGD ID | 620945 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|