| URN | urn:agi-llid:7124 |
|---|---|
| Total Entities | 0 |
| Connectivity | 11145 |
| Name | Tnf |
| Description | tumor necrosis factor (TNF superfamily, member 2) |
| Notes | acts as a cytokine; binds TNF receptors; plays a role in regulation of cell proliferation, induction of apoptosis, and inflammatory response [RGD] |
| Ariadne Ontology | TNF family |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | cytokine activity |
|---|---|
| tumor necrosis factor receptor binding | |
| protease binding | |
| transcription regulatory region DNA binding |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| membrane raft | |
| phagocytic cup | |
| external side of plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| intracellular | |
| recycling endosome | |
| secretory granule | |
| extracellular space |
| GO Biological Process | cell proliferation |
|---|---|
| response to virus | |
| defense response to bacterium | |
| defense response to Gram-positive bacterium | |
| negative regulation of growth of symbiont in host | |
| negative regulation of viral genome replication | |
| cell activation | |
| positive regulation of mitosis | |
| positive regulation of synaptic transmission | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of JNK cascade | |
| regulation of I-kappaB kinase-NF-kappaB cascade | |
| activation of MAPKKK activity | |
| positive regulation of MAP kinase activity | |
| activation of MAPK activity | |
| positive regulation of NF-kappaB import into nucleus | |
| regulation of insulin secretion | |
| signal transduction | |
| regulation of cell proliferation | |
| apoptotic signaling pathway | |
| MAPK cascade | |
| protein kinase B signaling cascade | |
| JNK cascade | |
| calcium-mediated signaling | |
| lipopolysaccharide-mediated signaling pathway | |
| extrinsic apoptotic signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| extrinsic apoptotic signaling pathway via death domain receptors | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of vitamin D biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of translational initiation by iron | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of protein phosphorylation | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of alkaline phosphatase activity | |
| negative regulation of cell proliferation | |
| negative regulation of fat cell differentiation | |
| negative regulation of osteoblast differentiation | |
| negative regulation of apoptotic process | |
| negative regulation of cytokine secretion involved in immune response | |
| positive regulation of cell proliferation | |
| positive regulation of protein localization to cell surface | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of mononuclear cell migration | |
| positive regulation of osteoclast differentiation | |
| positive regulation of heterotypic cell-cell adhesion | |
| positive regulation of necrotic cell death | |
| positive regulation of programmed cell death | |
| induction of necroptosis by extracellular signals | |
| positive regulation of apoptotic process | |
| induction of apoptosis | |
| positive regulation of neuron apoptotic process | |
| positive regulation of NFAT protein import into nucleus | |
| positive regulation of cytokine secretion | |
| regulation of protein secretion | |
| regulation of immunoglobulin secretion | |
| regulation of osteoclast differentiation | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| osteoclast differentiation | |
| receptor biosynthetic process | |
| leukocyte tethering or rolling | |
| leukocyte migration | |
| cellular extravasation | |
| cellular response to organic cyclic compound | |
| cellular response to nicotine | |
| cellular response to amino acid stimulus | |
| necrotic cell death | |
| apoptotic process | |
| transformed cell apoptotic process | |
| extracellular matrix organization | |
| immune response | |
| positive regulation of humoral immune response mediated by circulating immunoglobulin | |
| humoral immune response | |
| positive regulation of chronic inflammatory response to antigenic stimulus | |
| chronic inflammatory response to antigenic stimulus | |
| epithelial cell proliferation involved in salivary gland morphogenesis | |
| response to activity | |
| response to drug | |
| response to glucocorticoid stimulus | |
| defense response | |
| response to hypoxia | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| positive regulation of fever generation | |
| response to salt stress | |
| response to mechanical stimulus | |
| negative regulation of lipid storage | |
| negative regulation of branching involved in lung morphogenesis | |
| negative regulation of interleukin-6 production | |
| negative regulation of gene expression | |
| negative regulation of lipid catabolic process | |
| negative regulation of L-glutamate transport | |
| negative regulation of glucose import | |
| positive regulation of protein complex assembly | |
| positive regulation of podosome assembly | |
| positive regulation of protein complex disassembly | |
| positive regulation of cytokine production | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| positive regulation of interferon-gamma production | |
| positive regulation of interleukin-18 production | |
| positive regulation of chemokine (C-X-C motif) ligand 2 production | |
| positive regulation of hair follicle development | |
| regulation of branching involved in salivary gland morphogenesis | |
| positive regulation of protein transport | |
| positive regulation of calcidiol 1-monooxygenase activity | |
| multicellular organismal development | |
| embryonic digestive tract development | |
| organ morphogenesis | |
| skeletal muscle contraction | |
| protein import into nucleus, translocation | |
| glucose metabolic process | |
| sequestering of triglyceride |
| Pathway | Apoptosis |
|---|---|
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> AP-1/ATF/TP53 signaling | |
| TNFRSF1A -> CREB/ELK-SRF signaling | |
| TNFRSF1A -> STAT signaling | |
| ROS in Triggering Vascular Inflammation | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| TLR3 Expression Targets | |
| TGFB2-TGFBR1 Expression Targets | |
| ADAM17 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/STAT Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| TNF/ELK-SRF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| CD40LG/STAT Expression Targets | |
| Fibronectin Expression Targets | |
| CD21 Expression Targets | |
| FCGR3A Expression Targets | |
| IL13 Expression Targets | |
| IL21 Expression Targets | |
| IL15 Expression Targets | |
| IL7 Expression Targets | |
| IL2 Expression Targets | |
| IL4 Expression Targets | |
| IL3 Expression Targets | |
| CTF1 Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| PRL-PRLR Expression Targets | |
| CSF2/NF-kB Expression Targets | |
| IFNG-IFNR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| CCL4 Expression Targets | |
| CCL16 Expression Targets | |
| CCL15 Expression Targets | |
| CXCL12 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| S100B Expression Targets | |
| HMGB1 Expression Targets | |
| Acetylcholine Expression Targets | |
| TGFA/CTNNB/CTNND Expression Targets | |
| TGFA/STAT Expression Targets | |
| TGFA/MEF/MYOD/NFATC Expression Targets | |
| KITLG/STAT Expression Targets | |
| Collagen/NF-kB Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| GAS6/AP-1/CREB Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/FOXO3A Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| Thromboxane A2 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| Adenosine Expression Targets | |
| Glutamate/Gq Expression Targets | |
| Morphine Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| NTS Expression Targets | |
| S1P Expression Targets | |
| TAC1 Expression Targets | |
| Epinephrine/Gs Expression Targets | |
| Noradrenaline/Gs Expression Targets | |
| VIP Expression Targets | |
| Dopamine/Gs Expression Targets | |
| GCG Expression Targets | |
| FSHR Expression Targets | |
| POMC Expression Targets | |
| IFNA1/Gq Expression Targets | |
| EDN3 Expression Targets | |
| ADCYAP1 Expression Targets | |
| CD2 Expression Targets | |
| IL16/AP-1 Expression Targets | |
| CD8/STAT Expression Targets | |
| CD8/NF-kB Expression Targets | |
| CD8/NFATC Expression Targets | |
| CD8/AP-1 Expression Targets | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| TCR/AP-1 Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| IL1B/NO Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| TCR/NFAT Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway | |
| ripk2-Xiap | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | TNF family |
|---|---|
| cell proliferation | |
| response to virus | |
| defense response to bacterium | |
| defense response to Gram-positive bacterium | |
| negative regulation of growth of symbiont in host | |
| negative regulation of viral genome replication | |
| cell activation | |
| positive regulation of mitosis | |
| positive regulation of synaptic transmission | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of JNK cascade | |
| regulation of I-kappaB kinase-NF-kappaB cascade | |
| activation of MAPKKK activity | |
| positive regulation of MAP kinase activity | |
| activation of MAPK activity | |
| positive regulation of NF-kappaB import into nucleus | |
| regulation of insulin secretion | |
| signal transduction | |
| regulation of cell proliferation | |
| apoptotic signaling pathway | |
| MAPK cascade | |
| protein kinase B signaling cascade | |
| JNK cascade | |
| calcium-mediated signaling | |
| lipopolysaccharide-mediated signaling pathway | |
| extrinsic apoptotic signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| extrinsic apoptotic signaling pathway via death domain receptors | |
| positive regulation of membrane protein ectodomain proteolysis | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of vitamin D biosynthetic process | |
| positive regulation of interleukin-8 biosynthetic process | |
| positive regulation of chemokine biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of translational initiation by iron | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of protein phosphorylation | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of alkaline phosphatase activity | |
| negative regulation of cell proliferation | |
| negative regulation of fat cell differentiation | |
| negative regulation of osteoblast differentiation | |
| negative regulation of apoptotic process | |
| negative regulation of cytokine secretion involved in immune response | |
| positive regulation of cell proliferation | |
| positive regulation of protein localization to cell surface | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of mononuclear cell migration | |
| positive regulation of osteoclast differentiation | |
| positive regulation of heterotypic cell-cell adhesion | |
| positive regulation of necrotic cell death | |
| positive regulation of programmed cell death | |
| induction of necroptosis by extracellular signals | |
| positive regulation of apoptotic process | |
| induction of apoptosis | |
| positive regulation of neuron apoptotic process | |
| positive regulation of NFAT protein import into nucleus | |
| positive regulation of cytokine secretion | |
| regulation of protein secretion | |
| regulation of immunoglobulin secretion | |
| regulation of osteoclast differentiation | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| osteoclast differentiation | |
| receptor biosynthetic process | |
| leukocyte tethering or rolling | |
| leukocyte migration | |
| cellular extravasation | |
| cellular response to organic cyclic compound | |
| cellular response to nicotine | |
| cellular response to amino acid stimulus | |
| necrotic cell death | |
| apoptotic process | |
| transformed cell apoptotic process | |
| extracellular matrix organization | |
| immune response | |
| positive regulation of humoral immune response mediated by circulating immunoglobulin | |
| humoral immune response | |
| positive regulation of chronic inflammatory response to antigenic stimulus | |
| chronic inflammatory response to antigenic stimulus | |
| epithelial cell proliferation involved in salivary gland morphogenesis | |
| response to activity | |
| response to drug | |
| response to glucocorticoid stimulus | |
| defense response | |
| response to hypoxia | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| positive regulation of fever generation | |
| response to salt stress | |
| response to mechanical stimulus | |
| negative regulation of lipid storage | |
| negative regulation of branching involved in lung morphogenesis | |
| negative regulation of interleukin-6 production | |
| negative regulation of gene expression | |
| negative regulation of lipid catabolic process | |
| negative regulation of L-glutamate transport | |
| negative regulation of glucose import | |
| positive regulation of protein complex assembly | |
| positive regulation of podosome assembly | |
| positive regulation of protein complex disassembly | |
| positive regulation of cytokine production | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| positive regulation of interferon-gamma production | |
| positive regulation of interleukin-18 production | |
| positive regulation of chemokine (C-X-C motif) ligand 2 production | |
| positive regulation of hair follicle development | |
| regulation of branching involved in salivary gland morphogenesis | |
| positive regulation of protein transport | |
| positive regulation of calcidiol 1-monooxygenase activity | |
| multicellular organismal development | |
| embryonic digestive tract development | |
| organ morphogenesis | |
| skeletal muscle contraction | |
| protein import into nucleus, translocation | |
| glucose metabolic process | |
| sequestering of triglyceride | |
| cytokine activity | |
| tumor necrosis factor receptor binding | |
| protease binding | |
| transcription regulatory region DNA binding | |
| membrane | |
| extracellular region | |
| membrane raft | |
| phagocytic cup | |
| external side of plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| intracellular | |
| recycling endosome | |
| secretory granule | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| MedScan ID | 7124 |
|---|
| Hugo ID | 11892 |
|---|
| Human chromosome position | 6p21.3 |
|---|
| LocusLink ID | 7124 |
|---|---|
| 21926 | |
| 24835 | |
| 257601 | |
| 257551 | |
| 280943 | |
| 405785 |
| Alias | DIF |
|---|---|
| TNFA | |
| TNFSF2 | |
| TNF-alpha | |
| DADB-70P7.1 | |
| tumor necrosis factor | |
| TNF-a | |
| cachectin | |
| APC1 protein | |
| TNF, monocyte-derived | |
| TNF, macrophage-derived | |
| tumor necrosis factor-alpha | |
| tumor necrosis factor ligand superfamily member 2 | |
| Tnfsf1a | |
| TNFalpha | |
| TNF alpha | |
| tumor necrosis factor alpha | |
| RATTNF | |
| tumor necrosis factor (TNF superfamily, member 2) | |
| tumour necrosis factor 2 | |
| TNF precursor | |
| tumor necrosis factor II | |
| tumor necrosis factor superfamily member 2 | |
| tumor necrosis factor, alpha (cachectin) | |
| tumor necrosis factor, alpha (cachetin) | |
| tumor necrotizing factor alpha | |
| tumour necrosis factor | |
| tumour necrosis factor (TNF superfamily, member 2) | |
| tumour necrosis factor alpha | |
| pro-TNF-alpha | |
| tumour necrosis factor II | |
| tumor necrosis factor 2 | |
| tumour necrosis factor superfamily member 2 | |
| tumour necrosis factor, alpha (cachectin) | |
| tumour necrosis factor, alpha (cachetin) | |
| tumour necrotizing factor alpha | |
| cachectin-tumor necrosis factor propeptide | |
| protumor necrosis factor | |
| OTTHUMP00000029281 | |
| pre-tumor necrosis factor | |
| OTTHUMP00000037669 | |
| APC1 gene | |
| LOC257551 | |
| LOC257601 | |
| MGC151434 | |
| TNF | |
| TNFA_HUMAN | |
| MGC124630 | |
| TNF superfamily, member 2 | |
| TNF superfamily, member II | |
| tumor necrosis factor superfamily, member 2 | |
| tumor necrosis factor superfamily, member 2 | |
| tumor necrosis factor superfamily member 2 | |
| TNFSF2s | |
| tumor necrosis factor, alpha | |
| tnf superfamily | |
| DASS-280D8.2 | |
| Tumor necrosis factor alpha (cachetin) | |
| tumor necrosis factor alpha precursor | |
| MGC152825 | |
| TNF1 | |
| alpha | |
| chromosome | |
| scaffold | |
| tumor necrosis factor a (TNF superfamily, member 2) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio | |
| Human |
| OMIM ID | 191160 |
|---|---|
| 600807 | |
| 157300 | |
| 611162 | |
| 248310 | |
| OMIM:191160 |
| Unigene ID | Hs.241570 |
|---|---|
| Mm.1293 | |
| Rn.2275 | |
| Bt.12756 | |
| Dr.89727 |
| KEGG ID | hsa:7124 |
|---|---|
| mmu:21926 | |
| rno:24835 |
| Swiss-Prot Accession | P01375 |
|---|---|
| Q5STB3 | |
| P06804 | |
| Q3U593 | |
| P16599 | |
| O35853 | |
| Q62326 | |
| Q91VF3 | |
| O43647 | |
| Q9P1Q2 | |
| Q9UIV3 | |
| Q6EE11 | |
| Q9JI26 | |
| Q9JI27 | |
| C1K3N5 | |
| Q5RT83 | |
| Q9UBM5 | |
| Q0X0E6 | |
| Q3U4I6 | |
| Q6TDG3 |
| GO ID | 0005125 |
|---|---|
| 0002020 | |
| 0044212 | |
| 0005164 | |
| 0007254 | |
| 0000165 | |
| 0000187 | |
| 0000185 | |
| 0006919 | |
| 0006915 | |
| 0019722 | |
| 0001775 | |
| 0071230 | |
| 0071316 | |
| 0071407 | |
| 0002439 | |
| 0050830 | |
| 0048566 | |
| 0060664 | |
| 0030198 | |
| 0097191 | |
| 0008625 | |
| 0006006 | |
| 0006959 | |
| 0006917 | |
| 0060555 | |
| 0006954 | |
| 0050901 | |
| 0031663 | |
| 0070265 | |
| 0002037 | |
| 0010693 | |
| 0043066 | |
| 0061048 | |
| 0008285 | |
| 0002740 | |
| 0045599 | |
| 0010629 | |
| 0046325 | |
| 0044130 | |
| 0032715 | |
| 0050995 | |
| 0010888 | |
| 0045668 | |
| 0000122 | |
| 0045892 | |
| 0045071 | |
| 0009887 | |
| 0030316 | |
| 0070374 | |
| 0043123 | |
| 0046330 | |
| 0043406 | |
| 0042346 | |
| 0051092 | |
| 0051533 | |
| 0043065 | |
| 0060559 | |
| 2000343 | |
| 0045080 | |
| 0032722 | |
| 0002876 | |
| 0001819 | |
| 0050715 | |
| 0031622 | |
| 0051798 | |
| 0034116 | |
| 0002925 | |
| 0032729 | |
| 0032755 | |
| 0045416 | |
| 0051044 | |
| 0045840 | |
| 0071677 | |
| 0010940 | |
| 0043525 | |
| 0045429 | |
| 0045672 | |
| 0033138 | |
| 0071803 | |
| 0043068 | |
| 0031334 | |
| 0043243 | |
| 0051897 | |
| 2000010 | |
| 0001934 | |
| 0051222 | |
| 0051091 | |
| 0048661 | |
| 0050806 | |
| 0045944 | |
| 0045893 | |
| 0045994 | |
| 0060557 | |
| 0000060 | |
| 0043491 | |
| 0032800 | |
| 0043122 | |
| 0060693 | |
| 0051023 | |
| 0050796 | |
| 0014823 | |
| 0042493 | |
| 0051384 | |
| 0001666 | |
| 0009612 | |
| 0009651 | |
| 0009615 | |
| 0030730 | |
| 0003009 | |
| 0006927 | |
| 0033209 | |
| 0009986 | |
| 0009897 | |
| 0005615 | |
| 0005887 | |
| 0045121 | |
| 0001891 | |
| 0005886 | |
| 0055037 | |
| 0097190 | |
| 0008283 | |
| 0045123 | |
| 0006952 | |
| 0042742 | |
| 0006955 | |
| 0050900 | |
| 0007275 | |
| 0008284 | |
| 0042127 | |
| 0045670 | |
| 0001932 | |
| 0050708 | |
| 0007165 | |
| 0005576 | |
| 0016021 | |
| 0005622 | |
| 0016020 | |
| 0030141 | |
| 0050729 | |
| 0032741 | |
| 0006916 | |
| 0008624 | |
| 0010843 | |
| 0016563 | |
| 0016564 | |
| 0032582 | |
| 0016481 | |
| 0043193 | |
| 0045941 | |
| 0042802 | |
| 0005515 | |
| 0007159 | |
| 0005625 | |
| 0009611 | |
| 0006355 | |
| 0019221 | |
| 0006968 | |
| 0004871 | |
| 0050875 | |
| 0007267 | |
| 0046685 | |
| 0007515 | |
| 0008151 | |
| 0008220 | |
| 0006960 | |
| 0006889 |
| PIR ID | A22908 |
|---|---|
| A93585 | |
| JU0029 |
| Swiss-Prot ID | TNFA_MOUSE |
|---|---|
| TNFA_HUMAN | |
| TNFA_RAT | |
| Q3U593_MOUSE | |
| C1K3N5_HUMAN | |
| Q5STB3_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Membrane | |
| Secreted | |
| Extracellular | |
| Plasma membrane |
| IPI ID | IPI00128861 |
|---|---|
| IPI00001671 | |
| IPI00213948 | |
| IPI00894294 |
| Mouse chromosome position | 17 19.06 cM |
|---|
| Rat chromosome position | 20p12 |
|---|
| Homologene ID | 496 |
|---|
| MGI ID | 104798 |
|---|
| RGD ID | 3876 |
|---|
| Primary Cell Localization | Extracellular |
|---|
| LocatorString | pmquery:egfr+transactivation |
|---|
| Homo sapiens Chromosome position | 6p21.3 |
|---|---|
| 6 |
| Microarray ID | 102629_at |
|---|---|
| 1387691_at | |
| e02468cds_s_at | |
| A_43_P11513 | |
| NM_012675 | |
| 102630_s_at | |
| 1419607_at | |
| TNFa_at | |
| x02611_s_at | |
| Msa.256.0_at | |
| A_65_P16584 | |
| NM_013693.1 | |
| A_51_P385099 | |
| NM_013693 | |
| X01394 | |
| 1852_at | |
| 259_s_at | |
| 207113_s_at | |
| X02910_at | |
| A_23_P376488 | |
| NM_000594.2 | |
| A_32_P458667 | |
| I_3328355 | |
| A_23_P168071 | |
| I_1109711 | |
| A_14_P109737 | |
| A_14_P125975 | |
| A_14_P110091 | |
| A_24_P50759 |
| FunctionalClass | cytokine |
|---|---|
| protein binding | |
| tumor necrosis factor receptor binding | |
| signal transducer |
| Mus musculus Chromosome position | 17 19.06 cM |
|---|
| KEGG pathway | Hematopoietic cell lineage |
|---|---|
| Type II diabetes mellitus | |
| Type I diabetes mellitus | |
| Apoptosis | |
| Cytokine-cytokine receptor interaction | |
| Toll-like receptor signaling pathway | |
| MAPK signaling pathway | |
| TGF-beta signaling pathway | |
| T cell receptor signaling pathway | |
| Adipocytokine signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Natural killer cell mediated cytotoxicity |
| Rattus norvegicus Chromosome position | 20p12 |
|---|
| Bos taurus Chromosome position | 23q22 |
|---|
| Keyword | desmoplakin |
|---|---|
| death receptor | |
| tumor necrosis factor | |
| thrombin | |
| activated blood coagulation factor XIV | |
| LDL | |
| RAS small monomeric GTPase | |
| endotoxin | |
| dechlorinase | |
| receptor | |
| growth factor | |
| desmoplakins | |
| receptor activity | |
| endothelium-derived relaxation factor-forming enzyme | |
| RNA | |
| nuclei | |
| DNA | |
| cytokine activity | |
| nucleus |