| URN | urn:agi-llid:9089 |
|---|---|
| Total Entities | 0 |
| Connectivity | 37 |
| Name | Bag4 |
| Description | BCL2-associated athanogene 4 |
| Notes | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. |
| GO Molecular Function | chaperone binding |
|---|---|
| receptor signaling protein activity |
| GO Cellular Component | nucleolus |
|---|---|
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | positive regulation of protein kinase B signaling cascade |
|---|---|
| positive regulation of peptidyl-serine phosphorylation | |
| negative regulation of mRNA modification | |
| negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | |
| negative regulation of apoptotic process | |
| positive regulation of cell adhesion | |
| positive regulation of fibroblast migration | |
| positive regulation of actin filament polymerization | |
| positive regulation of stress fiber assembly | |
| regulation of apoptotic process | |
| protein folding | |
| protein localization to plasma membrane | |
| cellular response to tumor necrosis factor | |
| cellular response to epidermal growth factor stimulus | |
| apoptotic process | |
| ruffle assembly | |
| protein heterooligomerization |
| Pathway | tumor necrosis factor signaling pathway |
|---|---|
| tumor necrosis factor mediated signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | positive regulation of protein kinase B signaling cascade |
|---|---|
| positive regulation of peptidyl-serine phosphorylation | |
| negative regulation of mRNA modification | |
| negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | |
| negative regulation of apoptotic process | |
| positive regulation of cell adhesion | |
| positive regulation of fibroblast migration | |
| positive regulation of actin filament polymerization | |
| positive regulation of stress fiber assembly | |
| regulation of apoptotic process | |
| protein folding | |
| protein localization to plasma membrane | |
| cellular response to tumor necrosis factor | |
| cellular response to epidermal growth factor stimulus | |
| apoptotic process | |
| ruffle assembly | |
| protein heterooligomerization | |
| chaperone binding | |
| receptor signaling protein activity | |
| nucleolus | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 9089 |
|---|
| Hugo ID | 940 |
|---|
| Human chromosome position | 8p11.23 |
|---|---|
| 8p12 |
| LocusLink ID | 9089 |
|---|---|
| 9530 | |
| 67384 | |
| 361167 | |
| 516353 |
| Alias | SODD |
|---|---|
| BAG-4 | |
| BAG family molecular chaperone regulator 4 | |
| silencer of death domains | |
| bcl-2-associated athanogene 4 | |
| BAG-family molecular chaperone regulator-4 | |
| 2410112I15Rik | |
| BCL2-associated athanogene IV | |
| BAG-family molecular chaperone regulator IV | |
| Silencer of death domain | |
| BAG4 | |
| 2410112I15 | |
| BCL2-associated athanogene 4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus |
| OMIM ID | 603884 |
|---|
| Unigene ID | Hs.194726 |
|---|---|
| Mm.118400 | |
| Rn.163329 | |
| Rn.103897 | |
| Bt.27376 |
| KEGG ID | hsa:9530 |
|---|---|
| mmu:67384 | |
| rno:361167 |
| Swiss-Prot Accession | O95429 |
|---|---|
| A6H6S8 | |
| Q8CI61 | |
| Q5XIR5 | |
| Q3TRL9 | |
| Q91VT5 | |
| Q9CWG2 | |
| B4E217 | |
| O95818 |
| GO ID | 0051087 |
|---|---|
| 0005057 | |
| 0071364 | |
| 0071356 | |
| 0043066 | |
| 2001145 | |
| 0030838 | |
| 0045785 | |
| 0010763 | |
| 0033138 | |
| 0051897 | |
| 0051496 | |
| 0006457 | |
| 0072659 | |
| 0097178 | |
| 0005737 | |
| 0005829 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0006915 | |
| 0090367 | |
| 0051291 | |
| 0042981 | |
| 0006916 | |
| 0016556 | |
| 0005515 | |
| 0005575 | |
| 0051082 | |
| 0008372 |
| Swiss-Prot ID | BAG4_MOUSE |
|---|---|
| BAG4_HUMAN | |
| Q5XIR5_RAT | |
| A6H6S8_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00109089 |
|---|---|
| IPI00030695 | |
| IPI00798092 | |
| IPI00480724 |
| Mouse chromosome position | 8 |
|---|---|
| 8 A3 |
| Rat chromosome position | 16q12.4 |
|---|
| Homologene ID | 31270 |
|---|
| MGI ID | 1914634 |
|---|
| RGD ID | 1560875 |
|---|
| Homo sapiens Chromosome position | 8p12 |
|---|
| Microarray ID | 228189_at |
|---|
| FunctionalClass | protein binding |
|---|---|
| receptor signaling protein | |
| unfolded protein binding |
| Mus musculus Chromosome position | 8 A3 |
|---|
| Rattus norvegicus Chromosome position | 16q12.4 |
|---|
| Bos taurus Chromosome position | 27 |
|---|