| URN | urn:agi-llid:7188 |
|---|---|
| Total Entities | 0 |
| Connectivity | 114 |
| Name | TRAF5 |
| Description | TNF receptor-associated factor 5 |
| Notes | The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | TNFRAP |
|---|
| GO Molecular Function | thioesterase binding |
|---|---|
| ubiquitin protein ligase binding | |
| metal ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity | |
| signal transducer activity |
| GO Cellular Component | centrosome |
|---|---|
| CD40 receptor complex | |
| internal side of plasma membrane | |
| cytoplasm |
| GO Biological Process | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| signal transduction | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of cell proliferation | |
| regulation of apoptotic process | |
| protein ubiquitination | |
| apoptotic process |
| Pathway | TNFRSF5/6 -> RB1/E2F signaling |
|---|---|
| TNFR -> CREB/ELK-SRF signaling | |
| TNFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | TNFRAP |
|---|---|
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| signal transduction | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of cell proliferation | |
| regulation of apoptotic process | |
| protein ubiquitination | |
| apoptotic process | |
| thioesterase binding | |
| ubiquitin protein ligase binding | |
| metal ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity | |
| signal transducer activity | |
| centrosome | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| cytoplasm |
| MedScan ID | 7188 |
|---|
| Hugo ID | 12035 |
|---|
| Human chromosome position | 1q32 |
|---|
| LocusLink ID | 7188 |
|---|---|
| 22033 |
| Alias | RNF84 |
|---|---|
| MGC:39780 | |
| RP11-318L16.2 | |
| TNF receptor-associated factor 5 | |
| RING finger protein 84 | |
| OTTHUMP00000035056 | |
| TRAF5 | |
| TNF receptor-associated factor V | |
| OTTHUMP00000035055 | |
| LOC622602 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 602356 |
|---|
| Unigene ID | Hs.523930 |
|---|---|
| Mm.380491 | |
| Mm.389227 |
| KEGG ID | hsa:7188 |
|---|---|
| mmu:22033 |
| Swiss-Prot Accession | O00463 |
|---|---|
| P70191 | |
| Q61480 | |
| Q6FHY1 |
| GO ID | 0031996 |
|---|---|
| 0031625 | |
| 0004842 | |
| 0008270 | |
| 0006915 | |
| 0043123 | |
| 0051092 | |
| 0051091 | |
| 0042981 | |
| 0007165 | |
| 0035631 | |
| 0005813 | |
| 0009898 | |
| 0046872 | |
| 0004871 | |
| 0008284 | |
| 0016567 | |
| 0005737 |
| PIR ID | JC6539 |
|---|
| Swiss-Prot ID | TRAF5_MOUSE |
|---|---|
| TRAF5_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00323891 |
|---|---|
| IPI00005760 |
| Mouse chromosome position | 1 105.0 cM |
|---|
| Homologene ID | 27079 |
|---|
| MGI ID | 107548 |
|---|
| RGD ID | 1605425 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|