| URN | urn:agi-llid:329 |
|---|---|
| Total Entities | 0 |
| Connectivity | 464 |
| Name | Birc2 |
| Description | baculoviral IAP repeat-containing 2 |
| Notes | The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. |
| Ariadne Ontology | IAP |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | protein N-terminus binding |
|---|---|
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| transcription coactivator activity |
| GO Cellular Component | membrane raft |
|---|---|
| CD40 receptor complex | |
| internal side of plasma membrane | |
| protein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| XY body | |
| nucleus |
| GO Biological Process | regulation of RIG-I signaling pathway |
|---|---|
| regulation of cell cycle | |
| regulation of nucleotide-binding oligomerization domain containing signaling pathway | |
| regulation of toll-like receptor signaling pathway | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| cell surface receptor signaling pathway | |
| NIK-NF-kappaB cascade | |
| regulation of RNA biosynthetic process | |
| regulation of transcription, DNA-dependent | |
| negative regulation of apoptotic process | |
| regulation of apoptotic process | |
| transcription, DNA-dependent | |
| protein polyubiquitination | |
| protein K48-linked ubiquitination | |
| protein K63-linked ubiquitination | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| apoptotic process | |
| necroptosis | |
| cellular component disassembly involved in execution phase of apoptosis | |
| regulation of innate immune response | |
| response to organic nitrogen | |
| response to organic cyclic compound | |
| response to cAMP | |
| response to ethanol | |
| response to hypoxia | |
| regulation of inflammatory response | |
| regulation of cysteine-type endopeptidase activity | |
| placenta development | |
| protein heterooligomerization |
| Pathway | Apoptosis |
|---|---|
| ripk2-Xiap | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | IAP |
|---|---|
| regulation of RIG-I signaling pathway | |
| regulation of cell cycle | |
| regulation of nucleotide-binding oligomerization domain containing signaling pathway | |
| regulation of toll-like receptor signaling pathway | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| cell surface receptor signaling pathway | |
| NIK-NF-kappaB cascade | |
| regulation of RNA biosynthetic process | |
| regulation of transcription, DNA-dependent | |
| negative regulation of apoptotic process | |
| regulation of apoptotic process | |
| transcription, DNA-dependent | |
| protein polyubiquitination | |
| protein K48-linked ubiquitination | |
| protein K63-linked ubiquitination | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| apoptotic process | |
| necroptosis | |
| cellular component disassembly involved in execution phase of apoptosis | |
| regulation of innate immune response | |
| response to organic nitrogen | |
| response to organic cyclic compound | |
| response to cAMP | |
| response to ethanol | |
| response to hypoxia | |
| regulation of inflammatory response | |
| regulation of cysteine-type endopeptidase activity | |
| placenta development | |
| protein heterooligomerization | |
| protein N-terminus binding | |
| metal ion binding | |
| zinc ion binding | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| transcription coactivator activity | |
| membrane raft | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| protein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| XY body | |
| nucleus | |
| Biofluids assayable substances |
| MedScan ID | 329 |
|---|
| Hugo ID | 590 |
|---|
| Human chromosome position | 11q22 |
|---|
| LocusLink ID | 329 |
|---|---|
| 11797 | |
| 60371 |
| Alias | API1 |
|---|---|
| MIHB | |
| HIAP2 | |
| RNF48 | |
| cIAP1 | |
| Hiap-2 | |
| c-IAP1 | |
| baculoviral IAP repeat-containing protein 2 | |
| IAP-2 | |
| IAP homolog B | |
| apoptosis inhibitor 1 | |
| RING finger protein 48 | |
| inhibitor of apoptosis protein 2 | |
| baculoviral IAP repeat-containing 2 | |
| NFR2-TRAF signalling complex protein | |
| TNFR2-TRAF-signaling complex protein 2 | |
| Api2 | |
| IAP1 | |
| IAP2 | |
| MIHC | |
| Birc3 | |
| HIAP1 | |
| MIAP1 | |
| MIAP2 | |
| cIAP2 | |
| mcIAP1 | |
| AW146227 | |
| mIAP-2 | |
| apoptosis inhibitor 2 | |
| baculoviral IAP repeat-containing 3 | |
| rIAP1 | |
| inhibitor of apoptosis protein | |
| TNFR2-TRAF signaling complex protein II | |
| inhibitor of apoptosis I | |
| inhibitor of apoptosis protein (IAP)1 | |
| MIAP I | |
| inhibitor of apoptosis 1 | |
| TNFR2-TRAF signaling complex protein 2 | |
| API I | |
| apoptosis inhibitor I | |
| baculoviral IAP repeat-containing II | |
| BIRC2 | |
| cIAP I | |
| C-IAP I | |
| inhibitor of apoptosis (cIAP)-1 | |
| inhibitor of apoptosis protein 1 | |
| Inhibitor of apoptosis protein II | |
| inhibitor of apoptosis protein I | |
| Inhibitor of apoptosis protein 2 | |
| TNFR2-TRAF signaling complex protein 2 | |
| apoptosis inhibitor II | |
| TNFR2-TRAF signaling complex protein II | |
| C-IAP1s | |
| C-IAP Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601712 |
|---|
| Unigene ID | Hs.696238 |
|---|---|
| Hs.731943 | |
| Mm.335659 | |
| Rn.205955 | |
| Rn.216766 |
| KEGG ID | hsa:329 |
|---|---|
| mmu:11797 | |
| rno:60371 |
| Swiss-Prot Accession | Q13490 |
|---|---|
| B4E026 | |
| Q62210 | |
| Q6P6S1 | |
| A6H6S7 | |
| O08864 | |
| Q16516 | |
| Q4TTG0 | |
| Q8IZZ0 | |
| O88642 | |
| Q9ESE8 | |
| Q9QZC6 |
| EC Number | 6.3.2.- |
|---|
| GO ID | 0047485 |
|---|---|
| 0003713 | |
| 0004842 | |
| 0008270 | |
| 0038061 | |
| 0006915 | |
| 0007166 | |
| 0006921 | |
| 0070266 | |
| 0043066 | |
| 0001890 | |
| 0043123 | |
| 0043161 | |
| 0000209 | |
| 0039535 | |
| 0051726 | |
| 0045595 | |
| 0042127 | |
| 2000116 | |
| 0050727 | |
| 0045088 | |
| 0070424 | |
| 0034121 | |
| 0006355 | |
| 0006351 | |
| 0035631 | |
| 0005829 | |
| 0009898 | |
| 0005634 | |
| 0016874 | |
| 0046872 | |
| 0051291 | |
| 2001141 | |
| 0042981 | |
| 0001666 | |
| 0001741 | |
| 0005737 | |
| 0005622 | |
| 0045121 | |
| 0043234 | |
| 0051591 | |
| 0045471 | |
| 0014070 | |
| 0010243 | |
| 0070936 | |
| 0070534 | |
| 0006916 | |
| 0005515 | |
| 0003674 | |
| 0004871 |
| PIR ID | S68450 |
|---|
| Swiss-Prot ID | BIRC2_MOUSE |
|---|---|
| BIRC2_HUMAN | |
| Q6P6S1_RAT | |
| A6H6S7_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00311533 |
|---|---|
| IPI00013418 | |
| IPI00421512 | |
| IPI00559012 |
| Mouse chromosome position | 9 |
|---|---|
| 9 A1 |
| Rat chromosome position | 8q11 |
|---|
| Homologene ID | 900 |
|---|
| MGI ID | 1197009 |
|---|
| RGD ID | 620690 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|