Protein Inppl1

URN	urn:agi-llid:3636
Total Entities	0
Connectivity	334
Name	Inppl1
Description	inositol polyphosphate phosphatase-like 1
Notes	The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

GO Molecular Function	hydrolase activity
	inositol-polyphosphate 5-phosphatase activity
	actin binding
	SH3 domain binding
	SH2 domain binding
	phosphatidylinositol-3,4,5-trisphosphate binding

GO Biological Process	immune system process
	small molecule metabolic process
	phosphatidylinositol biosynthetic process
	negative regulation of MAP kinase activity
	glucose metabolic process
	cellular lipid metabolic process
	phospholipid metabolic process
	phosphatidylinositol dephosphorylation
	inositol phosphate metabolic process
	inositol trisphosphate metabolic process
	post-embryonic development
	endochondral ossification
	brain development
	negative regulation of neuron projection development
	cell adhesion
	actin filament organization
	negative regulation of insulin-like growth factor receptor signaling pathway
	negative regulation of insulin receptor signaling pathway
	negative regulation of platelet-derived growth factor receptor signaling pathway
	ruffle assembly
	negative regulation of cell proliferation
	response to drug
	response to insulin
	negative regulation of DNA replication
	negative regulation of gene expression
	dephosphorylation
	endocytosis

Pathway	IGF1 in Muscle Hypertrophy
	Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2
	phosphatidylinositol 3-kinase-Akt signaling pathway
	phosphatidylinositol 3-kinase-Akt signaling pathway
	phosphatidylinositol 3-kinase-Akt signaling pathway

Group	immune system process
	small molecule metabolic process
	phosphatidylinositol biosynthetic process
	negative regulation of MAP kinase activity
	glucose metabolic process
	cellular lipid metabolic process
	phospholipid metabolic process
	phosphatidylinositol dephosphorylation
	inositol phosphate metabolic process
	inositol trisphosphate metabolic process
	post-embryonic development
	endochondral ossification
	brain development
	negative regulation of neuron projection development
	cell adhesion
	actin filament organization
	negative regulation of insulin-like growth factor receptor signaling pathway
	negative regulation of insulin receptor signaling pathway
	negative regulation of platelet-derived growth factor receptor signaling pathway
	ruffle assembly
	negative regulation of cell proliferation
	response to drug
	response to insulin
	negative regulation of DNA replication
	negative regulation of gene expression
	hydrolase activity
	inositol-polyphosphate 5-phosphatase activity
	dephosphorylation
	endocytosis
	actin binding
	SH3 domain binding
	SH2 domain binding
	phosphatidylinositol-3,4,5-trisphosphate binding
	membrane
	plasma membrane
	cell projection
	cytoplasm
	Golgi apparatus
	cytosol
	cytoskeleton
	filopodium
	lamellipodium

Alias	OPSMD
	SHIP2
	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
	SHIP-2
	INPPL-1
	51C protein
	protein 51C
	SH2 domain-containing inositol 5'-phosphatase 2
	SH2 domain-containing inositol-5'-phosphatase 2
	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
	51C
	ablSH3-binding protein
	SH2 domain-containing inositol phosphatase 2
	inositol polyphosphate phosphatase-like protein 1
	SH2-containing inositol phosphatase 2
	inositol polyphosphate phosphatase-like 1
	SH2-containing inositol phosphatase II
	INPPL1
	inositol polyphosphate phosphatase-like I
	INPPL I
	INPPL Is
	INPPL1s
	51(C)
	51-C

Mouse chromosome position	7

OMIM ID	600829
	258480

Rat chromosome position	1q32

Hugo ID	6080
	HGNC:6080

Human chromosome position	11q13
	11q23

PIR ID	JC5765

EC Number	3.1.3.86

Homologene ID	1204

MGI ID	1333787
	MGI:1333787

RGD ID	68396

MedScan ID	3636