| URN | urn:agi-llid:3635 |
|---|---|
| Total Entities | 0 |
| Connectivity | 625 |
| Name | Inpp5d |
| Description | inositol polyphosphate-5-phosphatase D |
| Notes | phosphatase involved in the inhibitory action of the mast cell function-associated antigen [RGD] |
| GO Molecular Function | hydrolase activity |
|---|---|
| inositol-4,5-bisphosphate 5-phosphatase activity | |
| inositol-polyphosphate 5-phosphatase activity | |
| phosphatidylinositol trisphosphate phosphatase activity | |
| SH3 domain binding | |
| PTB domain binding |
| GO Cellular Component | membrane |
|---|---|
| actin filament | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| cortical cytoskeleton |
| GO Biological Process | immune system process |
|---|---|
| leukocyte migration | |
| positive regulation of erythrocyte differentiation | |
| positive regulation of lymphocyte differentiation | |
| positive regulation of B cell differentiation | |
| negative regulation of monocyte differentiation | |
| negative regulation of granulocyte differentiation | |
| negative regulation of osteoclast differentiation | |
| negative regulation of neutrophil differentiation | |
| T cell receptor signaling pathway | |
| immunoglobulin mediated immune response | |
| negative regulation of immune response | |
| negative regulation of B cell activation | |
| negative regulation of B cell proliferation | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phospholipid metabolic process | |
| phosphatidylinositol dephosphorylation | |
| inositol phosphate metabolic process | |
| determination of adult lifespan | |
| negative regulation of bone resorption | |
| negative regulation of interleukin-6 biosynthetic process | |
| blood coagulation | |
| signal transduction | |
| negative regulation of signal transduction | |
| intracellular signal transduction | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| negative regulation of cell proliferation | |
| phosphate-containing compound metabolic process | |
| dephosphorylation |
| Pathway | Androgen Receptor to Akt Signaling in Prostate Cancer |
|---|---|
| Osteoclast Activation in Multiple Myeloma | |
| B-cell Activation in Systemic Lupus Erythematosus | |
| T-cell-Independent B-cell Activation | |
| Natural Killer Cell Inhibitory Receptor Signaling | |
| Natural Killer Cell Activation | |
| Impairment of Microglia Inhibition by Motor Neuron in Amyotrophic Lateral Sclerosis | |
| Preconditioning Ischemia | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| Erythropoietin/ELK-SRF Expression Targets | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | immune system process |
|---|---|
| leukocyte migration | |
| positive regulation of erythrocyte differentiation | |
| positive regulation of lymphocyte differentiation | |
| positive regulation of B cell differentiation | |
| negative regulation of monocyte differentiation | |
| negative regulation of granulocyte differentiation | |
| negative regulation of osteoclast differentiation | |
| negative regulation of neutrophil differentiation | |
| T cell receptor signaling pathway | |
| immunoglobulin mediated immune response | |
| negative regulation of immune response | |
| negative regulation of B cell activation | |
| negative regulation of B cell proliferation | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phospholipid metabolic process | |
| phosphatidylinositol dephosphorylation | |
| inositol phosphate metabolic process | |
| determination of adult lifespan | |
| negative regulation of bone resorption | |
| negative regulation of interleukin-6 biosynthetic process | |
| blood coagulation | |
| signal transduction | |
| negative regulation of signal transduction | |
| intracellular signal transduction | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| negative regulation of cell proliferation | |
| hydrolase activity | |
| inositol-4,5-bisphosphate 5-phosphatase activity | |
| inositol-polyphosphate 5-phosphatase activity | |
| phosphatidylinositol trisphosphate phosphatase activity | |
| phosphate-containing compound metabolic process | |
| dephosphorylation | |
| SH3 domain binding | |
| PTB domain binding | |
| membrane | |
| actin filament | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| cortical cytoskeleton | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 3635 |
|---|---|
| 16331 | |
| 54259 |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane | |
| Cell membrane |
| GO ID | 0051425 |
|---|---|
| 0017124 | |
| 0004445 | |
| 0034594 | |
| 0050852 | |
| 0006915 | |
| 0007596 | |
| 0008340 | |
| 0016064 | |
| 0043647 | |
| 0035556 | |
| 0050900 | |
| 0030889 | |
| 0045779 | |
| 0050777 | |
| 0045409 | |
| 0045656 | |
| 0045659 | |
| 0045671 | |
| 0009968 | |
| 0006796 | |
| 0006661 | |
| 0046856 | |
| 0006644 | |
| 0045579 | |
| 0043065 | |
| 0045648 | |
| 0007165 | |
| 0044281 | |
| 0005829 | |
| 0016020 | |
| 0016787 | |
| 0030487 | |
| 0016311 | |
| 0002376 | |
| 0050869 | |
| 0008285 | |
| 0030853 | |
| 0045621 | |
| 0005884 | |
| 0030863 | |
| 0005737 | |
| 0005622 | |
| 0005886 | |
| 0004437 | |
| 0005515 | |
| 0006955 | |
| 0007242 |
| Alias | SHIP |
|---|---|
| SHIP1 | |
| SHIP-1 | |
| hp51CN | |
| SIP-145 | |
| phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | |
| p150Ship | |
| SH2 domain-containing inositol phosphatase 1 | |
| SH2 containing inositol phosphatase, isoform b | |
| SH2 domain-containing inositol 5'-phosphatase 1 | |
| SH2 domain-containing inositol-5'-phosphatase 1 | |
| inositol polyphosphate-5-phosphatase of 145 kDa | |
| signaling inositol polyphosphate 5 phosphatase SIP-145 | |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 | |
| s-SHIP | |
| AI323613 | |
| SH2 containing inositol phosphotase | |
| SH2-containing inositol phosphatase SHIP | |
| inositol polyphosphate-5-phosphatase, 145 kDa | |
| Src homology 2 domain-containing inositol-5-phosphatase | |
| Inositol polyphosphate-5-phosphatase 145 kDa | |
| SH2 containing inositol phosphatase | |
| SH2 containing inositol-5-phosphatase | |
| SH2-containing Inositide phosphatase | |
| LOC653796 | |
| INPP5D | |
| MGC117680 | |
| OTTHUMP00000203442 | |
| inositol polyphosphate-5-phosphatase, 145kD | |
| MGC104855 | |
| 145kDa inositol polyphosphate-5-phosphatase | |
| MGC142140 | |
| MGC142142 | |
| OTTHUMP00000165069 | |
| OTTHUMP00000165070 | |
| OTTHUMP00000165071 | |
| OTTHUMP00000165072 | |
| inositol polyphosphate-5-phosphatase D | |
| 145kDa |
| Mouse chromosome position | 1 44.44 cM |
|---|---|
| 1 57.0 cM |
| OMIM ID | 601582 |
|---|
| Rat chromosome position | 9q35 |
|---|
| Hugo ID | 6079 |
|---|
| Human chromosome position | 2q37.1 |
|---|
| Swiss-Prot Accession | Q92835 |
|---|---|
| Q9ES52 | |
| Q3UEU0 | |
| P97573 | |
| O00145 | |
| Q13544 | |
| Q13545 | |
| Q6P5A4 | |
| Q92656 | |
| Q9UE80 | |
| Q3UPF9 | |
| Q4U212 | |
| Q61034 | |
| Q61173 | |
| Q61181 | |
| Q9JKR7 | |
| Q9JLF9 | |
| Q9JLG0 | |
| Q9QVN8 | |
| Q9WUC2 |
| PIR ID | JC4889 |
|---|---|
| JC6118 |
| Unigene ID | Hs.262886 |
|---|---|
| Hs.601911 | |
| Mm.15105 | |
| Rn.10659 |
| KEGG ID | hsa:3635 |
|---|---|
| mmu:16331 | |
| rno:54259 |
| Swiss-Prot ID | SHIP1_RAT |
|---|---|
| SHIP1_HUMAN | |
| SHIP1_MOUSE |
| EC Number | 3.1.3.86 |
|---|
| Ensembl ID | ENSG00000168918 |
|---|---|
| ENSP00000352575 | |
| ENST00000359570 | |
| ENSP00000404610 | |
| ENST00000455936 | |
| ENSMUSG00000026288 | |
| ENSMUSP00000044647 | |
| ENSMUST00000042275 | |
| ENSMUSP00000131244 | |
| ENSMUST00000168783 | |
| ENSMUSP00000127941 | |
| ENSMUST00000169754 | |
| ENSRNOG00000017020 | |
| ENSRNOP00000040111 | |
| ENSRNOT00000051338 |
| Homologene ID | 4046 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 107357 |
|---|
| RGD ID | 2914 |
|---|
| MedScan ID | 3635 |
|---|