| URN | urn:agi-llid:23239 |
|---|---|
| Total Entities | 0 |
| Connectivity | 240 |
| Name | Phlpp1 |
| Description | PH domain and leucine rich repeat protein phosphatase 1 |
| Notes | a circadian rhythm protein; may have a role in the intracellular signaling in the suprachiasmatic nucleus [RGD] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| metal ion binding |
| GO Cellular Component | membrane |
|---|---|
| nuclear membrane | |
| nucleoplasm | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | innate immune response |
|---|---|
| Fc-epsilon receptor signaling pathway | |
| negative regulation of protein kinase C signaling | |
| negative regulation of protein kinase B signaling | |
| phosphatidylinositol-mediated signaling | |
| neurotrophin TRK receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| apoptotic process | |
| entrainment of circadian clock | |
| protein dephosphorylation | |
| circadian rhythm |
| Pathway | protein kinase C (PKC) signaling pathway |
|---|---|
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | Phosphatases |
|---|---|
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| negative regulation of protein kinase C signaling | |
| negative regulation of protein kinase B signaling | |
| phosphatidylinositol-mediated signaling | |
| neurotrophin TRK receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| apoptotic process | |
| entrainment of circadian clock | |
| catalytic activity | |
| hydrolase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein dephosphorylation | |
| circadian rhythm | |
| metal ion binding | |
| membrane | |
| nuclear membrane | |
| nucleoplasm | |
| cytoplasm | |
| cytosol | |
| nucleus |
| LocusLink ID | 23239 |
|---|---|
| 98432 | |
| 59265 |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane | |
| Nucleus |
| GO ID | 0046872 |
|---|---|
| 0004721 | |
| 0038095 | |
| 0006915 | |
| 0009649 | |
| 0007173 | |
| 0008543 | |
| 0045087 | |
| 0048011 | |
| 0048015 | |
| 0005829 | |
| 0016020 | |
| 0005634 | |
| 0003824 | |
| 0016787 | |
| 0004722 | |
| 0051898 | |
| 0090038 | |
| 0006470 | |
| 0005737 | |
| 0031965 | |
| 0005654 | |
| 0007623 | |
| 0005543 | |
| 0008152 | |
| 0030145 |
| Alias | SCOP |
|---|---|
| PHLPP | |
| PLEKHE1 | |
| PH domain leucine-rich repeat-containing protein phosphatase 1 | |
| SCN circadian oscillatory protein | |
| PH domain-containing family E member 1 | |
| suprachiasmatic nucleus circadian oscillatory protein | |
| pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 | |
| AI836256 | |
| mKIAA0606 | |
| pleckstrin homology domain-containing family E member 1 | |
| PH domain leucine-rich repeat protein phosphatase 1 | |
| Circadian Oscillatory Protein (SCOP) | |
| pleckstrin homology domain-containing family E protein 1 | |
| PHLPP1 | |
| PLEKHE I | |
| hSCOP | |
| circadian oscillatory protein | |
| KIAA0606 | |
| MGC161555 | |
| OTTMUSP00000024002 | |
| PH domain and leucine rich repeat protein phosphatase | |
| PH domain and leucine rich repeat protein phosphatase 1 |
| Mouse chromosome position | 1 |
|---|
| OMIM ID | 609396 |
|---|
| Rat chromosome position | 13p13 |
|---|
| Hugo ID | 20610 |
|---|
| Human chromosome position | 18q21.33 |
|---|
| Swiss-Prot Accession | O60346 |
|---|---|
| Q8CHE4 | |
| Q9WTR8 | |
| Q6PCN0 | |
| Q8QZU8 | |
| Q8R5E5 | |
| Q99KL6 | |
| A1A4F5 | |
| Q641Q7 | |
| Q6P4C4 | |
| Q6PJI6 | |
| Q86TN6 | |
| Q96FK2 | |
| Q9NUY1 | |
| Q9H380 |
| PIR ID | T00258 |
|---|
| Unigene ID | Hs.465337 |
|---|---|
| Mm.24115 | |
| Rn.163214 |
| KEGG ID | hsa:23239 |
|---|---|
| mmu:98432 | |
| rno:59265 |
| Swiss-Prot ID | PHLP1_RAT |
|---|---|
| PHLP1_MOUSE | |
| PHLP1_HUMAN | |
| PHLPP_HUMAN | |
| PHLPP_MOUSE | |
| PHLPP_RAT |
| EC Number | 3.1.3.16 |
|---|
| Ensembl ID | ENSG00000081913 |
|---|---|
| ENSP00000262719 | |
| ENST00000262719 | |
| ENSMUSG00000044340 | |
| ENSMUSP00000056530 | |
| ENSMUST00000061047 | |
| ENSRNOG00000002821 | |
| ENSRNOP00000003840 | |
| ENSRNOT00000003840 |
| Homologene ID | 11015 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2138327 |
|---|
| RGD ID | 621308 |
|---|
| MedScan ID | 23239 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00201074 |
|---|---|
| IPI00297617 | |
| IPI00172310 | |
| IPI00874166 | |
| IPI00017920 | |
| IPI00850749 |