| URN | urn:agi-llid:3635 |
|---|---|
| Connectivity | 303 |
| Name | Inpp5d |
| Description | inositol polyphosphate-5-phosphatase D |
| Notes | phosphatase involved in the inhibitory action of the mast cell function-associated antigen [RGD] |
| Pathway | ErythropoietinR -> ELK-SRF/FOS signaling |
|---|---|
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| SH3 domain binding | |
| PTB domain binding | |
| inositol or phosphatidylinositol phosphatase activity | |
| phosphatidylinositol trisphosphate phosphatase activity | |
| inositol-polyphosphate 5-phosphatase activity | |
| inositol-4,5-bisphosphate 5-phosphatase activity |
| GO Cellular Component | membrane |
|---|---|
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| determination of adult lifespan | |
| positive regulation of lymphocyte differentiation | |
| negative regulation of granulocyte differentiation | |
| negative regulation of monocyte differentiation | |
| negative regulation of osteoclast differentiation | |
| negative regulation of neutrophil differentiation | |
| positive regulation of B cell differentiation | |
| positive regulation of erythrocyte differentiation | |
| negative regulation of interleukin-6 biosynthetic process | |
| negative regulation of bone resorption | |
| signal transduction | |
| negative regulation of signal transduction | |
| negative regulation of B cell proliferation | |
| positive regulation of apoptosis | |
| negative regulation of B cell activation | |
| phosphate metabolic process | |
| dephosphorylation | |
| apoptosis | |
| negative regulation of immune response | |
| immunoglobulin mediated immune response | |
| intracellular signaling pathway |
| Group | negative regulation of cell proliferation |
|---|---|
| determination of adult lifespan | |
| positive regulation of lymphocyte differentiation | |
| negative regulation of granulocyte differentiation | |
| negative regulation of monocyte differentiation | |
| negative regulation of osteoclast differentiation | |
| negative regulation of neutrophil differentiation | |
| positive regulation of B cell differentiation | |
| positive regulation of erythrocyte differentiation | |
| negative regulation of interleukin-6 biosynthetic process | |
| negative regulation of bone resorption | |
| signal transduction | |
| negative regulation of signal transduction | |
| negative regulation of B cell proliferation | |
| positive regulation of apoptosis | |
| negative regulation of B cell activation | |
| phosphate metabolic process | |
| dephosphorylation | |
| apoptosis | |
| negative regulation of immune response | |
| immunoglobulin mediated immune response | |
| intracellular signaling pathway | |
| hydrolase activity | |
| SH3 domain binding | |
| PTB domain binding | |
| inositol or phosphatidylinositol phosphatase activity | |
| phosphatidylinositol trisphosphate phosphatase activity | |
| inositol-polyphosphate 5-phosphatase activity | |
| inositol-4,5-bisphosphate 5-phosphatase activity | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol |
| MedScan ID | 3635 |
|---|
| Hugo ID | 6079 |
|---|
| Human chromosome position | 2q37.1 |
|---|
| LocusLink ID | 3635 |
|---|---|
| 16331 | |
| 54259 |
| Alias | SHIP |
|---|---|
| SHIP1 | |
| hp51CN | |
| SIP-145 | |
| MGC104855 | |
| MGC142140 | |
| MGC142142 | |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 | |
| SHIP-1 | |
| p150Ship | |
| OTTHUMP00000165069 | |
| OTTHUMP00000165070 | |
| OTTHUMP00000165071 | |
| OTTHUMP00000165072 | |
| OTTHUMP00000203442 | |
| SH2 domain-containing inositol phosphatase 1 | |
| SH2 containing inositol phosphatase, isoform b | |
| SH2 domain-containing inositol-5'-phosphatase 1 | |
| inositol polyphosphate-5-phosphatase of 145 kDa | |
| signaling inositol polyphosphate 5 phosphatase SIP-145 | |
| s-SHIP | |
| AI323613 | |
| MGC117680 | |
| SH2 containing inositol phosphotase | |
| SH2-containing inositol phosphatase SHIP | |
| inositol polyphosphate-5-phosphatase, 145 kDa | |
| Src homology 2 domain-containing inositol-5-phosphatase | |
| Inositol polyphosphate-5-phosphatase 145 kDa | |
| 145kDa inositol polyphosphate-5-phosphatase | |
| inositol polyphosphate-5-phosphatase D | |
| inositol polyphosphate-5-phosphatase, 145kD | |
| INPP5D | |
| LOC653796 | |
| SH2 containing inositol phosphatase | |
| SH2 containing inositol-5-phosphatase | |
| SH2-containing Inositide phosphatase | |
| inositol polyphosphate-5-phosphatase, 145kDa | |
| 145kDa |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601582 |
|---|
| Mouse chromosome position | 1 57.0 cM |
|---|
| GO ID | 0051425 |
|---|---|
| 0017124 | |
| 0016787 | |
| 0030487 | |
| 0004445 | |
| 0034594 | |
| 0008340 | |
| 0016064 | |
| 0030889 | |
| 0045779 | |
| 0008285 | |
| 0050777 | |
| 0045409 | |
| 0045656 | |
| 0045659 | |
| 0045671 | |
| 0009968 | |
| 0006796 | |
| 0045579 | |
| 0043065 | |
| 0045648 | |
| 0007165 | |
| 0005737 | |
| 0005829 | |
| 0005886 | |
| 0005625 | |
| 0004437 | |
| 0006915 | |
| 0023034 | |
| 0050869 | |
| 0030853 | |
| 0045621 | |
| 0016020 | |
| 0016311 | |
| 0007242 | |
| 0005515 | |
| 0006955 |
| Rat chromosome position | 9q35 |
|---|
| Swiss-Prot Accession | Q92835 |
|---|---|
| Q9ES52 | |
| Q3UEU0 | |
| Q9ESD5 | |
| Q9QZC9 | |
| Q9QZD0 | |
| P97573 | |
| O00145 | |
| Q13544 | |
| Q13545 | |
| Q6P5A4 | |
| Q92656 | |
| Q9UE80 | |
| Q3UPF9 | |
| Q4U212 | |
| Q61034 | |
| Q61173 | |
| Q61181 | |
| Q9JKR7 | |
| Q9JLF9 | |
| Q9JLG0 | |
| Q9QVN8 | |
| Q9WUC2 |
| PIR ID | JC4889 |
|---|---|
| JC6118 |
| Unigene ID | Hs.262886 |
|---|---|
| Hs.601911 | |
| Mm.15105 | |
| Rn.10659 |
| KEGG ID | hsa:3635 |
|---|---|
| mmu:16331 | |
| rno:54259 |
| EC Number | 3.1.3.n1 |
|---|
| Swiss-Prot ID | SHIP1_RAT |
|---|---|
| SHIP1_HUMAN | |
| SHIP1_MOUSE | |
| Q3UEU0_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane | |
| Cell membrane |
| IPI ID | IPI00187836 |
|---|---|
| IPI00329213 | |
| IPI00604549 | |
| IPI00847557 | |
| IPI00120516 | |
| IPI00124504 | |
| IPI00856529 | |
| IPI00857008 | |
| IPI00857200 | |
| IPI00857938 | |
| IPI00339051 |
| Homologene ID | 4046 |
|---|
| RGD ID | 2914 |
|---|
| MGI ID | 107357 |
|---|
| Source | Curated |
|---|