| URN | urn:agi-llid:5293 |
|---|---|
| Total Entities | 0 |
| Connectivity | 417 |
| Name | Pik3cd |
| Description | phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) |
| Notes | Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM] |
| GO Molecular Function | 1-phosphatidylinositol-3-kinase activity |
|---|---|
| phosphatidylinositol 3-kinase activity | |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | phosphatidylinositol 3-kinase complex |
|---|---|
| plasma membrane | |
| cytoplasm | |
| cytosol |
| GO Biological Process | immune system process |
|---|---|
| B cell homeostasis | |
| T cell differentiation | |
| natural killer cell differentiation | |
| mast cell differentiation | |
| T cell receptor signaling pathway | |
| B cell receptor signaling pathway | |
| respiratory burst involved in defense response | |
| mast cell degranulation | |
| adaptive immune response | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| natural killer cell activation | |
| T cell activation | |
| B cell activation | |
| mast cell chemotaxis | |
| B cell chemotaxis | |
| T cell chemotaxis | |
| natural killer cell chemotaxis | |
| neutrophil chemotaxis | |
| neutrophil extravasation | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phosphatidylinositol-3-phosphate biosynthetic process | |
| phospholipid metabolic process | |
| phosphatidylinositol phosphorylation | |
| cytokine production | |
| cell differentiation | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| neurotrophin TRK receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| chemotaxis | |
| inflammatory response | |
| protein phosphorylation | |
| phosphorylation |
| Pathway | phosphatidylinositol 3-kinase-Akt signaling pathway |
|---|---|
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | PI3K |
|---|---|
| immune system process | |
| B cell homeostasis | |
| T cell differentiation | |
| natural killer cell differentiation | |
| mast cell differentiation | |
| T cell receptor signaling pathway | |
| B cell receptor signaling pathway | |
| respiratory burst involved in defense response | |
| mast cell degranulation | |
| adaptive immune response | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| natural killer cell activation | |
| T cell activation | |
| B cell activation | |
| mast cell chemotaxis | |
| B cell chemotaxis | |
| T cell chemotaxis | |
| natural killer cell chemotaxis | |
| neutrophil chemotaxis | |
| neutrophil extravasation | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phosphatidylinositol-3-phosphate biosynthetic process | |
| 1-phosphatidylinositol-3-kinase activity | |
| phospholipid metabolic process | |
| phosphatidylinositol phosphorylation | |
| phosphatidylinositol 3-kinase activity | |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| cytokine production | |
| cell differentiation | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| neurotrophin TRK receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| chemotaxis | |
| inflammatory response | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| protein phosphorylation | |
| phosphorylation | |
| nucleotide binding | |
| ATP binding | |
| phosphatidylinositol 3-kinase complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| Secreted proteins |
| LocusLink ID | 5293 |
|---|---|
| 18707 | |
| 366508 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016303 |
|---|---|
| 0035005 | |
| 0005524 | |
| 0035004 | |
| 0046934 | |
| 0042113 | |
| 0035754 | |
| 0001782 | |
| 0050853 | |
| 0038095 | |
| 0042110 | |
| 0010818 | |
| 0030217 | |
| 0050852 | |
| 0002250 | |
| 0001816 | |
| 0007173 | |
| 0008543 | |
| 0006954 | |
| 0045087 | |
| 0002551 | |
| 0043303 | |
| 0060374 | |
| 0030101 | |
| 0035747 | |
| 0001779 | |
| 0048011 | |
| 0030593 | |
| 0072672 | |
| 0014065 | |
| 0006661 | |
| 0036092 | |
| 0048015 | |
| 0006644 | |
| 0006468 | |
| 0002679 | |
| 0007165 | |
| 0044281 | |
| 0005829 | |
| 0005942 | |
| 0005886 | |
| 0016301 | |
| 0000166 | |
| 0016773 | |
| 0016740 | |
| 0016772 | |
| 0030154 | |
| 0007166 | |
| 0006935 | |
| 0002376 | |
| 0046854 | |
| 0016310 | |
| 0005737 | |
| 0005488 | |
| 0004428 |
| Alias | APDS |
|---|---|
| PI3K | |
| IMD14 | |
| p110D | |
| P110DELTA | |
| RP11-558F24.3 | |
| phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | |
| PI3Kdelta | |
| phosphoinositide-3-kinase C | |
| PI3-kinase p110 subunit delta | |
| ptdIns-3-kinase subunit p110-delta | |
| phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform | |
| AW545373 | |
| 2410099E07Rik | |
| 2610208K16Rik | |
| RP23-422H14.3 | |
| PI3K-delta | |
| p100 delta | |
| PI3-kinase subunit delta | |
| ptdIns-3-kinase subunit delta | |
| phosphoinositide 3 kinase P110delta | |
| phosphatidylinositol 3-kinase p110 delta | |
| catalytic phosphatidylinositol 3-kinase delta | |
| phosphatidylinositol 3-kinase catalytic subunit delta | |
| phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta | |
| phosphoinositide-3-kinase, catalytic, delta polypeptide | |
| phosphatidylinositol 3-kinase catalytic delta polypeptide | |
| RIKEN cDNA 2610208K16 gene | |
| PIK3CD | |
| RIKEN cDNA 2410099E07 gene | |
| OTTMUSP00000010953 | |
| 2610208K16 | |
| OTTHUMP00000001595 | |
| OTTHUMP00000001596 | |
| OTTMUSP00000010950 | |
| OTTMUSP00000038630 | |
| OTTMUSP00000010949 | |
| phosphatidylinositol 3-kinase catalytic subunit | |
| 2410099E07 | |
| phosphatidylinositol 3-kinase, catalytic, delta polypeptide | |
| Phosphatidylinositol 3-kinase catalytic subunit, delta isoform | |
| phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) |
| Mouse chromosome position | 4 |
|---|---|
| 4 E2 |
| OMIM ID | 602839 |
|---|
| Rat chromosome position | 5q36 |
|---|
| Hugo ID | 8977 |
|---|
| Human chromosome position | 1p36.2 |
|---|
| Swiss-Prot Accession | A7E2E0 |
|---|---|
| O00329 | |
| B7ZM44 | |
| Q5SR50 | |
| Q3T9Y0 | |
| Q3UDT3 | |
| Q8BS14 | |
| Q8CI98 | |
| Q3TBW3 | |
| O35904 | |
| D4A5Q1 | |
| Q8CJ28 | |
| A6NCG0 | |
| G1FFP1 | |
| O15445 | |
| Q5SR49 | |
| O00334 | |
| Q59HC4 | |
| Q546P7 |
| PIR ID | T43502 |
|---|
| Unigene ID | Hs.518451 |
|---|---|
| Mm.229108 | |
| Rn.11530 |
| KEGG ID | hsa:5293 |
|---|---|
| mmu:18707 | |
| rno:366508 |
| Swiss-Prot ID | PK3CD_MOUSE |
|---|---|
| PK3CD_HUMAN |
| EC Number | 2.7.1.153 |
|---|
| Ensembl ID | ENSG00000171608 |
|---|---|
| ENSP00000366563 | |
| ENST00000377346 | |
| ENSP00000446444 | |
| ENST00000536656 | |
| ENSMUSG00000039936 | |
| ENSMUSP00000136045 | |
| ENSMUST00000177654 | |
| ENSMUSP00000101315 | |
| ENSMUST00000105690 | |
| ENSMUSP00000036434 | |
| ENSMUST00000038859 | |
| ENSMUSP00000112863 | |
| ENSMUST00000118704 | |
| ENSMUSP00000101313 | |
| ENSMUST00000105688 | |
| ENSRNOG00000016846 | |
| ENSRNOP00000061674 | |
| ENSRNOT00000066179 |
| Homologene ID | 3686 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1098211 |
|---|
| RGD ID | 1310990 |
|---|
| MedScan ID | 5293 |
|---|