| URN | urn:agi-llid:5291 |
|---|---|
| Total Entities | 0 |
| Connectivity | 374 |
| Name | Pik3cb |
| Description | hypothetical protein LOC100001865 |
| Notes | A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. Data highlight the differential signaling by p110alpha and -beta isoforms. Introduction of a pH1 vector producing shRNA (short hairpin RNA) that targets p110beta abolished PIA [N6-(2-phenylisopropyl)adenosine]-induced Akt activation. It is unlikely that the promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human PI 3-kinase have a major impact on insulin secretion, insulin sensitivity, or the risk of type 2 diabetes. Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]. These results indicate that in addition to their roles in recruiting the catalytic subunit of PI3K to the insulin receptor substrate proteins, both p85alpha and p85beta play negative roles in insulin signaling. This paper reports the first purification of a phosphoinositide 3-kinase and shows that the protein is a heterodimer of an 85 kd regulatory subunit that mediates binding to phosphorylated proteins and a 110 kd catalytic subunit. Although introduction of activating mutations from p110alpha at the corresponding sites in p110beta failed to render the enzyme oncogenic in human cells, the possibility remains that other mutations might activate the beta isoform. Determinination of the involvement of PI3K and MAPK pathways and the importance of cross-talk between these pathways, in glucose-potentiated vascular smooth muscle cell chemotaxis to serum factors. P110 has a role in activation of PI3K gamma along with G beta gamma. P110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase have roles in oncogenic transformation. |
| GO Molecular Function | 1-phosphatidylinositol-3-kinase activity |
|---|---|
| phosphatidylinositol 3-kinase activity | |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| insulin receptor substrate binding | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | brush border membrane |
|---|---|
| phosphatidylinositol 3-kinase complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | leukocyte migration |
|---|---|
| Fc-gamma receptor signaling pathway involved in phagocytosis | |
| T cell receptor signaling pathway | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phosphatidylinositol-3-phosphate biosynthetic process | |
| activation of MAPK activity | |
| phospholipid metabolic process | |
| phosphatidylinositol phosphorylation | |
| blood coagulation | |
| platelet activation | |
| platelet aggregation | |
| embryonic cleavage | |
| cell adhesion | |
| signal transduction | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| G-protein coupled receptor signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| homophilic cell adhesion | |
| regulation of cell-matrix adhesion | |
| cellular calcium ion homeostasis | |
| cell migration | |
| chemotaxis | |
| positive regulation of autophagy | |
| regulation of clathrin-mediated endocytosis | |
| phosphorylation | |
| autophagy | |
| endocytosis |
| Pathway | Proteins Involved in Pathogenesis of Prostate Cancer |
|---|---|
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | PI3K |
|---|---|
| leukocyte migration | |
| Fc-gamma receptor signaling pathway involved in phagocytosis | |
| T cell receptor signaling pathway | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phosphatidylinositol-3-phosphate biosynthetic process | |
| 1-phosphatidylinositol-3-kinase activity | |
| activation of MAPK activity | |
| phospholipid metabolic process | |
| phosphatidylinositol phosphorylation | |
| phosphatidylinositol 3-kinase activity | |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| blood coagulation | |
| platelet activation | |
| platelet aggregation | |
| embryonic cleavage | |
| cell adhesion | |
| signal transduction | |
| phosphatidylinositol-mediated signaling | |
| phosphatidylinositol 3-kinase signaling | |
| G-protein coupled receptor signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| homophilic cell adhesion | |
| regulation of cell-matrix adhesion | |
| cellular calcium ion homeostasis | |
| cell migration | |
| chemotaxis | |
| positive regulation of autophagy | |
| regulation of clathrin-mediated endocytosis | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| phosphorylation | |
| autophagy | |
| endocytosis | |
| insulin receptor substrate binding | |
| nucleotide binding | |
| ATP binding | |
| brush border membrane | |
| phosphatidylinositol 3-kinase complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| Source | GO component |
|---|
| LocusLink ID | 5291 |
|---|---|
| 74769 | |
| 85243 | |
| 102512 | |
| 517948 | |
| 100001865 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0016303 |
|---|---|
| 0035005 | |
| 0005524 | |
| 0043560 | |
| 0035004 | |
| 0046934 | |
| 0038095 | |
| 0038096 | |
| 0007186 | |
| 0050852 | |
| 0000187 | |
| 0006914 | |
| 0007596 | |
| 0016477 | |
| 0006874 | |
| 0006935 | |
| 0040016 | |
| 0007173 | |
| 0008543 | |
| 0007156 | |
| 0045087 | |
| 0008286 | |
| 0050900 | |
| 0048011 | |
| 0014065 | |
| 0006661 | |
| 0048015 | |
| 0006644 | |
| 0030168 | |
| 0070527 | |
| 0010508 | |
| 0001952 | |
| 2000369 | |
| 0007165 | |
| 0044281 | |
| 0007169 | |
| 0005829 | |
| 0005634 | |
| 0005942 | |
| 0005886 | |
| 0016301 | |
| 0000166 | |
| 0016773 | |
| 0016740 | |
| 0016772 | |
| 0007155 | |
| 0006897 | |
| 0046854 | |
| 0036092 | |
| 0016310 | |
| 0031526 | |
| 0005737 | |
| 0005488 | |
| 0004428 | |
| 0005575 | |
| 0000074 | |
| 0008372 | |
| 0005554 |
| Alias | PI3K |
|---|---|
| PIK3C1 | |
| P110BETA | |
| PI3KBETA | |
| phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | |
| PI3K-beta | |
| PtdIns-3-kinase p110 | |
| PI3-kinase subunit beta | |
| PI3-kinase p110 subunit beta | |
| ptdIns-3-kinase subunit beta | |
| ptdIns-3-kinase subunit p110-beta | |
| phosphoinositide-3-kinase, catalytic, beta polypeptide | |
| phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta | |
| AI447572 | |
| 1110001J02Rik | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform | |
| catalytic phosphatidylinositol 3-kinase beta | |
| phosphatidylinositol 3-kinase, catalytic, beta polypeptide | |
| phosphatidylinositol 3-kinase catalytic subunit beta isoform | |
| phosphatidylinositol 3-kinase, catalytic subunit, beta isoform | |
| PI3KCB | |
| PIK3C I | |
| PIK3CB | |
| 1110001J02 | |
| DKFZp779K1237 | |
| MGC133043 | |
| OTTHUMP00000216901 | |
| OTTHUMP00000216904 | |
| OTTMUSP00000023176 | |
| MGC150132 | |
| p110-BETA | |
| Phosphatidylinositol 3-kinase catalytic subunit, beta isoform | |
| LOC100001865 | |
| chromosome | |
| hypothetical protein LOC100001865 | |
| scaffold |
| Mouse chromosome position | 9 |
|---|---|
| 9 E4 |
| OMIM ID | 602925 |
|---|
| Rat chromosome position | 8q31 |
|---|
| Hugo ID | 8976 |
|---|
| Human chromosome position | 3q22.3 |
|---|
| Swiss-Prot Accession | B4DER4 |
|---|---|
| P42338 | |
| Q8BTI9 | |
| Q9Z1L0 | |
| D3DNF0 | |
| Q24JU2 | |
| Q3U4Q1 | |
| Q68DL0 | |
| Q6PJ60 | |
| Q9BTS4 |
| PIR ID | A54600 |
|---|
| Unigene ID | Hs.239818 |
|---|---|
| Mm.213128 | |
| Rn.44268 | |
| Bt.77759 |
| KEGG ID | hsa:5291 |
|---|---|
| mmu:74769 | |
| rno:85243 |
| Swiss-Prot ID | PK3CB_HUMAN |
|---|---|
| PK3CB_RAT | |
| PK3CB_MOUSE |
| EC Number | 2.7.1.153 |
|---|---|
| 2.7.1.137 |
| Ensembl ID | ENSMUSG00000032462 |
|---|---|
| ENSMUSP00000035037 | |
| ENSMUST00000035037 | |
| ENSRNOG00000016384 | |
| ENSRNOP00000022179 | |
| ENSRNOT00000022179 |
| Homologene ID | 21250 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| MGI ID | 1922019 |
|---|---|
| 2143049 |
| RGD ID | 620917 |
|---|
| MedScan ID | 5291 |
|---|
| KEGG pathway | Apoptosis |
|---|---|
| B cell receptor signaling pathway | |
| Focal adhesion | |
| Inositol phosphate metabolism | |
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| Phosphatidylinositol signaling system | |
| Regulation of actin cytoskeleton | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Type II diabetes mellitus | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Fc epsilon RI signaling pathway | |
| Glioma | |
| Leukocyte transendothelial migration | |
| Melanoma | |
| Natural killer cell mediated cytotoxicity | |
| Pancreatic cancer | |
| VEGF signaling pathway | |
| mTOR signaling pathway | |
| Endometrial cancer | |
| ErbB signaling pathway | |
| Non-small cell lung cancer | |
| Prostate cancer | |
| Renal cell carcinoma | |
| Small cell lung cancer |
| Homo sapiens Chromosome position | 3q22.3 |
|---|
| Microarray ID | 212688_at |
|---|---|
| 1453069_at |
| FunctionalClass | inositol or phosphatidylinositol kinase |
|---|---|
| phosphatidylinositol 3-kinase | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase | |
| transferase | |
| kinase | |
| molecular function unknown | |
| phosphotransferase activity, alcohol group as acceptor | |
| phosphoinositide 3-kinase | |
| insulin receptor substrate binding | |
| 1-phosphatidylinositol-3-kinase |
| Bos taurus Chromosome position | 1 |
|---|
| Mus musculus Chromosome position | 9 E4 |
|---|---|
| 9 |
| Rattus norvegicus Chromosome position | 8q31 |
|---|