| URN | urn:agi-llid:5291 |
|---|---|
| Connectivity | 104 |
| Name | Pik3cb |
| Description | hypothetical protein LOC100001865 |
| Notes | A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. Data highlight the differential signaling by p110alpha and -beta isoforms. Introduction of a pH1 vector producing shRNA (short hairpin RNA) that targets p110beta abolished PIA [N6-(2-phenylisopropyl)adenosine]-induced Akt activation. It is unlikely that the promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human PI 3-kinase have a major impact on insulin secretion, insulin sensitivity, or the risk of type 2 diabetes. Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]. These results indicate that in addition to their roles in recruiting the catalytic subunit of PI3K to the insulin receptor substrate proteins, both p85alpha and p85beta play negative roles in insulin signaling. This paper reports the first purification of a phosphoinositide 3-kinase and shows that the protein is a heterodimer of an 85 kd regulatory subunit that mediates binding to phosphorylated proteins and a 110 kd catalytic subunit. Although introduction of activating mutations from p110alpha at the corresponding sites in p110beta failed to render the enzyme oncogenic in human cells, the possibility remains that other mutations might activate the beta isoform. Determinination of the involvement of PI3K and MAPK pathways and the importance of cross-talk between these pathways, in glucose-potentiated vascular smooth muscle cell chemotaxis to serum factors. P110 has a role in activation of PI3K gamma along with G beta gamma. P110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase have roles in oncogenic transformation. |
| Pathway | phosphatidylinositol 3-kinase-Akt signaling pathway |
|---|---|
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| insulin receptor substrate binding | |
| ATP binding | |
| phosphotransferase activity, alcohol group as acceptor | |
| kinase activity | |
| phosphoinositide 3-kinase activity | |
| inositol or phosphatidylinositol kinase activity | |
| 1-phosphatidylinositol-3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| GO Cellular Component | cytosol |
|---|---|
| phosphoinositide 3-kinase complex | |
| brush border membrane |
| GO Biological Process | platelet activation |
|---|---|
| signal transduction | |
| embryonic cleavage | |
| activation of MAPK activity | |
| phosphoinositide-mediated signaling | |
| regulation of cell-matrix adhesion | |
| homophilic cell adhesion | |
| phosphoinositide phosphorylation | |
| cellular calcium ion homeostasis | |
| chemotaxis | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | PI3K |
|---|
| Group | PI3K |
|---|---|
| platelet activation | |
| signal transduction | |
| embryonic cleavage | |
| activation of MAPK activity | |
| phosphoinositide-mediated signaling | |
| regulation of cell-matrix adhesion | |
| homophilic cell adhesion | |
| phosphoinositide phosphorylation | |
| cellular calcium ion homeostasis | |
| chemotaxis | |
| G-protein coupled receptor protein signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| insulin receptor substrate binding | |
| ATP binding | |
| phosphotransferase activity, alcohol group as acceptor | |
| kinase activity | |
| phosphoinositide 3-kinase activity | |
| inositol or phosphatidylinositol kinase activity | |
| 1-phosphatidylinositol-3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| cytosol | |
| phosphoinositide 3-kinase complex | |
| brush border membrane |
| MedScan ID | 5291 |
|---|
| Hugo ID | 8976 |
|---|
| Human chromosome position | 3q22.3 |
|---|
| LocusLink ID | 5291 |
|---|---|
| 74769 | |
| 85243 | |
| 102512 | |
| 517948 | |
| 100001865 |
| Alias | PI3K |
|---|---|
| PIK3C1 | |
| P110BETA | |
| PI3KBETA | |
| MGC133043 | |
| DKFZp779K1237 | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform | |
| PI3K-beta | |
| OTTHUMP00000216901 | |
| OTTHUMP00000216904 | |
| PtdIns-3-kinase p110 | |
| PI3-kinase subunit beta | |
| PI3-kinase p110 subunit beta | |
| ptdIns-3-kinase subunit beta | |
| ptdIns-3-kinase subunit p110-beta | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta | |
| AI447572 | |
| MGC150132 | |
| 1110001J02Rik | |
| OTTMUSP00000023176 | |
| catalytic phosphatidylinositol 3-kinase beta | |
| phosphatidylinositol 3-kinase, catalytic, beta polypeptide | |
| phosphatidylinositol 3-kinase catalytic subunit beta isoform | |
| phosphatidylinositol 3-kinase, catalytic subunit, beta isoform | |
| 1110001J02 | |
| phosphoinositide-3-kinase, catalytic, beta polypeptide | |
| PI3KCB | |
| PIK3C I | |
| PIK3CB | |
| p110-BETA | |
| Phosphatidylinositol 3-kinase catalytic subunit, beta isoform | |
| LOC100001865 | |
| chromosome | |
| hypothetical protein LOC100001865 | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 602925 |
|---|
| Mouse chromosome position | 9 |
|---|---|
| 9 E4 |
| GO ID | 0016303 |
|---|---|
| 0005524 | |
| 0004428 | |
| 0043560 | |
| 0000166 | |
| 0046934 | |
| 0016773 | |
| 0016740 | |
| 0007186 | |
| 0000187 | |
| 0006874 | |
| 0006935 | |
| 0040016 | |
| 0007156 | |
| 0046854 | |
| 0048015 | |
| 0030168 | |
| 0001952 | |
| 0007165 | |
| 0005829 | |
| 0005942 | |
| 0016301 | |
| 0031526 | |
| 0035004 | |
| 0005488 | |
| 0005575 | |
| 0000074 | |
| 0008372 | |
| 0005554 |
| Rat chromosome position | 8q31 |
|---|
| Swiss-Prot Accession | P42338 |
|---|---|
| Q68DL0 | |
| Q6PJ60 | |
| Q9BTS4 | |
| Q3U4Q1 | |
| Q3TNJ8 | |
| Q8BTI9 | |
| Q8CFF1 | |
| Q9CTK7 | |
| Q9Z1L0 | |
| Q24JU2 | |
| D3DNF0 |
| PIR ID | A54600 |
|---|
| Unigene ID | Hs.239818 |
|---|---|
| Mm.213128 | |
| Rn.44268 | |
| Bt.77759 |
| KEGG ID | hsa:5291 |
|---|---|
| mmu:74769 | |
| rno:85243 |
| EC Number | 2.7.1.153 |
|---|---|
| 2.7.1.137 |
| Swiss-Prot ID | PK3CB_RAT |
|---|---|
| PK3CB_HUMAN | |
| Q3U4Q1_MOUSE | |
| D3DNF0_HUMAN | |
| PK3CB_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00208989 |
|---|---|
| IPI00031388 | |
| IPI00954674 | |
| IPI00797179 | |
| IPI00136110 | |
| IPI00831149 |
| Homologene ID | 21250 |
|---|
| RGD ID | 620917 |
|---|
| MGI ID | 1922019 |
|---|---|
| 2143049 |
| Microarray ID | 212688_at |
|---|---|
| 1453069_at |
| FunctionalClass | inositol or phosphatidylinositol kinase |
|---|---|
| phosphatidylinositol 3-kinase | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase | |
| transferase | |
| kinase | |
| molecular function unknown | |
| phosphotransferase activity, alcohol group as acceptor | |
| phosphoinositide 3-kinase | |
| insulin receptor substrate binding | |
| 1-phosphatidylinositol-3-kinase |
| Mus musculus Chromosome position | 9 E4 |
|---|---|
| 9 |
| Source | GO component |
|---|
| KEGG pathway | Apoptosis |
|---|---|
| B cell receptor signaling pathway | |
| Focal adhesion | |
| Inositol phosphate metabolism | |
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| Phosphatidylinositol signaling system | |
| Regulation of actin cytoskeleton | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Type II diabetes mellitus | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Fc epsilon RI signaling pathway | |
| Glioma | |
| Leukocyte transendothelial migration | |
| Melanoma | |
| Natural killer cell mediated cytotoxicity | |
| Pancreatic cancer | |
| VEGF signaling pathway | |
| mTOR signaling pathway | |
| Endometrial cancer | |
| ErbB signaling pathway | |
| Non-small cell lung cancer | |
| Prostate cancer | |
| Renal cell carcinoma | |
| Small cell lung cancer |
| Homo sapiens Chromosome position | 3q22.3 |
|---|
| Bos taurus Chromosome position | 1 |
|---|
| Rattus norvegicus Chromosome position | 8q31 |
|---|