| URN | urn:agi-llid:5170 |
|---|---|
| Connectivity | 372 |
| Name | Pdpk1 |
| Description | 3-phosphoinositide dependent protein kinase-1 |
| Notes | may catalyze the phosphorylation and activation of protein kinase B [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| PDGFR -> FOXO3A signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| VEGFR -> FOXO3A signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> FOXO3A signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ErythropoietinR -> FOXO3A signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| NTRK -> FOXO/MYCN signaling | |
| AngiopoietinR -> FOXO signaling | |
| GDNF -> HSF1 signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| IGF1R -> CEBPA/FOXO1A signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> CTNNB signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| GHR -> NF-kB signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| ErythropoietinR -> NF-kB signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| ERBB2/3 -> EP300/ETS/ETV/SP1 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| KIT -> MITF signaling | |
| VEGFR -> CTNNB signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL15R -> NF-kB/NFATC signaling | |
| IL2R -> ELK-SRF/MYC signaling | |
| IL4R -> ELK-SRF/HMGY signaling | |
| IL7R -> FOXO/NF-kB signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| CD19 -> NF-kB signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| ThrombinR -> NF-kB signaling | |
| CannabinoidR -> AP-1/EGR signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| DopamineR2 -> NF-kB signaling | |
| EDG2 -> ELK-SRF signaling | |
| NeuropeptideYR -> ATF/CREB signaling | |
| SerotoninR1 -> FOS signaling | |
| AdenosineR -> NF-kB signaling | |
| NeurotensinR -> ELK-SRF/AP-1/EGR signaling | |
| PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling | |
| PTAFR -> NF-kB signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| AdrenergicRb -> STAT3 signaling | |
| FSHR -> FOXO1A signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| FcIgER -> ELK-SRF signaling | |
| Notch -> NF-kB signaling | |
| AGER -> NF-kB signaling | |
| UrokinaseR -> ELK-SRF signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| CD38 -> NF-kB signaling | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| protein kinase C (PKC) signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| insulin receptor binding | |
| protein kinase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| 3-phosphoinositide-dependent protein kinase activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle |
| GO Biological Process | signal transduction |
|---|---|
| positive regulation of establishment of protein localization in plasma membrane | |
| actin cytoskeleton organization | |
| negative regulation of protein kinase activity | |
| activation of protein kinase B activity | |
| protein amino acid phosphorylation | |
| peptidyl-threonine phosphorylation | |
| cellular response to insulin stimulus | |
| focal adhesion assembly | |
| hyperosmotic response | |
| intracellular signaling pathway |
| Ariadne Ontology | PDPK1 |
|---|
| Group | PDPK1 |
|---|---|
| signal transduction | |
| positive regulation of establishment of protein localization in plasma membrane | |
| actin cytoskeleton organization | |
| negative regulation of protein kinase activity | |
| activation of protein kinase B activity | |
| protein amino acid phosphorylation | |
| peptidyl-threonine phosphorylation | |
| cellular response to insulin stimulus | |
| focal adhesion assembly | |
| hyperosmotic response | |
| intracellular signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| insulin receptor binding | |
| protein kinase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| 3-phosphoinositide-dependent protein kinase activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle |
| MedScan ID | 5170 |
|---|
| Hugo ID | 8816 |
|---|
| Human chromosome position | 16p13.3 |
|---|
| LocusLink ID | 5170 |
|---|---|
| 18607 | |
| 81745 | |
| 28993 | |
| 792239 |
| Alias | PDK1 |
|---|---|
| PRO0461 | |
| MGC20087 | |
| MGC35290 | |
| 3-phosphoinositide-dependent protein kinase 1 | |
| hPDK1 | |
| PkB-like 1 | |
| protein kinase | |
| OTTHUMP00000174525 | |
| PkB kinase like gene 1 | |
| RP23-153H18.1 | |
| mPDK1 | |
| Pkb kinase | |
| OTTMUSP00000017452 | |
| OTTMUSP00000022124 | |
| OTTMUSP00000022125 | |
| protein kinase B kinase | |
| 3-phosphoinositide dependent protein kinase I | |
| 3-phosphoinositide dependent protein kinase-1 | |
| hPDK I | |
| Pdk I | |
| PDPK I | |
| PDPK1 | |
| Phosphoinositide-dependent kinase 1 | |
| PkB kinase like gene I | |
| PkB-like | |
| PkB-like I | |
| PDK-1 | |
| PIP3 | |
| LOC792239 | |
| chromosome | |
| hypothetical protein LOC792239 | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Danio rerio | |
| Human |
| OMIM ID | 605213 |
|---|---|
| OMIM:605213 |
| Mouse chromosome position | 17 |
|---|---|
| 17 A3.3 |
| GO ID | 0004676 |
|---|---|
| 0005524 | |
| 0005158 | |
| 0000166 | |
| 0019901 | |
| 0004674 | |
| 0016740 | |
| 0030036 | |
| 0032148 | |
| 0032869 | |
| 0048041 | |
| 0006972 | |
| 0023034 | |
| 0006469 | |
| 0018107 | |
| 0090004 | |
| 0005737 | |
| 0016023 | |
| 0005829 | |
| 0005886 | |
| 0016301 | |
| 0004672 | |
| 0006468 | |
| 0007165 | |
| 0016020 | |
| 0007242 | |
| 0005515 | |
| 0008286 | |
| 0070201 | |
| 0004197 | |
| 0006508 | |
| 0004713 | |
| 0000287 | |
| 0030295 | |
| 0004682 | |
| 0004691 |
| Rat chromosome position | 10q12 |
|---|
| Swiss-Prot Accession | O15530 |
|---|---|
| Q9BRD5 | |
| Q53HJ9 | |
| Q59EH6 | |
| Q9UPJ7 | |
| Q9UPJ8 | |
| Q3TRL2 | |
| Q3UGN6 | |
| Q3UHZ0 | |
| Q9Z2A0 | |
| Q3UEW8 | |
| Q810Z4 | |
| Q8K3L3 | |
| O55173 | |
| Q6FI20 | |
| A6H6U3 | |
| Q9R1D8 | |
| Q9R215 | |
| Q8IV52 | |
| Q9UI25 |
| Unigene ID | Hs.459691 |
|---|---|
| Mm.10504 | |
| Rn.10905 | |
| Dr.29812 | |
| Hs.154729 |
| KEGG ID | hsa:5170 |
|---|---|
| mmu:18607 | |
| rno:81745 |
| EC Number | 2.7.11.1 |
|---|---|
| 2.7.1.37 |
| Swiss-Prot ID | PDPK1_RAT |
|---|---|
| PDPK1_HUMAN | |
| PDPK1_MOUSE | |
| Q9BRD5_HUMAN | |
| Q3UGN6_MOUSE | |
| Q3TRL2_MOUSE | |
| Q3UHZ0_MOUSE | |
| A6H6U3_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Membrane | |
| Plasma membrane |
| IPI ID | IPI00195987 |
|---|---|
| IPI00002538 | |
| IPI00216646 | |
| IPI00216647 | |
| IPI00323609 | |
| IPI00216877 | |
| IPI00828763 | |
| IPI00005991 | |
| IPI00867720 | |
| IPI00478389 | |
| IPI00831145 | |
| IPI00831240 | |
| IPI00831328 | |
| IPI00831411 | |
| IPI00830337 | |
| IPI00831634 |
| Homologene ID | 37643 |
|---|
| RGD ID | 620307 |
|---|
| MGI ID | 1338068 |
|---|
| Microarray ID | 102063_at |
|---|---|
| 160578_at | |
| 1416501_at | |
| 1370052_at | |
| y15748_at | |
| A_43_P12504 | |
| 134947_r_at | |
| msa.34345.0_s_at | |
| A_51_P207140 | |
| A_52_P619138 | |
| Y15056 | |
| 222260_at | |
| 32029_at | |
| 73168_s_at | |
| 204524_at | |
| 224986_s_at | |
| 232050_at | |
| RC_AA041276_at | |
| rc_aa019394_at | |
| 221244_s_at | |
| 64052_at | |
| rc_aa488978_at | |
| A_14_P128757 | |
| A_23_P66219 | |
| A_14_P107472 | |
| A_14_P120883 | |
| A_24_P830690 | |
| A_14_P123854 | |
| A_24_P222599 | |
| A_32_P344843 | |
| A_23_P10614 | |
| A_24_P37441 |
| FunctionalClass | 3-phosphoinositide-dependent protein kinase |
|---|---|
| ATP binding | |
| nucleotide binding | |
| protein serine/threonine kinase | |
| transferase | |
| kinase | |
| protein kinase | |
| insulin receptor binding | |
| protein kinase activator | |
| protein kinase binding | |
| protein-tyrosine kinase | |
| cAMP-dependent protein kinase | |
| magnesium ion binding | |
| protein kinase CK2 | |
| protein binding |
| Mus musculus Chromosome position | 17 A3.3 |
|---|
| Source | Curated |
|---|---|
| GO component | |
| ResNet |
| KEGG pathway | Insulin signaling pathway |
|---|---|
| Focal adhesion | |
| PPAR signaling pathway | |
| mTOR signaling pathway | |
| Endometrial cancer | |
| Non-small cell lung cancer | |
| Prostate cancer |
| Homo sapiens Chromosome position | 16p13.3 |
|---|
| Rattus norvegicus Chromosome position | 10q12 |
|---|